Protein: TOPB1
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)

Gene: TOPB1, TOPBP1
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q92547

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000077 - DNA damage checkpoint signaling
GO:0000724 - double-strand break repair via homologous recombination
GO:0000794 - condensed nuclear chromosome
GO:0000922 - spindle pole

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

749723

BRCA1
Breast cancer type 1 susceptibility protein

8

13

Small-scale

0.953

High

1056907

MDC1
Mediator of DNA damage checkpoint protein 1

6

14

Small-scale

0.949

High

1266872

TOPB1
DNA topoisomerase 2-binding protein 1

2

11

Small-scale

0.825

High

455712

PARP1
Poly [ADP-ribose] polymerase 1

2

14

Small-scale

0.806

High

1266876

RAD9A
Cell cycle checkpoint control protein RAD9A

13

1

Small-scale

0.759

High

963655

E2F1
Transcription factor E2F1

7

4

Small-scale

0.755

High

246253

NBN
Nibrin

2

3

Small-scale

0.754

High

1187995

TICRR
Treslin

6

14

Small-scale

0.735

High

1266880

FANCJ
Fanconi anemia group J protein

7

0

Small-scale

0.714

High

1038145

ATR
Serine/threonine-protein kinase ATR

5

14

Small-scale

0.713

High

387207

P53
Cellular tumor antigen p53

5

6

Small-scale

0.702

High

861866

PLK1
Serine/threonine-protein kinase PLK1

4

6

Small-scale

0.694

High

1266878

BARD1
BRCA1-associated RING domain protein 1

1

7

Small-scale

0.691

High

1222488

SLX4
Structure-specific endonuclease subunit SLX4

4

15

Small-scale

0.676

High

1266879

RHNO1
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

4

0

Small-scale

0.670

High

264225

CDC45
Cell division control protein 45 homolog

3

1

Small-scale

0.670

High

1263396

ATRIP
ATR-interacting protein

3

1

Small-scale

0.646

High

1024293

ZBT17
Zinc finger and BTB domain-containing protein 17

3

0

Small-scale

0.645

High

370109

ESR1
Estrogen receptor

3

12

Small-scale

0.641

High

1266896

PHF8
Histone lysine demethylase PHF8

2

1

Small-scale

0.639

High

867622

BLM
RecQ-like DNA helicase BLM

2

9

Small-scale

0.629

High

1266892

MUTYH
Adenine DNA glycosylase

2

2

Small-scale

0.624

High

1243259

MCPH1
Microcephalin

1

1

Small-scale

0.618

High

1266890

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

4

High-throughput

0.618

High

681953

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.608

High

1031574

ATM
Serine-protein kinase ATM

2

14

Small-scale

0.595

High

1266891

TCF20
Transcription factor 20

1

13

Small-scale

0.594

High

668861

PML
Protein PML

2

5

Small-scale

0.584

High

917671

H4
Histone H4

2

7

Small-scale

0.584

High

1019043

TP53B
TP53-binding protein 1

2

13

Small-scale

0.584

High

337516

ABL1
Tyrosine-protein kinase ABL1

1

2

Small-scale

0.578

High

304268

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.573

High

245908

HUS1
Checkpoint protein HUS1

1

1

Small-scale

0.561

High

1266873

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

4

Small-scale

0.561

High

1253520

CIP2A
Protein CIP2A

2

0

Small-scale

0.559

High

238278

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.537

High

617763

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.537

High

1266885

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1266883

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

7

Small-scale

0.527

High

559866

H12
Histone H1.2

1

5

High-throughput

0.515

High

992295

DPOE1
DNA polymerase epsilon catalytic subunit A

1

5

Small-scale

0.515

High

1069452

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

737950

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

Small-scale

0.508

High

154223

CHK1
Serine/threonine-protein kinase Chk1

1

2

Small-scale

0.501

High

973373

TOP2B
DNA topoisomerase 2-beta

1

4

Small-scale

0.481

High

1034354

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.481

High

1044667

FHL3
Four and a half LIM domains protein 3

1

5

High-throughput

0.481

High

1058088

PSF1
DNA replication complex GINS protein PSF1

1

1

Small-scale

0.481

High

1191017

RAI1
Retinoic acid-induced protein 1

1

15

Small-scale

0.481

High

1243726

PPHLN
Periphilin-1

1

1

Small-scale

0.481

High

1266877

CTIP
DNA endonuclease RBBP8

1

1

High-throughput

0.481

High

175898

P73
Tumor protein p73

1

6

Small-scale

0.479

High

179750

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

8

High-throughput

0.479

High

203749

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.479

High

278311

PIAS2
E3 SUMO-protein ligase PIAS2

1

5

Small-scale

0.479

High

476129

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

Small-scale

0.479

High

502382

BIP
Endoplasmic reticulum chaperone BiP

1

3

Small-scale

0.479

High

504487

HSP7C
Heat shock cognate 71 kDa protein

1

1

Small-scale

0.479

High

508636

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.479

High

553312

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

651820

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

652939

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

721040

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

826319

CDK8
Cyclin-dependent kinase 8

1

6

Small-scale

0.479

High

847034

SMCA4
Transcription activator BRG1

1

6

Small-scale

0.479

High

855519

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.479

High

918565

H2B1C
Histone H2B type 1-C/E/F/G/I

1

9

High-throughput

0.479

High

929949

ACTG
Actin, cytoplasmic 2

1

4

Small-scale

0.479

High

935052

H31
Histone H3.1

1

8

High-throughput

0.479

High

952508

H33
Histone H3.3

1

8

High-throughput

0.479

High

963867

SET
Protein SET

1

1

Small-scale

0.479

High

966269

TFAP4
Transcription factor AP-4

1

1

Small-scale

0.479

High

1027155

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1082303

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

1188636

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1221338

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

1

High-throughput

0.479

High

1221609

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

1244405

NUP43
Nucleoporin Nup43

1

16

High-throughput

0.479

High

1266875

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.479

High

1266881

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1266882

P63
Tumor protein 63

1

6

Small-scale

0.479

High

1266884

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1266887

SMC4
Structural maintenance of chromosomes protein 4

1

5

Small-scale

0.479

High

1266889

NLE1
Notchless protein homolog 1

1

6

High-throughput

0.479

High

1266893

PSME2
Proteasome activator complex subunit 2

1

1

High-throughput

0.479

High

1266897

ZN330
Zinc finger protein 330

1

1

High-throughput

0.479

High

1266898

DCAF1
DDB1- and CUL4-associated factor 1

1

11

Small-scale

0.479

High

1223114

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.460

High

869879

PMS2
Mismatch repair endonuclease PMS2

1

0

Small-scale

0.458

High

1120005

PDCD4
Programmed cell death protein 4

1

0

High-throughput

0.458

High

1255924

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

Small-scale

0.458

High

1266886

RMI1
RecQ-mediated genome instability protein 1

1

0

Small-scale

0.458

High

1266899

TELO2
Telomere length regulation protein TEL2 homolog

1

0

Small-scale

0.458

High

152673

KMT2D
Histone-lysine N-methyltransferase 2D

1

15

Small-scale

0.457

High

302418

CSTN1
Calsyntenin-1

1

2

Small-scale

0.457

High

975295

KMT2A
Histone-lysine N-methyltransferase 2A

1

14

Small-scale

0.457

High

1266895

KMT2B
Histone-lysine N-methyltransferase 2B

1

12

Small-scale

0.457

High

321146

PTBP3
Polypyrimidine tract-binding protein 3

1

6

High-throughput

0.445

High

1266894

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

232699

TBCD4
TBC1 domain family member 4

1

2

Small-scale

0.417

High

1088450

CDO1
Cysteine dioxygenase type 1

2

0

High-throughput

0.328

High

1266888

CBLN4
Cerebellin-4

2

0

High-throughput

0.328

High

1266874

MTBP
Mdm2-binding protein

2

0

Small-scale

0.305

High

1185431

OTU6A
OTU domain-containing protein 6A

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024