Protein: PPME1
Protein phosphatase methylesterase 1 (PME-1) (EC 3.1.1.89)

Gene: PPME1
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9Y570

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004864 - protein phosphatase inhibitor activity
GO:0005654 - nucleoplasm
GO:0006482 - protein demethylation
GO:0019888 - protein phosphatase regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

931054

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

11

4

Small-scale

0.879

High

915315

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

7

4

Small-scale

0.866

High

891018

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

2

3

High-throughput

0.789

High

672372

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

8

1

Small-scale

0.752

High

1146405

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

5

2

High-throughput

0.723

High

1348147

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

4

0

High-throughput

0.672

High

1058721

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

3

1

High-throughput

0.667

High

958799

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

2

High-throughput

0.635

High

1377935

PPME1
Protein phosphatase methylesterase 1

1

5

Small-scale

0.618

High

927909

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

2

Small-scale

0.611

High

664150

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

1153070

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

2

0

High-throughput

0.602

High

229174

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

505012

HSP7C
Heat shock cognate 71 kDa protein

2

0

Small-scale

0.559

High

542766

ETS2
Protein C-ets-2

1

1

High-throughput

0.541

High

647716

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

1069282

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

1

High-throughput

0.536

High

213755

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

258261

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

1235729

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.513

High

1261518

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1295926

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

1346455

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1355620

PUF60
Poly(U)-binding-splicing factor PUF60

1

0

High-throughput

0.513

High

1377263

NTNG1
Netrin-G1

1

1

High-throughput

0.489

High

241666

H2B1K
Histone H2B type 1-K

1

1

High-throughput

0.479

High

334316

LDHA
L-lactate dehydrogenase A chain

1

2

Small-scale

0.479

High

522291

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

538457

ENPL
Endoplasmin

1

1

Small-scale

0.479

High

542090

ETS1
Protein C-ets-1

1

1

High-throughput

0.479

High

918794

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

984687

CALD1
Caldesmon

1

2

High-throughput

0.479

High

1030130

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

Small-scale

0.479

High

149468

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

360579

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.458

High

517562

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

531310

EF2
Elongation factor 2

1

0

Small-scale

0.458

High

536655

FPPS
Farnesyl pyrophosphate synthase

1

0

Small-scale

0.458

High

538069

KPYM
Pyruvate kinase PKM

1

0

Small-scale

0.458

High

547297

EZRI
Ezrin

1

0

Small-scale

0.458

High

554157

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

587761

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.458

High

598392

FLNA
Filamin-A

1

0

Small-scale

0.458

High

627400

MCM3
DNA replication licensing factor MCM3

1

0

Small-scale

0.458

High

652716

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

667001

TKT
Transketolase

1

0

Small-scale

0.458

High

669500

EF1D
Elongation factor 1-delta

1

0

Small-scale

0.458

High

721882

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

749991

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

809496

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

824585

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

874619

XPO2
Exportin-2

1

0

Small-scale

0.458

High

919320

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

961034

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.458

High

1030063

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.458

High

1200786

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1244149

SYNE1
Nesprin-1

1

0

Small-scale

0.458

High

1272736

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1281889

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1329034

CAD23
Cadherin-23

1

0

Small-scale

0.458

High

1355001

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1377047

RUVB1
RuvB-like 1

1

0

Small-scale

0.458

High

1377061

NUDC
Nuclear migration protein nudC

1

0

Small-scale

0.458

High

1153475

PKHA7
Pleckstrin homology domain-containing family A member 7

1

1

High-throughput

0.445

High

403700

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.438

High

422123

LDHB
L-lactate dehydrogenase B chain

1

2

Small-scale

0.437

High

423403

PDIA1
Protein disulfide-isomerase

1

2

Small-scale

0.437

High

532034

PDIA4
Protein disulfide-isomerase A4

1

2

Small-scale

0.437

High

671970

PDIA3
Protein disulfide-isomerase A3

1

2

Small-scale

0.437

High

777809

MDHM
Malate dehydrogenase, mitochondrial

1

2

Small-scale

0.437

High

780390

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

1030575

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.437

High

1172434

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1206213

HORN
Hornerin

1

1

Small-scale

0.437

High

1232426

CMYA5
Cardiomyopathy-associated protein 5

1

3

Small-scale

0.437

High

1132193

S1A7B
Protein S100-A7-like 2

1

2

High-throughput

0.407

High

831849

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

975207

ACY1
Aminoacylase-1

3

0

High-throughput

0.347

High

994036

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

0

High-throughput

0.319

High

888141

RNAS9
Inactive ribonuclease-like protein 9

1

0

High-throughput

0.279

Low

1288206

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.279

Low

1314663

SSBP4
Single-stranded DNA-binding protein 4

1

0

High-throughput

0.279

Low

1327231

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

0

High-throughput

0.279

Low

1336291

AGO4
Protein argonaute-4

1

0

High-throughput

0.279

Low

1346167

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.279

Low

1354110

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1355486

PGAP2
Post-GPI attachment to proteins factor 2

1

0

High-throughput

0.279

Low

1377936

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

1047965

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

0

Small-scale

0.261

Low

254140

WDR1
WD repeat-containing protein 1

1

0

Small-scale

0.249

Low

382192

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.249

Low

385792

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

417782

G6PI
Glucose-6-phosphate isomerase

1

0

Small-scale

0.249

Low

427141

CATD
Cathepsin D

1

0

Small-scale

0.249

Low

436122

ANXA6
Annexin A6

1

0

Small-scale

0.249

Low

522584

MYH1
Myosin-1

1

0

Small-scale

0.249

Low

533260

PLSL
Plastin-2

1

0

Small-scale

0.249

Low

653778

CALR
Calreticulin

1

0

Small-scale

0.249

Low

943966

GSTO1
Glutathione S-transferase omega-1

1

0

Small-scale

0.249

Low

995479

LG3BP
Galectin-3-binding protein

1

0

Small-scale

0.249

Low

1065600

SYK
Lysine--tRNA ligase

1

0

Small-scale

0.249

Low

1155930

LRC8E
Volume-regulated anion channel subunit LRRC8E

1

0

Small-scale

0.249

Low

1189110

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1266616

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.249

Low

1315460

CAR14
Caspase recruitment domain-containing protein 14

1

0

Small-scale

0.249

Low

1315768

TDRD1
Tudor domain-containing protein 1

1

0

High-throughput

0.249

Low

483734

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

1130775

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024