Protein: M3K4
Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)

Gene: M3K4, MAP3K4
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q9Y6R4

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001890 - placenta development
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

854749

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

6

16

Small-scale

0.952

High

801008

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

3

18

Small-scale

0.868

High

805498

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

17

Small-scale

0.818

High

892148

ACTB
Actin, cytoplasmic 1

2

9

High-throughput

0.811

High

986407

BTK
Tyrosine-protein kinase BTK

2

4

High-throughput

0.811

High

1122543

ACTBL
Beta-actin-like protein 2

2

9

High-throughput

0.811

High

800855

MK08
Mitogen-activated protein kinase 8

2

16

Small-scale

0.768

High

1378229

M3K4
Mitogen-activated protein kinase kinase kinase 4

2

16

Small-scale

0.757

High

258882

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

4

2

Small-scale

0.707

High

380892

S100B
Protein S100-B

1

2

High-throughput

0.691

High

915545

ACTA
Actin, aortic smooth muscle

1

10

High-throughput

0.691

High

930075

ACTG
Actin, cytoplasmic 2

1

9

High-throughput

0.691

High

1285236

SH3K1
SH3 domain-containing kinase-binding protein 1

3

7

Small-scale

0.675

High

153200

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

16

Small-scale

0.647

High

167644

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.647

High

836135

GSK3B
Glycogen synthase kinase-3 beta

1

20

Small-scale

0.647

High

894645

CDC42
Cell division control protein 42 homolog

1

2

Small-scale

0.647

High

925778

RAC1
Ras-related C3 botulinum toxin substrate 1

1

2

Small-scale

0.647

High

972280

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

18

Small-scale

0.647

High

309892

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

2

2

Small-scale

0.644

High

622989

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

2

2

Small-scale

0.636

High

257124

DJC13
DnaJ homolog subfamily C member 13

1

8

High-throughput

0.618

High

1031129

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

2

High-throughput

0.618

High

149480

CTRO
Citron Rho-interacting kinase

1

13

High-throughput

0.618

High

170746

AXIN1
Axin-1

1

10

Small-scale

0.618

High

201842

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

8

Small-scale

0.618

High

780416

CCNF
Cyclin-F

1

3

High-throughput

0.618

High

803832

BAG6
Large proline-rich protein BAG6

1

8

High-throughput

0.618

High

1048306

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

High-throughput

0.618

High

1052849

FAK2
Protein-tyrosine kinase 2-beta

1

3

Small-scale

0.618

High

1083073

CDC37
Hsp90 co-chaperone Cdc37

1

6

Small-scale

0.618

High

1172498

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.618

High

1331778

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.618

High

1357283

ALK
ALK tyrosine kinase receptor

1

7

Small-scale

0.618

High

476663

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

15

Small-scale

0.595

High

929752

RACK1
Small ribosomal subunit protein RACK1

2

11

Small-scale

0.584

High

1313394

TRAF4
TNF receptor-associated factor 4

2

10

Small-scale

0.584

High

1355378

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.575

High

236156

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.553

High

897978

RAP1B
Ras-related protein Rap-1b

1

3

High-throughput

0.553

High

1206100

MIB1
E3 ubiquitin-protein ligase MIB1

1

2

Small-scale

0.553

High

518942

TPR
Nucleoprotein TPR

1

7

High-throughput

0.541

High

927721

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.541

High

1192550

CNTRL
Centriolin

1

5

High-throughput

0.541

High

1377839

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

3

High-throughput

0.536

High

326362

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

1

High-throughput

0.536

High

1302200

TCPQM
T-complex protein 1 subunit theta-like 2

1

6

High-throughput

0.536

High

261350

FLNB
Filamin-B

1

7

Small-scale

0.500

High

920598

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.493

High

210405

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

324704

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

325480

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

Small-scale

0.479

High

427709

ANXA2
Annexin A2

1

2

Small-scale

0.479

High

644361

TTP
mRNA decay activator protein ZFP36

1

2

Small-scale

0.479

High

970109

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

1101565

KIF7
Kinesin-like protein KIF7

1

3

High-throughput

0.479

High

1190626

KI21A
Kinesin-like protein KIF21A

1

4

High-throughput

0.479

High

1230207

CNTRB
Centrobin

1

6

High-throughput

0.479

High

1304368

SORT
Sortilin

1

1

High-throughput

0.479

High

1355060

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1048926

BOP1
Ribosome biogenesis protein BOP1

1

3

High-throughput

0.470

High

1023032

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.458

High

1344695

PICK1
PRKCA-binding protein

1

6

High-throughput

0.457

High

438899

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.437

High

607854

USF1
Upstream stimulatory factor 1

1

2

High-throughput

0.437

High

897675

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

1

High-throughput

0.437

High

1030080

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

1246063

NEDD1
Protein NEDD1

1

3

High-throughput

0.437

High

1290192

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

10

High-throughput

0.437

High

1302611

INT14
Integrator complex subunit 14

1

1

High-throughput

0.437

High

1357661

AP4E1
AP-4 complex subunit epsilon-1

1

3

High-throughput

0.437

High

1377684

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.437

High

665975

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

3

Small-scale

0.408

High

1237343

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.328

High

1139307

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1236599

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.249

Low

1244025

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024