Protein: M3K21
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)

Gene: M3K21, MAP3K21
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q5TCX8

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683421

1433B
14-3-3 protein beta/alpha

7

20

High-throughput

0.968

High

904685

1433G
14-3-3 protein gamma

5

20

High-throughput

0.932

High

927141

1433Z
14-3-3 protein zeta/delta

5

20

High-throughput

0.932

High

982110

1433F
14-3-3 protein eta

5

20

High-throughput

0.932

High

646976

1433T
14-3-3 protein theta

4

20

High-throughput

0.903

High

909655

1433E
14-3-3 protein epsilon

3

10

High-throughput

0.876

High

972461

M3K10
Mitogen-activated protein kinase kinase kinase 10

2

19

High-throughput

0.817

High

1034891

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

3

High-throughput

0.789

High

167563

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

12

Small-scale

0.747

High

1083509

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

18

Small-scale

0.724

High

945775

M3K9
Mitogen-activated protein kinase kinase kinase 9

1

18

High-throughput

0.691

High

1136484

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

4

0

High-throughput

0.667

High

833749

CLK1
Dual specificity protein kinase CLK1

1

4

High-throughput

0.647

High

158489

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

13

Small-scale

0.618

High

166570

DCLK1
Serine/threonine-protein kinase DCLK1

1

10

High-throughput

0.618

High

230878

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

6

High-throughput

0.618

High

253360

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

9

High-throughput

0.618

High

411757

LCK
Tyrosine-protein kinase Lck

1

20

High-throughput

0.618

High

433817

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

684098

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

960376

CDK16
Cyclin-dependent kinase 16

1

10

High-throughput

0.618

High

1136452

SPD2A
SH3 and PX domain-containing protein 2A

1

12

High-throughput

0.618

High

1136461

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

6

High-throughput

0.618

High

1136462

KSR1
Kinase suppressor of Ras 1

1

20

High-throughput

0.618

High

1136473

TESK2
Dual specificity testis-specific protein kinase 2

1

15

High-throughput

0.618

High

1136494

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

3

High-throughput

0.618

High

950455

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

12

High-throughput

0.611

High

1136479

RTKN
Rhotekin

1

0

High-throughput

0.586

High

1136477

SLX1
Structure-specific endonuclease subunit SLX1

2

1

High-throughput

0.574

High

740665

HPCL1
Hippocalcin-like protein 1

2

12

High-throughput

0.558

High

1022401

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

6

High-throughput

0.553

High

1136454

AN34A
Ankyrin repeat domain-containing protein 34A

1

3

High-throughput

0.553

High

1136456

PKHA7
Pleckstrin homology domain-containing family A member 7

1

19

High-throughput

0.553

High

1136460

PHLB2
Pleckstrin homology-like domain family B member 2

1

7

High-throughput

0.553

High

1136486

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

14

High-throughput

0.553

High

1136493

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.536

High

258064

DNJB6
DnaJ homolog subfamily B member 6

1

3

High-throughput

0.536

High

431947

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.536

High

438255

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.536

High

906765

NCS1
Neuronal calcium sensor 1

1

12

High-throughput

0.536

High

946253

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.536

High

957852

EFNB1
Ephrin-B1

1

2

High-throughput

0.536

High

1082818

CDC37
Hsp90 co-chaperone Cdc37

1

4

High-throughput

0.536

High

1136468

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

4

High-throughput

0.536

High

1136474

TCPQM
T-complex protein 1 subunit theta-like 2

1

5

High-throughput

0.536

High

1136475

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.536

High

1136480

CHODL
Chondrolectin

1

1

High-throughput

0.536

High

1136497

TACC3
Transforming acidic coiled-coil-containing protein 3

1

2

High-throughput

0.536

High

1136498

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

986682

EXOS9
Exosome complex component RRP45

1

0

High-throughput

0.513

High

451466

CLCA
Clathrin light chain A

1

5

High-throughput

0.489

High

451688

CLCB
Clathrin light chain B

1

4

High-throughput

0.489

High

517299

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.489

High

901307

NCALD
Neurocalcin-delta

1

12

High-throughput

0.489

High

1057052

EPN4
Clathrin interactor 1

1

1

High-throughput

0.489

High

1136463

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.489

High

151030

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

10

High-throughput

0.479

High

196452

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

2

High-throughput

0.479

High

216935

KIF1C
Kinesin-like protein KIF1C

1

7

High-throughput

0.479

High

350236

RASK
GTPase KRas

1

6

High-throughput

0.479

High

598483

NF1
Neurofibromin

1

4

High-throughput

0.479

High

673485

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

673590

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

749579

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

880753

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

915740

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

1060542

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

1136458

SYDE1
Rho GTPase-activating protein SYDE1

1

9

High-throughput

0.479

High

1136472

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

7

High-throughput

0.479

High

1136481

KI13B
Kinesin-like protein KIF13B

1

7

High-throughput

0.479

High

1136489

NGAP
Ras GTPase-activating protein nGAP

1

4

High-throughput

0.479

High

1136490

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.479

High

1136492

PPM1H
Protein phosphatase 1H

1

5

High-throughput

0.479

High

237229

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

316254

NADK
NAD kinase

1

0

High-throughput

0.458

High

940451

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1136467

SRS12
Serine/arginine-rich splicing factor 12

1

0

High-throughput

0.458

High

1136476

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.458

High

1136495

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

264321

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

318158

DIRA3
GTP-binding protein Di-Ras3

1

2

High-throughput

0.437

High

527512

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.437

High

892422

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.437

High

997166

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

5

High-throughput

0.437

High

1070236

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.437

High

1136453

DEN4C
DENN domain-containing protein 4C

1

4

High-throughput

0.437

High

1136455

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1136457

GGYF2
GRB10-interacting GYF protein 2

1

10

High-throughput

0.437

High

1136459

ATG9A
Autophagy-related protein 9A

1

2

High-throughput

0.437

High

1136464

F110B
Protein FAM110B

1

2

High-throughput

0.437

High

1136466

DEN1A
DENN domain-containing protein 1A

1

5

High-throughput

0.437

High

1136469

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1136470

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.437

High

1136478

F110A
Protein FAM110A

1

2

High-throughput

0.437

High

1136482

I17RB
Interleukin-17 receptor B

1

1

Small-scale

0.437

High

1136483

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

6

High-throughput

0.437

High

1136487

CING
Cingulin

1

6

High-throughput

0.437

High

1136488

LIMA1
LIM domain and actin-binding protein 1

1

6

High-throughput

0.437

High

1136491

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.437

High

353946

IGHM
Immunoglobulin heavy constant mu

1

2

High-throughput

0.407

High

1136465

HAVR2
Hepatitis A virus cellular receptor 2

2

0

High-throughput

0.328

High

179193

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

1136471

OPALI
Opalin

1

0

High-throughput

0.279

Low

559753

H12
Histone H1.2

1

0

High-throughput

0.269

Low

178584

STX7
Syntaxin-7

1

0

High-throughput

0.249

Low

914122

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

1136485

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

1136496

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024