Protein: CASP1
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]

Gene: CASP1
Organism: Homo sapiens
Interactions: 100
UniProt ID: P29466

Gene Ontology (top 5):
GO:0002221 - pattern recognition receptor signaling pathway
GO:0004175 - endopeptidase activity
GO:0004197 - cysteine-type endopeptidase activity
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667498

ASC
Apoptosis-associated speck-like protein containing a CARD

13

16

Small-scale

0.978

High

667491

NLRC4
NLR family CARD domain-containing protein 4

6

20

Small-scale

0.938

High

201759

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

6

8

Small-scale

0.935

High

667430

CASP1
Caspase-1

5

17

Small-scale

0.910

High

667487

NLRP1
NACHT, LRR and PYD domains-containing protein 1

4

20

Small-scale

0.881

High

667502

CARD8
Caspase recruitment domain-containing protein 8

3

10

Small-scale

0.821

High

667490

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

20

Small-scale

0.789

High

667472

CAR16
Caspase recruitment domain-containing protein 16

2

17

Small-scale

0.789

High

667446

GSDMD
Gasdermin-D

1

3

Small-scale

0.777

High

667473

CAR17
Putative caspase recruitment domain-containing protein 17P

1

11

Small-scale

0.733

High

352989

IL1B
Interleukin-1 beta

6

7

Small-scale

0.732

High

667465

IL18
Interleukin-18

5

3

Small-scale

0.718

High

667452

VAC14
Protein VAC14 homolog

4

2

High-throughput

0.705

High

667445

CAR18
Caspase recruitment domain-containing protein 18

1

11

Small-scale

0.701

High

183325

MEFV
Pyrin

4

3

Small-scale

0.694

High

667484

NLRP3
NACHT, LRR and PYD domains-containing protein 3

4

20

Small-scale

0.676

High

667443

KIF11
Kinesin-like protein KIF11

3

1

High-throughput

0.667

High

667496

PI4KB
Phosphatidylinositol 4-kinase beta

3

1

High-throughput

0.667

High

667503

KIF3A
Kinesin-like protein KIF3A

3

1

High-throughput

0.667

High

226605

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.665

High

667433

CASP3
Caspase-3

1

17

Small-scale

0.647

High

667467

CASP8
Caspase-8

1

17

Small-scale

0.647

High

667482

CASPA
Caspase-10

1

17

Small-scale

0.647

High

667460

GAB1
GRB2-associated-binding protein 1

3

0

High-throughput

0.638

High

667471

ARI4B
AT-rich interactive domain-containing protein 4B

3

0

High-throughput

0.638

High

667494

FMN2
Formin-2

3

0

High-throughput

0.638

High

667431

CASPE
Caspase-14

1

17

Small-scale

0.618

High

667451

B2CL1
Bcl-2-like protein 1

1

8

Small-scale

0.618

High

667461

BIRC3
Baculoviral IAP repeat-containing protein 3

1

20

Small-scale

0.618

High

667501

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

20

Small-scale

0.618

High

321311

IL33
Interleukin-33

2

2

Small-scale

0.617

High

667500

PLCL2
Inactive phospholipase C-like protein 2

2

0

High-throughput

0.602

High

667447

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

0

Small-scale

0.599

High

569243

CEBPB
CCAAT/enhancer-binding protein beta

2

3

Small-scale

0.584

High

667469

IF16
Gamma-interferon-inducible protein 16

2

1

Small-scale

0.584

High

667457

PAK1
Serine/threonine-protein kinase PAK 1

1

6

Small-scale

0.578

High

337990

EGFR
Epidermal growth factor receptor

1

6

Small-scale

0.569

High

667495

IL37
Interleukin-37

1

6

Small-scale

0.569

High

667483

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

Small-scale

0.561

High

528608

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

667480

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

20

Small-scale

0.515

High

241148

TOM1
Target of Myb1 membrane trafficking protein

1

1

High-throughput

0.515

High

394174

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.515

High

535332

GFAP
Glial fibrillary acidic protein

1

5

High-throughput

0.515

High

655226

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.515

High

667434

HD
Huntingtin

1

4

High-throughput

0.515

High

667444

ATX3
Ataxin-3

1

2

High-throughput

0.515

High

667450

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.515

High

667464

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.515

High

667453

DMWD
Dystrophia myotonica WD repeat-containing protein

1

0

High-throughput

0.513

High

455123

PARP1
Poly [ADP-ribose] polymerase 1

1

9

Small-scale

0.501

High

473772

PA24B
Cytosolic phospholipase A2 beta

1

7

Small-scale

0.501

High

486151

GRAB
Granzyme B

1

11

Small-scale

0.501

High

496377

TAU
Microtubule-associated protein tau

1

7

Small-scale

0.501

High

667436

PA24A
Cytosolic phospholipase A2

1

7

Small-scale

0.501

High

667439

SPB9
Serpin B9

1

8

Small-scale

0.501

High

667440

BAP31
B-cell receptor-associated protein 31

1

1

Small-scale

0.501

High

667442

GDIR1
Rho GDP-dissociation inhibitor 1

1

8

Small-scale

0.501

High

667474

A16L1
Autophagy-related protein 16-1

1

3

Small-scale

0.501

High

667476

MAVS
Mitochondrial antiviral-signaling protein

1

4

Small-scale

0.501

High

667477

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

Small-scale

0.501

High

157009

AIM2
Interferon-inducible protein AIM2

1

1

Small-scale

0.494

High

352962

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.493

High

146075

PLPP1
Phospholipid phosphatase 1

1

0

High-throughput

0.493

High

667438

PSN2
Presenilin-2

1

0

High-throughput

0.493

High

667459

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

0

High-throughput

0.493

High

667485

TM2D1
TM2 domain-containing protein 1

1

0

High-throughput

0.493

High

667497

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.493

High

243984

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

408742

K1C18
Keratin, type I cytoskeletal 18

1

1

Small-scale

0.479

High

447026

FGF2
Fibroblast growth factor 2

1

1

Small-scale

0.479

High

575285

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

667432

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.479

High

667437

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

667441

XK
Endoplasmic reticulum membrane adapter protein XK

1

1

Small-scale

0.479

High

667448

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

20

Small-scale

0.479

High

667449

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

Small-scale

0.479

High

667454

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

667455

TRAF2
TNF receptor-associated factor 2

1

19

Small-scale

0.479

High

667458

TIF1B
Transcription intermediary factor 1-beta

1

6

Small-scale

0.479

High

667462

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

667463

CUL3
Cullin-3

1

5

Small-scale

0.479

High

667466

KEAP1
Kelch-like ECH-associated protein 1

1

3

Small-scale

0.479

High

667468

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

667470

TR16L
Tripartite motif-containing protein 16-like protein

1

4

Small-scale

0.479

High

667475

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

667478

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

20

Small-scale

0.479

High

667479

NEK7
Serine/threonine-protein kinase Nek7

1

5

Small-scale

0.479

High

667481

ESR2
Estrogen receptor beta

1

5

Small-scale

0.479

High

667486

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

5

Small-scale

0.479

High

667488

SHRPN
Sharpin

1

1

Small-scale

0.479

High

667489

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

2

Small-scale

0.479

High

667492

IFT57
Intraflagellar transport protein 57 homolog

1

2

Small-scale

0.479

High

667493

NALP2
NACHT, LRR and PYD domains-containing protein 2

1

20

Small-scale

0.479

High

667499

APC10
Anaphase-promoting complex subunit 10

1

2

Small-scale

0.479

High

409013

K2C8
Keratin, type II cytoskeletal 8

1

0

Small-scale

0.458

High

667456

FOXC1
Forkhead box protein C1

1

0

High-throughput

0.458

High

667435

KSYK
Tyrosine-protein kinase SYK

1

7

Small-scale

0.445

High

281557

WFS1
Wolframin

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024