Protein: TPR
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)

Gene: TPR
Organism: Homo sapiens
Interactions: 170
UniProt ID: P12270

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000776 - kinetochore
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

518839

NU153
Nuclear pore complex protein Nup153

4

20

Small-scale

0.703

High

359607

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

19

High-throughput

0.672

High

518887

ZC3C1
Zinc finger C3HC-type protein 1

3

1

Small-scale

0.669

High

518940

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

3

19

Small-scale

0.665

High

518844

NU107
Nuclear pore complex protein Nup107

3

5

Small-scale

0.656

High

518878

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

3

10

Small-scale

0.624

High

518863

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

1

Small-scale

0.611

High

518822

MK01
Mitogen-activated protein kinase 1

2

4

Small-scale

0.602

High

518845

SUMO2
Small ubiquitin-related modifier 2

2

4

High-throughput

0.602

High

518842

NUP98
Nuclear pore complex protein Nup98-Nup96

2

20

Small-scale

0.595

High

243855

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

322124

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

15

High-throughput

0.584

High

345802

MYC
Myc proto-oncogene protein

2

16

High-throughput

0.584

High

518830

BRCA1
Breast cancer type 1 susceptibility protein

2

17

High-throughput

0.584

High

518833

YAP1
Transcriptional coactivator YAP1

2

20

Small-scale

0.584

High

518898

COP1
E3 ubiquitin-protein ligase COP1

2

20

Small-scale

0.584

High

204978

TGON2
Trans-Golgi network integral membrane protein 2

2

11

High-throughput

0.571

High

518817

RAB5A
Ras-related protein Rab-5A

2

12

High-throughput

0.571

High

518821

CALX
Calnexin

2

6

High-throughput

0.571

High

518840

CDK7
Cyclin-dependent kinase 7

2

20

High-throughput

0.571

High

518856

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

20

High-throughput

0.571

High

518895

DOCK8
Dedicator of cytokinesis protein 8

2

4

High-throughput

0.571

High

518819

APC
Adenomatous polyposis coli protein

1

12

High-throughput

0.541

High

518942

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

7

High-throughput

0.541

High

327827

CBX7
Chromobox protein homolog 7

1

16

High-throughput

0.536

High

336336

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.536

High

440319

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

8

High-throughput

0.536

High

518809

CFTR
Cystic fibrosis transmembrane conductance regulator

1

16

High-throughput

0.536

High

518823

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

10

High-throughput

0.536

High

518836

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.536

High

518853

FOXK2
Forkhead box protein K2

1

10

High-throughput

0.536

High

518861

ILF3
Interleukin enhancer-binding factor 3

1

17

High-throughput

0.536

High

518880

ULK3
Serine/threonine-protein kinase ULK3

1

7

High-throughput

0.536

High

518892

RYBP
RING1 and YY1-binding protein

1

3

High-throughput

0.536

High

518901

DUS19
Dual specificity protein phosphatase 19

1

9

High-throughput

0.536

High

518902

STYX
Serine/threonine/tyrosine-interacting protein

1

9

Small-scale

0.536

High

518914

CDC5L
Cell division cycle 5-like protein

1

7

High-throughput

0.536

High

518937

HDAC9
Histone deacetylase 9

1

20

High-throughput

0.536

High

508307

TOP1
DNA topoisomerase 1

1

5

High-throughput

0.515

High

518832

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

10

High-throughput

0.515

High

518881

NFXL1
NF-X1-type zinc finger protein NFXL1

1

1

High-throughput

0.515

High

518900

ZN721
Zinc finger protein 721

1

1

High-throughput

0.515

High

518903

PHIP
PH-interacting protein

1

20

High-throughput

0.515

High

518912

ADCYA
Adenylate cyclase type 10

1

1

High-throughput

0.515

High

518915

MNT
Max-binding protein MNT

1

20

High-throughput

0.515

High

518888

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.513

High

414704

CDK1
Cyclin-dependent kinase 1

1

19

Small-scale

0.501

High

518814

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

17

Small-scale

0.501

High

518858

ERCC6
DNA excision repair protein ERCC-6

1

20

High-throughput

0.501

High

518907

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

17

High-throughput

0.501

High

282505

RNF8
E3 ubiquitin-protein ligase RNF8

1

14

Small-scale

0.500

High

518877

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.493

High

362757

FINC
Fibronectin

1

4

High-throughput

0.489

High

518825

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

2

High-throughput

0.489

High

518834

CAPZB
F-actin-capping protein subunit beta

1

5

High-throughput

0.489

High

518848

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.489

High

518860

CALD1
Caldesmon

1

19

High-throughput

0.489

High

518918

REEP2
Receptor expression-enhancing protein 2

1

1

High-throughput

0.489

High

518919

LZTS2
Leucine zipper putative tumor suppressor 2

1

19

High-throughput

0.489

High

331196

CHK2
Serine/threonine-protein kinase Chk2

1

18

Small-scale

0.484

High

518857

MECOM
Histone-lysine N-methyltransferase MECOM

1

9

High-throughput

0.481

High

162373

XPO1
Exportin-1

1

10

Small-scale

0.479

High

209625

PRC1
Protein regulator of cytokinesis 1

1

17

High-throughput

0.479

High

224285

RAD21
Double-strand-break repair protein rad21 homolog

1

2

High-throughput

0.479

High

226381

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.479

High

231982

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

232775

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

14

High-throughput

0.479

High

233182

NUPR1
Nuclear protein 1

1

5

High-throughput

0.479

High

255468

OBSL1
Obscurin-like protein 1

1

12

High-throughput

0.479

High

267867

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

331711

NSD2
Histone-lysine N-methyltransferase NSD2

1

17

Small-scale

0.479

High

345297

FOS
Protein c-Fos

1

7

High-throughput

0.479

High

378961

MYCN
N-myc proto-oncogene protein

1

17

High-throughput

0.479

High

384180

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

417891

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

430023

PROF1
Profilin-1

1

4

Small-scale

0.479

High

487084

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

518807

TPR
Nucleoprotein TPR

1

19

High-throughput

0.479

High

518808

XRCC6
X-ray repair cross-complementing protein 6

1

6

High-throughput

0.479

High

518811

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

518815

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

518820

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

518826

MERL
Merlin

1

20

High-throughput

0.479

High

518827

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

518828

NU214
Nuclear pore complex protein Nup214

1

19

Small-scale

0.479

High

518829

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

518831

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

518838

MCM2
DNA replication licensing factor MCM2

1

20

High-throughput

0.479

High

518841

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.479

High

518843

HDAC4
Histone deacetylase 4

1

20

High-throughput

0.479

High

518846

WDR5
WD repeat-containing protein 5

1

20

High-throughput

0.479

High

518847

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

518849

ACTC
Actin, alpha cardiac muscle 1

1

19

High-throughput

0.479

High

518850

H31
Histone H3.1

1

15

High-throughput

0.479

High

518851

RED1
Double-stranded RNA-specific editase 1

1

14

High-throughput

0.479

High

518854

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

518859

KPCZ
Protein kinase C zeta type

1

14

High-throughput

0.479

High

518862

FOXC1
Forkhead box protein C1

1

10

High-throughput

0.479

High

518864

BIRC3
Baculoviral IAP repeat-containing protein 3

1

11

High-throughput

0.479

High

518865

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

518866

CUL4A
Cullin-4A

1

16

High-throughput

0.479

High

518867

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

High-throughput

0.479

High

518869

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

17

High-throughput

0.479

High

518870

CUL7
Cullin-7

1

11

High-throughput

0.479

High

518872

PAF15
PCNA-associated factor

1

1

Small-scale

0.479

High

518873

TNIP1
TNFAIP3-interacting protein 1

1

19

High-throughput

0.479

High

518874

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

9

High-throughput

0.479

High

518876

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.479

High

518879

VIR
Protein virilizer homolog

1

6

High-throughput

0.479

High

518882

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

518883

MOB3C
MOB kinase activator 3C

1

3

High-throughput

0.479

High

518884

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

518885

SLN11
Schlafen family member 11

1

5

High-throughput

0.479

High

518886

NAA40
N-alpha-acetyltransferase 40

1

6

High-throughput

0.479

High

518890

SMC5
Structural maintenance of chromosomes protein 5

1

17

High-throughput

0.479

High

518891

NUP93
Nuclear pore complex protein Nup93

1

4

Small-scale

0.479

High

518899

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

518905

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

12

High-throughput

0.479

High

518906

NU205
Nuclear pore complex protein Nup205

1

6

Small-scale

0.479

High

518908

PF21A
PHD finger protein 21A

1

20

High-throughput

0.479

High

518909

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

518911

NSUN5
28S rRNA

1

3

High-throughput

0.479

High

518916

NECD
Necdin

1

10

High-throughput

0.479

High

518917

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

518921

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.479

High

518923

REN3B
Regulator of nonsense transcripts 3B

1

4

High-throughput

0.479

High

518925

CCDC8
Coiled-coil domain-containing protein 8

1

7

High-throughput

0.479

High

518926

TXNIP
Thioredoxin-interacting protein

1

7

Small-scale

0.479

High

518928

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

518929

KAT8
Histone acetyltransferase KAT8

1

5

Small-scale

0.479

High

518930

ANLN
Anillin

1

11

High-throughput

0.479

High

518931

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.479

High

518933

PD1L1
Programmed cell death 1 ligand 1

1

5

High-throughput

0.479

High

518934

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

518935

TBK1
Serine/threonine-protein kinase TBK1

1

20

High-throughput

0.479

High

518936

RCOR1
REST corepressor 1

1

8

High-throughput

0.479

High

518938

FBW1A
F-box/WD repeat-containing protein 1A

1

17

High-throughput

0.479

High

518939

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.479

High

518941

NCOA3
Nuclear receptor coactivator 3

1

9

Small-scale

0.479

High

398321

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.470

High

518835

NPY2R
Neuropeptide Y receptor type 2

1

1

High-throughput

0.470

High

518910

MRP9
ATP-binding cassette sub-family C member 12

1

3

High-throughput

0.470

High

518812

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.458

High

518824

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.458

High

518837

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

518871

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

518897

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

518875

SF01
Splicing factor 1

1

3

High-throughput

0.457

High

518896

NUP37
Nucleoporin Nup37

1

20

Small-scale

0.457

High

383567

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

5

High-throughput

0.445

High

401325

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

518855

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

518889

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.445

High

518924

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

148338

CTRO
Citron Rho-interacting kinase

1

17

High-throughput

0.437

High

518810

ITA4
Integrin alpha-4

1

4

High-throughput

0.437

High

518868

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

518904

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.437

High

518920

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

518922

ACE2
Angiotensin-converting enzyme 2

1

9

High-throughput

0.437

High

518932

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

6

High-throughput

0.437

High

518816

VCAM1
Vascular cell adhesion protein 1

1

6

High-throughput

0.407

High

518818

FGFR3
Fibroblast growth factor receptor 3

1

7

High-throughput

0.407

High

518927

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

6

High-throughput

0.407

High

518852

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.391

High

518893

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

518813

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.269

Low

518894

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

518913

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024