Protein: SHCAF
SIN3-HDAC complex-associated factor (Protein FAM60A) (Tera protein homolog)

Gene: SHCAF, SINHCAF
Organism: Homo sapiens
Interactions: 131
UniProt ID: Q9NP50

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0008284 - positive regulation of cell population proliferation
GO:0030336 - negative regulation of cell migration
GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1038734

HDAC1
Histone deacetylase 1

6

1

Small-scale

0.740

High

1083399

RBBP7
Histone-binding protein RBBP7

5

1

Small-scale

0.718

High

265266

SAP30
Histone deacetylase complex subunit SAP30

4

1

Small-scale

0.699

High

997916

RBBP4
Histone-binding protein RBBP4

4

1

Small-scale

0.699

High

1270458

HDAC2
Histone deacetylase 2

4

1

Small-scale

0.699

High

257837

SIN3B
Paired amphipathic helix protein Sin3b

3

1

Small-scale

0.667

High

666510

ARI4A
AT-rich interactive domain-containing protein 4A

3

1

Small-scale

0.667

High

1117705

ARI4B
AT-rich interactive domain-containing protein 4B

3

1

Small-scale

0.667

High

1129660

BRM1L
Breast cancer metastasis-suppressor 1-like protein

3

2

Small-scale

0.667

High

1302453

SIN3A
Paired amphipathic helix protein Sin3a

3

1

Small-scale

0.667

High

1327626

SP130
Histone deacetylase complex subunit SAP130

3

2

Small-scale

0.667

High

1328468

ING2
Inhibitor of growth protein 2

3

3

Small-scale

0.667

High

1333157

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

3

2

Small-scale

0.667

High

1334748

SP30L
Histone deacetylase complex subunit SAP30L

3

1

Small-scale

0.667

High

1336541

BRMS1
Breast cancer metastasis-suppressor 1

3

2

Small-scale

0.667

High

1342266

ING1
Inhibitor of growth protein 1

3

3

Small-scale

0.667

High

344339

AACT
Alpha-1-antichymotrypsin

2

2

High-throughput

0.628

High

416516

S10A9
Protein S100-A9

2

2

High-throughput

0.628

High

678508

S10A7
Protein S100-A7

2

2

High-throughput

0.628

High

952881

FOXK1
Forkhead box protein K1

2

1

High-throughput

0.628

High

964265

FOXK2
Forkhead box protein K2

2

1

High-throughput

0.628

High

1087419

H2B2E
Histone H2B type 2-E

2

1

Small-scale

0.611

High

179065

TNC18
Trinucleotide repeat-containing gene 18 protein

3

2

Small-scale

0.609

High

1342262

BAHC1
BAH and coiled-coil domain-containing protein 1

3

2

Small-scale

0.609

High

322029

ZMYM6
Zinc finger MYM-type protein 6

2

0

High-throughput

0.602

High

884598

RAB25
Ras-related protein Rab-25

2

0

High-throughput

0.602

High

1033976

XRCC4
DNA repair protein XRCC4

2

0

High-throughput

0.602

High

1267709

NDRG1
Protein NDRG1

2

0

High-throughput

0.602

High

1312494

DHRS4
Dehydrogenase/reductase SDR family member 4

2

0

High-throughput

0.602

High

1237981

ZFP41
Zinc finger protein 41 homolog

2

0

High-throughput

0.580

High

428637

INVO
Involucrin

2

1

High-throughput

0.574

High

820392

SPB4
Serpin B4

2

2

High-throughput

0.574

High

945743

NGAL
Neutrophil gelatinase-associated lipocalin

2

1

High-throughput

0.574

High

1342261

CALL5
Calmodulin-like protein 5

2

1

High-throughput

0.574

High

917970

H4
Histone H4

2

0

Small-scale

0.559

High

668040

SPB3
Serpin B3

1

2

High-throughput

0.536

High

1282760

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

1

0

High-throughput

0.518

High

1050801

FHL2
Four and a half LIM domains protein 2

1

0

High-throughput

0.513

High

1216214

TF2LX
Homeobox protein TGIF2LX

1

0

High-throughput

0.513

High

396422

APOD
Apolipoprotein D

1

1

High-throughput

0.489

High

661451

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1067296

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

1

1

High-throughput

0.489

High

1030692

NMI
N-myc-interactor

1

0

High-throughput

0.486

High

211973

TLX3
T-cell leukemia homeobox protein 3

1

5

High-throughput

0.479

High

233897

HBP1
HMG box-containing protein 1

1

1

High-throughput

0.479

High

283039

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

1

Small-scale

0.479

High

347959

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

377707

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

379897

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

397520

ADT2
ADP/ATP translocase 2

1

2

Small-scale

0.479

High

516703

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

518496

ADT3
ADP/ATP translocase 3

1

2

Small-scale

0.479

High

582509

NUCL
Nucleolin

1

1

Small-scale

0.479

High

620209

PAX7
Paired box protein Pax-7

1

1

High-throughput

0.479

High

641569

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.479

High

679176

TLX1
T-cell leukemia homeobox protein 1

1

3

High-throughput

0.479

High

727593

HNF1B
Hepatocyte nuclear factor 1-beta

1

2

High-throughput

0.479

High

801400

KI67
Proliferation marker protein Ki-67

1

1

Small-scale

0.479

High

884251

KLF3
Krueppel-like factor 3

1

3

High-throughput

0.479

High

927557

1433Z
14-3-3 protein zeta/delta

1

1

Small-scale

0.479

High

966776

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

Small-scale

0.479

High

967981

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1024882

KLF10
Krueppel-like factor 10

1

2

High-throughput

0.479

High

1046667

KLF9
Krueppel-like factor 9

1

3

High-throughput

0.479

High

1056995

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

Small-scale

0.479

High

1077606

ELF2
ETS-related transcription factor Elf-2

1

1

High-throughput

0.479

High

1192225

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

Small-scale

0.479

High

1254930

SP7
Transcription factor Sp7

1

3

High-throughput

0.479

High

1300952

CIC
Protein capicua homolog

1

1

High-throughput

0.479

High

1304899

ELF4
ETS-related transcription factor Elf-4

1

1

High-throughput

0.479

High

1307142

H2B1L
Histone H2B type 1-L

1

1

Small-scale

0.479

High

1315363

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.479

High

1334422

NANOG
Homeobox protein NANOG

1

3

High-throughput

0.479

High

1342260

VSX1
Visual system homeobox 1

1

3

High-throughput

0.479

High

171083

TBXT
T-box transcription factor T

1

0

High-throughput

0.458

High

264238

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.458

High

509135

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.458

High

546046

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.458

High

620428

GATA2
Endothelial transcription factor GATA-2

1

0

High-throughput

0.458

High

632922

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

653384

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.458

High

709066

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.458

High

782663

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.458

High

839828

LHX2
LIM/homeobox protein Lhx2

1

0

High-throughput

0.458

High

850201

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

Small-scale

0.458

High

892050

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.458

High

910053

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.458

High

931882

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

944445

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

985258

HME1
Homeobox protein engrailed-1

1

0

High-throughput

0.458

High

994347

DHX9
ATP-dependent RNA helicase A

1

0

Small-scale

0.458

High

1060371

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.458

High

1260547

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1281403

FBXW7
F-box/WD repeat-containing protein 7

1

0

Small-scale

0.458

High

1296214

H2A1H
Histone H2A type 1-H

1

0

Small-scale

0.458

High

1302996

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

Small-scale

0.458

High

1304121

RING2
E3 ubiquitin-protein ligase RING2

1

0

High-throughput

0.458

High

1342259

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

0

Small-scale

0.458

High

1342265

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1342267

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

Small-scale

0.458

High

393361

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.437

High

518207

ADT1
ADP/ATP translocase 1

1

2

Small-scale

0.437

High

561690

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

Small-scale

0.437

High

571778

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

1

Small-scale

0.437

High

637069

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

1342263

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

572148

SAP3
Ganglioside GM2 activator

2

0

High-throughput

0.328

High

588452

TYPH
Thymidine phosphorylase

2

0

High-throughput

0.328

High

648612

CALL3
Calmodulin-like protein 3

2

0

High-throughput

0.328

High

832942

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.328

High

1079063

CYTM
Cystatin-M

2

0

High-throughput

0.328

High

1342268

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

2

0

High-throughput

0.328

High

434435

TPM2
Tropomyosin beta chain

1

0

High-throughput

0.279

Low

1028284

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1251542

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.251

Low

151916

IRS4
Insulin receptor substrate 4

1

0

Small-scale

0.249

Low

208007

XPOT
Exportin-T

1

0

Small-scale

0.249

Low

299989

ERLN2
Erlin-2

1

0

Small-scale

0.249

Low

443829

VIME
Vimentin

1

0

Small-scale

0.249

Low

827608

EFTU
Elongation factor Tu, mitochondrial

1

0

Small-scale

0.249

Low

839156

EMD
Emerin

1

0

Small-scale

0.249

Low

863339

COPB
Coatomer subunit beta

1

0

Small-scale

0.249

Low

950562

ARF1
ADP-ribosylation factor 1

1

0

Small-scale

0.249

Low

995235

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.249

Low

1051684

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

Small-scale

0.249

Low

1114367

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.249

Low

1268257

GCN1
Stalled ribosome sensor GCN1

1

0

Small-scale

0.249

Low

1331356

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1342258

DDX21
Nucleolar RNA helicase 2

1

0

Small-scale

0.249

Low

1342264

KS6B2
Ribosomal protein S6 kinase beta-2

1

0

High-throughput

0.249

Low

353562

IGKC
Immunoglobulin kappa constant

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024