Protein: SH2B2
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)

Gene: SH2B2
Organism: Homo sapiens
Interactions: 40
UniProt ID: O14492

Gene Ontology (top 5):
GO:0001725 - stress fiber
GO:0001726 - ruffle
GO:0001922 - B-1 B cell homeostasis
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

145965

NTRK1
High affinity nerve growth factor receptor

2

20

Small-scale

0.800

High

145968

HCK
Tyrosine-protein kinase HCK

2

19

High-throughput

0.783

High

145992

PKHA3
Pleckstrin homology domain-containing family A member 3

2

16

High-throughput

0.783

High

145994

RAB6B
Ras-related protein Rab-6B

2

15

High-throughput

0.783

High

145995

ASB6
Ankyrin repeat and SOCS box protein 6

2

15

High-throughput

0.783

High

145964

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

145987

WDR83
WD repeat domain-containing protein 83

3

1

High-throughput

0.770

High

145977

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.768

High

145966

INSR
Insulin receptor

2

20

Small-scale

0.757

High

145961

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.755

High

145988

SRBS1
Sorbin and SH3 domain-containing protein 1

2

20

Small-scale

0.754

High

145985

MCRS1
Microspherule protein 1

2

0

High-throughput

0.742

High

145972

CBL
E3 ubiquitin-protein ligase CBL

5

20

Small-scale

0.723

High

145993

SH2B1
SH2B adapter protein 1

1

19

Small-scale

0.713

High

145975

CLK1
Dual specificity protein kinase CLK1

2

14

High-throughput

0.700

High

145976

CLK3
Dual specificity protein kinase CLK3

2

14

High-throughput

0.700

High

145967

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

145969

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.691

High

145963

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.647

High

145971

EPOR
Erythropoietin receptor

1

20

Small-scale

0.647

High

145973

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.647

High

145979

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

145959

SH2B2
SH2B adapter protein 2

1

18

Small-scale

0.621

High

145960

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

Small-scale

0.618

High

145974

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.618

High

145962

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

16

High-throughput

0.606

High

145982

LMO3
LIM domain only protein 3

2

20

High-throughput

0.606

High

145989

TLRN1
Talin rod domain-containing protein 1

2

1

High-throughput

0.606

High

145996

I36RA
Interleukin-36 receptor antagonist protein

2

3

High-throughput

0.606

High

145997

DS13B
Dual specificity protein phosphatase 13B

2

10

High-throughput

0.606

High

145978

TLE5
TLE family member 5

2

3

High-throughput

0.553

High

145981

F90A1
Protein FAM90A1

2

1

High-throughput

0.553

High

145983

ZN417
Zinc finger protein 417

2

7

High-throughput

0.553

High

145990

MAGH1
Melanoma-associated antigen H1

2

4

High-throughput

0.553

High

145991

F124B
Protein FAM124B

2

1

High-throughput

0.553

High

145970

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

15

High-throughput

0.536

High

145980

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

145984

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.437

High

145986

ZN414
Zinc finger protein 414

2

0

High-throughput

0.316

High


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Last updated: 15 Jul 2024