Protein: DRD2
D(2) dopamine receptor (Dopamine D2 receptor)

Gene: DRD2
Organism: Homo sapiens
Interactions: 98
UniProt ID: P14416

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001591 - dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001659 - temperature homeostasis
GO:0001666 - response to hypoxia
GO:0001669 - acrosomal vesicle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

537251

DRD2
D(2) dopamine receptor

2

17

Small-scale

0.757

High

537259

SSR2
Somatostatin receptor type 2

1

18

Small-scale

0.747

High

537257

AA2AR
Adenosine receptor A2a

1

20

Small-scale

0.724

High

537262

OPRM
Mu-type opioid receptor

1

18

Small-scale

0.724

High

175995

GPR37
Prosaposin receptor GPR37

1

18

High-throughput

0.698

High

537261

GASR
Gastrin/cholecystokinin type B receptor

1

18

High-throughput

0.698

High

537298

LPAR1
Lysophosphatidic acid receptor 1

1

20

High-throughput

0.698

High

537274

NCS1
Neuronal calcium sensor 1

3

1

Small-scale

0.665

High

537330

HRH3
Histamine H3 receptor

1

17

Small-scale

0.647

High

537286

COL12
Collectin-12

2

1

High-throughput

0.628

High

154652

GNB5
Guanine nucleotide-binding protein subunit beta-5

1

7

Small-scale

0.621

High

408544

KPCB
Protein kinase C beta type

1

3

Small-scale

0.618

High

537254

DRD4
D(4) dopamine receptor

1

18

Small-scale

0.618

High

537260

ARRB2
Beta-arrestin-2

1

7

Small-scale

0.618

High

537306

NEB2
Neurabin-2

2

20

Small-scale

0.606

High

537324

MSRA
Mitochondrial peptide methionine sulfoxide reductase

2

0

High-throughput

0.602

High

537253

FLNA
Filamin-A

2

7

Small-scale

0.584

High

537270

TRPC1
Short transient receptor potential channel 1

1

4

Small-scale

0.573

High

537318

DISC1
Disrupted in schizophrenia 1 protein

1

1

Small-scale

0.561

High

146744

AGRB1
Adhesion G protein-coupled receptor B1

1

5

High-throughput

0.541

High

213189

SNG2
Synaptogyrin-2

1

3

High-throughput

0.541

High

277378

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

4

High-throughput

0.541

High

281528

WFS1
Wolframin

1

1

High-throughput

0.541

High

306975

RTN3
Reticulon-3

1

6

High-throughput

0.541

High

537255

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

3

High-throughput

0.541

High

537258

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

3

High-throughput

0.541

High

537263

ARL1
ADP-ribosylation factor-like protein 1

1

6

High-throughput

0.541

High

537264

TSN7
Tetraspanin-7

1

11

High-throughput

0.541

High

537269

B3A3
Anion exchange protein 3

1

1

High-throughput

0.541

High

537273

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.541

High

537282

SERC3
Serine incorporator 3

1

1

High-throughput

0.541

High

537284

RTN1
Reticulon-1

1

6

High-throughput

0.541

High

537287

WLS
Protein wntless homolog

1

5

High-throughput

0.541

High

537288

RHBD2
Rhomboid domain-containing protein 2

1

3

High-throughput

0.541

High

537295

CHPT1
Cholinephosphotransferase 1

1

1

High-throughput

0.541

High

537310

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.541

High

537311

YIPF3
Protein YIPF3

1

4

High-throughput

0.541

High

537312

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.541

High

537315

GDPD2
Glycerophosphoinositol inositolphosphodiesterase GDPD2

1

1

High-throughput

0.541

High

537317

RTN4
Reticulon-4

1

6

High-throughput

0.541

High

537321

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

4

High-throughput

0.541

High

537323

TEFF2
Tomoregulin-2

1

1

High-throughput

0.541

High

537329

VPP2
V-type proton ATPase 116 kDa subunit a 2

1

1

High-throughput

0.541

High

537331

AGRG1
Adhesion G-protein coupled receptor G1

1

2

High-throughput

0.541

High

307880

SNX4
Sorting nexin-4

1

3

High-throughput

0.536

High

537328

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

1

2

High-throughput

0.536

High

422338

NFM
Neurofilament medium polypeptide

1

2

Small-scale

0.527

High

537303

PAWR
PRKC apoptosis WT1 regulator protein

1

2

Small-scale

0.527

High

537314

E41L1
Band 4.1-like protein 1

1

4

Small-scale

0.527

High

537297

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

2

Small-scale

0.523

High

299141

CSCL1
CSC1-like protein 1

1

0

High-throughput

0.518

High

364518

TRFE
Serotransferrin

1

0

High-throughput

0.518

High

537252

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.518

High

537289

PLPR3
Phospholipid phosphatase-related protein type 3

1

0

High-throughput

0.518

High

537290

PAQR6
Membrane progestin receptor delta

1

0

High-throughput

0.518

High

537293

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.518

High

537296

S22AH
Solute carrier family 22 member 17

1

0

High-throughput

0.518

High

537299

APH1A
Gamma-secretase subunit APH-1A

1

0

High-throughput

0.518

High

537304

G137A
Integral membrane protein GPR137

1

0

High-throughput

0.518

High

537316

ZDHC4
Palmitoyltransferase ZDHHC4

1

0

High-throughput

0.518

High

537265

VDAC2
Voltage-dependent anion-selective channel protein 2

1

2

High-throughput

0.515

High

537278

SC6A3
Sodium-dependent dopamine transporter

1

3

Small-scale

0.515

High

537308

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

537292

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

2

Small-scale

0.512

High

537320

TRPC4
Short transient receptor potential channel 4

1

4

Small-scale

0.501

High

537325

TRPC5
Short transient receptor potential channel 5

1

4

Small-scale

0.501

High

237781

TSN3
Tetraspanin-3

1

11

High-throughput

0.494

High

537256

CERS1
Ceramide synthase 1

1

9

High-throughput

0.494

High

537271

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

1

High-throughput

0.494

High

537275

S35B1
Solute carrier family 35 member B1

1

2

High-throughput

0.494

High

537283

TRAM1
Translocating chain-associated membrane protein 1

1

9

High-throughput

0.494

High

537291

LFG1
Protein lifeguard 1

1

4

High-throughput

0.494

High

537300

CERS2
Ceramide synthase 2

1

9

High-throughput

0.494

High

537301

CREL1
Protein disulfide isomerase CRELD1

1

3

High-throughput

0.494

High

537307

SMIM7
Small integral membrane protein 7

1

1

High-throughput

0.494

High

537313

GHITM
Growth hormone-inducible transmembrane protein

1

4

High-throughput

0.494

High

537322

BAP29
B-cell receptor-associated protein 29

1

1

High-throughput

0.494

High

537327

PLLP
Plasmolipin

1

2

High-throughput

0.494

High

537309

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.489

High

537326

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

2

High-throughput

0.489

High

537305

CLIC6
Chloride intracellular channel protein 6

1

2

Small-scale

0.481

High

337862

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

537266

KCNJ6
G protein-activated inward rectifier potassium channel 2

1

8

Small-scale

0.479

High

537267

KCNJ5
G protein-activated inward rectifier potassium channel 4

1

8

Small-scale

0.479

High

537268

KCNJ3
G protein-activated inward rectifier potassium channel 1

1

8

Small-scale

0.479

High

537272

DYN2
Dynamin-2

1

3

Small-scale

0.479

High

537276

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.479

High

537277

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.479

High

537279

CAV1
Caveolin-1

1

6

Small-scale

0.479

High

537280

DYN1
Dynamin-1

1

3

Small-scale

0.479

High

537281

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.437

High

489560

OSTP
Osteopontin

1

0

High-throughput

0.282

High

537285

PIGG
GPI ethanolamine phosphate transferase 2

1

0

High-throughput

0.282

High

537294

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.282

High

537302

TM101
Transmembrane protein 101

1

0

High-throughput

0.282

High

537319

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.282

High

166879

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024