Protein: AP2S1
AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)

Gene: AP2S1
Organism: Homo sapiens
Interactions: 103
UniProt ID: P53680

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006886 - intracellular protein transport
GO:0009898 - cytoplasmic side of plasma membrane
GO:0016192 - vesicle-mediated transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

864097

AP2M1
AP-2 complex subunit mu

6

19

High-throughput

0.950

High

321516

AP2A1
AP-2 complex subunit alpha-1

4

20

Small-scale

0.914

High

864065

AP2B1
AP-2 complex subunit beta

4

20

High-throughput

0.903

High

302125

AP2A2
AP-2 complex subunit alpha-2

3

20

High-throughput

0.871

High

864070

AP1B1
AP-1 complex subunit beta-1

2

20

High-throughput

0.811

High

864094

STON2
Stonin-2

2

19

High-throughput

0.811

High

864083

AAGAB
Alpha- and gamma-adaptin-binding protein p34

9

2

Small-scale

0.757

High

787877

EPS15
Epidermal growth factor receptor substrate 15

4

11

High-throughput

0.704

High

864078

AAK1
AP2-associated protein kinase 1

4

9

High-throughput

0.699

High

864109

NECP2
Adaptin ear-binding coat-associated protein 2

4

6

High-throughput

0.699

High

338175

EGFR
Epidermal growth factor receptor

4

15

Small-scale

0.694

High

864069

FCHO2
F-BAR domain only protein 2

3

3

High-throughput

0.675

High

864075

RBP1
RalA-binding protein 1

3

6

High-throughput

0.675

High

864076

ITSN1
Intersectin-1

3

9

High-throughput

0.675

High

864112

EP15R
Epidermal growth factor receptor substrate 15-like 1

3

12

High-throughput

0.675

High

369240

ESR1
Estrogen receptor

3

8

High-throughput

0.650

High

864107

BMP2K
BMP-2-inducible protein kinase

4

12

High-throughput

0.638

High

474966

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

11

High-throughput

0.628

High

827731

AMPH
Amphiphysin

2

3

High-throughput

0.628

High

864080

RUN3A
RUN domain-containing protein 3A

2

6

High-throughput

0.628

High

864090

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

3

High-throughput

0.628

High

864098

REPS1
RalBP1-associated Eps domain-containing protein 1

2

19

High-throughput

0.628

High

212608

AP1G1
AP-1 complex subunit gamma-1

1

20

Small-scale

0.618

High

864101

CCD32
Coiled-coil domain-containing protein 32

3

1

High-throughput

0.616

High

475515

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

11

High-throughput

0.602

High

581569

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.601

High

150920

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

4

Small-scale

0.584

High

864106

GPBL1
Vasculin-like protein 1

2

1

High-throughput

0.574

High

666047

SHC1
SHC-transforming protein 1

2

11

High-throughput

0.571

High

864104

RNF41
E3 ubiquitin-protein ligase NRDP1

1

6

Small-scale

0.552

High

451400

CLCA
Clathrin light chain A

1

7

High-throughput

0.536

High

451654

CLCB
Clathrin light chain B

1

7

High-throughput

0.536

High

717594

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

864063

RAN
GTP-binding nuclear protein Ran

1

2

High-throughput

0.536

High

864064

GRB2
Growth factor receptor-bound protein 2

1

9

High-throughput

0.536

High

864067

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

2

High-throughput

0.536

High

864068

PLCB3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

1

1

High-throughput

0.536

High

864077

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.536

High

864091

NECP1
Adaptin ear-binding coat-associated protein 1

1

6

High-throughput

0.536

High

864096

ARHG1
Rho guanine nucleotide exchange factor 1

1

7

High-throughput

0.536

High

864100

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

5

High-throughput

0.536

High

864110

ITSN2
Intersectin-2

1

9

High-throughput

0.536

High

864119

SNX9
Sorting nexin-9

1

3

High-throughput

0.536

High

526884

TDGF1
Protein Cripto

1

0

High-throughput

0.518

High

864103

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.515

High

606387

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.513

High

864058

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.513

High

864073

NAA25
N-alpha-acetyltransferase 25, NatB auxiliary subunit

1

0

High-throughput

0.513

High

609774

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.489

High

864079

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

864092

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

864105

PAAT
ATPase PAAT

1

1

High-throughput

0.489

High

226953

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

264146

DPOLQ
DNA polymerase theta

1

1

High-throughput

0.479

High

373929

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

525878

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.479

High

530526

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

665183

EPHA2
Ephrin type-A receptor 2

1

7

Small-scale

0.479

High

726099

BASI
Basigin

1

1

High-throughput

0.479

High

742156

SYUA
Alpha-synuclein

1

2

High-throughput

0.479

High

864062

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

864071

CUL3
Cullin-3

1

3

High-throughput

0.479

High

864074

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.479

High

864081

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.479

High

864087

MIB1
E3 ubiquitin-protein ligase MIB1

1

5

High-throughput

0.479

High

864088

CUL9
Cullin-9

1

3

High-throughput

0.479

High

864089

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

864095

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

864111

PAK5
Serine/threonine-protein kinase PAK 5

1

5

High-throughput

0.479

High

864113

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

864114

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

864115

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

864116

MYO6
Unconventional myosin-VI

1

3

High-throughput

0.479

High

864118

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

3

Small-scale

0.479

High

352541

TNFA
Tumor necrosis factor

1

0

High-throughput

0.458

High

781532

CETN2
Centrin-2

1

0

High-throughput

0.458

High

837148

KHK
Ketohexokinase

1

0

High-throughput

0.458

High

864061

RAB25
Ras-related protein Rab-25

1

0

High-throughput

0.458

High

239872

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

496627

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

528820

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

833551

NUMB
Protein numb homolog

1

7

Small-scale

0.445

High

864060

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

864099

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

3

High-throughput

0.445

High

864102

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

233305

NUPR1
Nuclear protein 1

1

1

High-throughput

0.437

High

294571

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

346312

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

552318

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

650761

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

720052

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

864066

RNF4
E3 ubiquitin-protein ligase RNF4

1

3

High-throughput

0.437

High

864082

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

1

High-throughput

0.437

High

864084

CE128
Centrosomal protein of 128 kDa

1

3

High-throughput

0.437

High

864117

RNF11
RING finger protein 11

1

6

Small-scale

0.437

High

401689

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

864072

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.407

High

559029

H15
Histone H1.5

1

0

High-throughput

0.279

Low

864085

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

864108

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

1

0

High-throughput

0.279

Low

864059

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

864086

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

864093

DCA11
DDB1- and CUL4-associated factor 11

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024