Protein: IRS2
Insulin receptor substrate 2 (IRS-2)

Gene: IRS2
Organism: Homo sapiens
Interactions: 68
UniProt ID: Q9Y4H2

Gene Ontology (top 5):
GO:0002053 - positive regulation of mesenchymal cell proliferation
GO:0002903 - negative regulation of B cell apoptotic process
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 - insulin receptor binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

411534

INSR
Insulin receptor

3

20

Small-scale

0.854

High

924983

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.777

High

655516

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

12

17

Small-scale

0.755

High

616892

JAK1
Tyrosine-protein kinase JAK1

2

20

Small-scale

0.754

High

1031729

GRB10
Growth factor receptor-bound protein 10

2

20

Small-scale

0.754

High

683852

1433B
14-3-3 protein beta/alpha

6

20

High-throughput

0.736

High

581086

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

2

3

Small-scale

0.727

High

647417

1433T
14-3-3 protein theta

5

20

High-throughput

0.718

High

927703

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.718

High

905303

1433G
14-3-3 protein gamma

5

20

High-throughput

0.718

High

982659

1433F
14-3-3 protein eta

5

20

High-throughput

0.716

High

1267462

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

3

20

Small-scale

0.667

High

910201

1433E
14-3-3 protein epsilon

3

8

Small-scale

0.657

High

669214

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.647

High

943044

SRPK2
SRSF protein kinase 2

1

11

High-throughput

0.647

High

1230076

RPTOR
Regulatory-associated protein of mTOR

1

10

Small-scale

0.647

High

1289481

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

8

Small-scale

0.641

High

181903

SOCS1
Suppressor of cytokine signaling 1

3

20

Small-scale

0.640

High

787336

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

3

8

Small-scale

0.633

High

158574

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

8

Small-scale

0.618

High

339187

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

385782

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.618

High

547293

EZRI
Ezrin

1

5

High-throughput

0.618

High

616734

KS6B1
Ribosomal protein S6 kinase beta-1

1

11

Small-scale

0.618

High

862003

PLK1
Serine/threonine-protein kinase PLK1

1

8

High-throughput

0.618

High

916096

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1344702

SH2B1
SH2B adapter protein 1

1

20

Small-scale

0.618

High

1356382

FBW1B
F-box/WD repeat-containing protein 11

1

8

High-throughput

0.618

High

1377256

NISCH
Nischarin

1

7

Small-scale

0.618

High

684422

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

435810

IGF1R
Insulin-like growth factor 1 receptor

1

19

Small-scale

0.590

High

151268

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

8

Small-scale

0.584

High

808336

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

7

Small-scale

0.578

High

718359

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.536

High

1332816

EGLN3
Prolyl hydroxylase EGLN3

1

5

High-throughput

0.536

High

1287548

AP2M1
AP-2 complex subunit mu

1

1

High-throughput

0.501

High

1241179

NETO2
Neuropilin and tolloid-like protein 2

1

1

High-throughput

0.489

High

147455

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.479

High

163517

XPO1
Exportin-1

1

4

High-throughput

0.479

High

196375

PJA2
E3 ubiquitin-protein ligase Praja-2

1

2

Small-scale

0.479

High

370801

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

377829

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

489470

BCL2
Apoptosis regulator Bcl-2

1

3

Small-scale

0.479

High

554147

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

581177

EPOR
Erythropoietin receptor

1

5

Small-scale

0.479

High

787612

MTOR
Serine/threonine-protein kinase mTOR

1

6

Small-scale

0.479

High

840616

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

906216

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

6

High-throughput

0.479

High

986064

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

9

Small-scale

0.479

High

1038846

HDAC1
Histone deacetylase 1

1

11

High-throughput

0.479

High

1042920

CUL3
Cullin-3

1

12

High-throughput

0.479

High

1064895

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

1200783

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1244016

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

1273773

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

Small-scale

0.479

High

1273987

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

Small-scale

0.479

High

1348350

MTMR4
Myotubularin-related protein 4

1

2

High-throughput

0.479

High

1356832

BRPF3
Bromodomain and PHD finger-containing protein 3

1

10

High-throughput

0.479

High

1377845

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

6

Small-scale

0.479

High

1377856

EPN1
Epsin-1

1

4

Small-scale

0.479

High

1239781

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

164514

TRI66
Tripartite motif-containing protein 66

1

13

High-throughput

0.437

High

232613

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.437

High

567792

UBF1
Nucleolar transcription factor 1

1

9

Small-scale

0.437

High

652705

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

1285406

PF21A
PHD finger protein 21A

1

14

High-throughput

0.437

High

517559

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.417

High

1316648

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024