Protein: SP130
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)

Gene: SP130, SAP130
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9H0E3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0016607 - nuclear speck
GO:0030336 - negative regulation of cell migration
GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1038696

HDAC1
Histone deacetylase 1

7

8

Small-scale

0.748

High

1270429

HDAC2
Histone deacetylase 2

5

10

Small-scale

0.712

High

257829

SIN3B
Paired amphipathic helix protein Sin3b

3

6

High-throughput

0.667

High

983444

MAD1
Max dimerization protein 1

3

12

High-throughput

0.667

High

1083381

RBBP7
Histone-binding protein RBBP7

3

9

High-throughput

0.667

High

1327622

ING2
Inhibitor of growth protein 2

3

11

Small-scale

0.667

High

1327626

SHCAF
SIN3-HDAC complex-associated factor

3

2

Small-scale

0.667

High

265256

SAP30
Histone deacetylase complex subunit SAP30

3

3

High-throughput

0.656

High

818448

SOX2
Transcription factor SOX-2

3

19

Small-scale

0.656

High

898191

MAX
Protein max

2

11

High-throughput

0.628

High

964251

FOXK2
Forkhead box protein K2

2

10

Small-scale

0.628

High

1169249

ZN704
Zinc finger protein 704

2

0

High-throughput

0.602

High

1312990

PHF23
PHD finger protein 23

2

0

High-throughput

0.602

High

347854

MYC
Myc proto-oncogene protein

2

13

Small-scale

0.595

High

244918

BRD4
Bromodomain-containing protein 4

2

8

High-throughput

0.584

High

1043571

CUL4B
Cullin-4B

2

11

Small-scale

0.584

High

1117700

ARI4B
AT-rich interactive domain-containing protein 4B

2

12

Small-scale

0.584

High

1327624

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

2

5

Small-scale

0.584

High

1327639

HECD1
E3 ubiquitin-protein ligase HECTD1

2

10

High-throughput

0.584

High

1314318

MAD3
Max dimerization protein 3

2

12

High-throughput

0.574

High

1024220

CSN1
COP9 signalosome complex subunit 1

1

2

Small-scale

0.561

High

1260538

GATD1
GATA zinc finger domain-containing protein 1

2

0

High-throughput

0.559

High

309051

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.536

High

358887

CRYAA
Alpha-crystallin A chain

1

4

High-throughput

0.536

High

666506

ARI4A
AT-rich interactive domain-containing protein 4A

1

10

High-throughput

0.536

High

952871

FOXK1
Forkhead box protein K1

1

11

High-throughput

0.536

High

997895

RBBP4
Histone-binding protein RBBP4

1

7

High-throughput

0.536

High

1050774

FHL2
Four and a half LIM domains protein 2

1

17

High-throughput

0.536

High

1216209

TF2LX
Homeobox protein TGIF2LX

1

7

High-throughput

0.536

High

1326059

TGIF2
Homeobox protein TGIF2

1

5

High-throughput

0.536

High

1327627

PRDM5
PR domain zinc finger protein 5

1

1

High-throughput

0.536

High

1327633

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

1327636

ING1
Inhibitor of growth protein 1

1

14

High-throughput

0.536

High

1327640

TPX2
Targeting protein for Xklp2

1

5

High-throughput

0.536

High

1041464

CUL2
Cullin-2

1

11

Small-scale

0.512

High

950277

SMAD3
Mothers against decapentaplegic homolog 3

1

4

High-throughput

0.508

High

1273867

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.501

High

849740

CCR9
C-C chemokine receptor type 9

1

2

High-throughput

0.494

High

591409

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

3

High-throughput

0.489

High

171075

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

182899

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

198051

PHF1
PHD finger protein 1

1

6

High-throughput

0.479

High

233887

HBP1
HMG box-containing protein 1

1

16

High-throughput

0.479

High

268275

EED
Polycomb protein EED

1

12

High-throughput

0.479

High

268861

SF3B1
Splicing factor 3B subunit 1

1

6

Small-scale

0.479

High

296131

MTA2
Metastasis-associated protein MTA2

1

9

High-throughput

0.479

High

316986

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

328653

MBD3
Methyl-CpG-binding domain protein 3

1

3

High-throughput

0.479

High

435172

SP1
Transcription factor Sp1

1

14

High-throughput

0.479

High

443247

NFIC
Nuclear factor 1 C-type

1

14

High-throughput

0.479

High

486965

MYBB
Myb-related protein B

1

3

High-throughput

0.479

High

487749

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

488023

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

555641

H2AX
Histone H2AX

1

7

High-throughput

0.479

High

570055

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

595954

HNF1A
Hepatocyte nuclear factor 1-alpha

1

16

High-throughput

0.479

High

620200

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

620420

GATA2
Endothelial transcription factor GATA-2

1

6

High-throughput

0.479

High

641557

PAX6
Paired box protein Pax-6

1

14

High-throughput

0.479

High

658730

SMCA1
Probable global transcription activator SNF2L1

1

9

High-throughput

0.479

High

668968

PML
Protein PML

1

11

Small-scale

0.479

High

679167

TLX1
T-cell leukemia homeobox protein 1

1

15

High-throughput

0.479

High

727584

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

727801

SOX5
Transcription factor SOX-5

1

18

High-throughput

0.479

High

727920

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

772156

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

782650

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

808910

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

824370

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

10

High-throughput

0.479

High

831674

CEBPA
CCAAT/enhancer-binding protein alpha

1

15

High-throughput

0.479

High

884235

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

917894

H4
Histone H4

1

8

High-throughput

0.479

High

952615

H33
Histone H3.3

1

16

Small-scale

0.479

High

966286

TFAP4
Transcription factor AP-4

1

2

Small-scale

0.479

High

980870

TLE3
Transducin-like enhancer protein 3

1

11

High-throughput

0.479

High

985257

HME1
Homeobox protein engrailed-1

1

6

High-throughput

0.479

High

1017348

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.479

High

1018688

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

8

High-throughput

0.479

High

1019123

TP53B
TP53-binding protein 1

1

12

High-throughput

0.479

High

1024515

CAF1A
Chromatin assembly factor 1 subunit A

1

5

High-throughput

0.479

High

1024878

KLF10
Krueppel-like factor 10

1

9

High-throughput

0.479

High

1027250

CBX3
Chromobox protein homolog 3

1

4

High-throughput

0.479

High

1031944

MTA1
Metastasis-associated protein MTA1

1

9

High-throughput

0.479

High

1041192

CUL1
Cullin-1

1

11

Small-scale

0.479

High

1043209

CUL4A
Cullin-4A

1

11

Small-scale

0.479

High

1046661

KLF9
Krueppel-like factor 9

1

17

High-throughput

0.479

High

1060364

NFIX
Nuclear factor 1 X-type

1

14

High-throughput

0.479

High

1077595

ELF2
ETS-related transcription factor Elf-2

1

12

High-throughput

0.479

High

1082382

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.479

High

1129655

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

5

High-throughput

0.479

High

1139033

TAF3
Transcription initiation factor TFIID subunit 3

1

12

Small-scale

0.479

High

1188842

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

9

High-throughput

0.479

High

1205812

P66A
Transcriptional repressor p66-alpha

1

4

High-throughput

0.479

High

1221725

SMC5
Structural maintenance of chromosomes protein 5

1

8

High-throughput

0.479

High

1254916

SP7
Transcription factor Sp7

1

17

High-throughput

0.479

High

1255044

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

8

High-throughput

0.479

High

1263969

P66B
Transcriptional repressor p66-beta

1

4

High-throughput

0.479

High

1269569

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1272602

CSN5
COP9 signalosome complex subunit 5

1

9

Small-scale

0.479

High

1298456

PWP2A
PWWP domain-containing protein 2A

1

5

High-throughput

0.479

High

1300934

CIC
Protein capicua homolog

1

18

High-throughput

0.479

High

1302440

SIN3A
Paired amphipathic helix protein Sin3a

1

6

Small-scale

0.479

High

1312019

MTA3
Metastasis-associated protein MTA3

1

10

High-throughput

0.479

High

1315348

KLF16
Krueppel-like factor 16

1

17

High-throughput

0.479

High

1319434

BC11B
B-cell lymphoma/leukemia 11B

1

4

High-throughput

0.479

High

1327623

BC11A
B-cell lymphoma/leukemia 11A

1

3

High-throughput

0.479

High

1327625

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

1327628

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.479

High

1327630

ZN219
Zinc finger protein 219

1

3

High-throughput

0.479

High

1327631

MBD2
Methyl-CpG-binding domain protein 2

1

3

High-throughput

0.479

High

1327635

KLF15
Krueppel-like factor 15

1

19

High-throughput

0.479

High

1327638

BRPF3
Bromodomain and PHD finger-containing protein 3

1

5

High-throughput

0.479

High

1327641

ASF1A
Histone chaperone ASF1A

1

4

High-throughput

0.479

High

1327642

MTF2
Metal-response element-binding transcription factor 2

1

6

High-throughput

0.479

High

146863

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.458

High

158851

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

266502

SUPT3
Transcription initiation protein SPT3 homolog

1

0

Small-scale

0.458

High

1256237

SAP25
Histone deacetylase complex subunit SAP25

1

0

Small-scale

0.458

High

1292968

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.458

High

1327629

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

568520

SYN1
Synapsin-1

1

9

High-throughput

0.437

High

839118

EMD
Emerin

1

3

Small-scale

0.437

High

878460

PAX9
Paired box protein Pax-9

1

14

High-throughput

0.437

High

995210

GOGA2
Golgin subfamily A member 2

1

4

High-throughput

0.437

High

1061783

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

13

High-throughput

0.437

High

1137048

LIN9
Protein lin-9 homolog

1

3

High-throughput

0.437

High

1244695

NUP35
Nucleoporin NUP35

1

3

High-throughput

0.437

High

1296242

Z512B
Zinc finger protein 512B

1

4

High-throughput

0.437

High

1314378

DDA1
DET1- and DDB1-associated protein 1

1

2

High-throughput

0.437

High

1327634

HMGX4
HMG domain-containing protein 4

1

17

High-throughput

0.437

High

1327637

NUP50
Nuclear pore complex protein Nup50

1

1

High-throughput

0.437

High

1021641

TAF10
Transcription initiation factor TFIID subunit 10

1

0

Small-scale

0.426

High

1297320

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.279

Low

1327632

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.279

Low

928684

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

1072449

ELOB
Elongin-B

1

0

Small-scale

0.249

Low

1221072

BAP18
Chromatin complexes subunit BAP18

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024