Protein: PTN3
Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)

Gene: PTN3, PTPN3
Organism: Homo sapiens
Interactions: 100
UniProt ID: P26045

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001784 - phosphotyrosine residue binding
GO:0004725 - protein tyrosine phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

500947

GHR
Growth hormone receptor

1

16

Small-scale

0.785

High

640216

1433B
14-3-3 protein beta/alpha

9

20

Small-scale

0.756

High

640228

1433G
14-3-3 protein gamma

9

20

High-throughput

0.755

High

640212

1433T
14-3-3 protein theta

8

20

High-throughput

0.752

High

640230

1433Z
14-3-3 protein zeta/delta

8

20

High-throughput

0.751

High

640237

1433F
14-3-3 protein eta

7

20

High-throughput

0.748

High

640229

1433E
14-3-3 protein epsilon

5

8

High-throughput

0.720

High

640260

VANG1
Vang-like protein 1

4

10

High-throughput

0.699

High

640292

KCTD3
BTB/POZ domain-containing protein KCTD3

4

5

High-throughput

0.697

High

640277

WDR6
tRNA

3

7

High-throughput

0.675

High

411302

INSR
Insulin receptor

1

20

Small-scale

0.666

High

640224

MK12
Mitogen-activated protein kinase 12

2

12

Small-scale

0.648

High

383622

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

441435

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.647

High

640236

AK1C1
Aldo-keto reductase family 1 member C1

3

0

High-throughput

0.646

High

640289

SCML1
Sex comb on midleg-like protein 1

1

3

High-throughput

0.640

High

640261

SHKB1
SH3KBP1-binding protein 1

4

9

High-throughput

0.636

High

640250

AAAT
Neutral amino acid transporter B(0)

3

0

High-throughput

0.628

High

617433

CRCM
Colorectal mutant cancer protein

2

4

High-throughput

0.621

High

640288

VANG2
Vang-like protein 2

2

10

High-throughput

0.621

High

349136

RASH
GTPase HRas

1

20

High-throughput

0.618

High

640211

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

15

High-throughput

0.618

High

640239

ZO1
Tight junction protein ZO-1

1

20

High-throughput

0.618

High

640276

E41L5
Band 4.1-like protein 5

1

14

High-throughput

0.618

High

640285

ZO2
Tight junction protein ZO-2

1

20

High-throughput

0.618

High

638478

RBTN1
Rhombotin-1

3

8

High-throughput

0.616

High

640226

TERA
Transitional endoplasmic reticulum ATPase

2

3

Small-scale

0.611

High

640219

EPS15
Epidermal growth factor receptor substrate 15

1

10

Small-scale

0.608

High

640263

TRI41
E3 ubiquitin-protein ligase TRIM41

2

3

High-throughput

0.606

High

153216

ACOT8
Acyl-coenzyme A thioesterase 8

2

0

High-throughput

0.585

High

640275

CYBP
Calcyclin-binding protein

2

2

High-throughput

0.584

High

640267

MTMR9
Myotubularin-related protein 9

2

0

High-throughput

0.580

High

640290

SRRM2
Serine/arginine repetitive matrix protein 2

2

13

High-throughput

0.580

High

640272

KPCD2
Serine/threonine-protein kinase D2

2

6

High-throughput

0.576

High

445153

IBP1
Insulin-like growth factor-binding protein 1

2

2

High-throughput

0.574

High

640247

DIP2A
Disco-interacting protein 2 homolog A

1

1

High-throughput

0.573

High

640278

NXT2
NTF2-related export protein 2

1

1

High-throughput

0.573

High

640249

KS6A1
Ribosomal protein S6 kinase alpha-1

2

9

Small-scale

0.563

High

640227

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

High-throughput

0.554

High

640241

ILF2
Interleukin enhancer-binding factor 2

1

1

High-throughput

0.554

High

640242

ILF3
Interleukin enhancer-binding factor 3

1

6

High-throughput

0.554

High

640244

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

6

High-throughput

0.554

High

640218

MLH1
DNA mismatch repair protein Mlh1

2

2

High-throughput

0.553

High

640251

VWA2
von Willebrand factor A domain-containing protein 2

2

3

High-throughput

0.553

High

640274

PKHF2
Pleckstrin homology domain-containing family F member 2

2

4

High-throughput

0.553

High

640246

SCN5A
Sodium channel protein type 5 subunit alpha

1

10

Small-scale

0.552

High

388236

HSPB1
Heat shock protein beta-1

1

7

High-throughput

0.541

High

640215

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

High-throughput

0.541

High

640213

CD6
T-cell differentiation antigen CD6

1

5

High-throughput

0.536

High

640231

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.536

High

509905

VDR
Vitamin D3 receptor

1

7

Small-scale

0.534

High

640283

HTR5B
HEAT repeat-containing protein 5B

1

0

High-throughput

0.530

High

640271

ACE2
Angiotensin-converting enzyme 2

1

3

Small-scale

0.527

High

640262

ZCH10
Zinc finger CCHC domain-containing protein 10

1

6

High-throughput

0.523

High

640217

1433S
14-3-3 protein sigma

1

20

High-throughput

0.515

High

640232

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

4

Small-scale

0.506

High

640254

RN111
E3 ubiquitin-protein ligase Arkadia

1

9

High-throughput

0.481

High

216445

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.479

High

327227

DLGP3
Disks large-associated protein 3

1

2

High-throughput

0.479

High

444078

RS17
Small ribosomal subunit protein eS17

1

1

High-throughput

0.479

High

506517

BCR
Breakpoint cluster region protein

1

12

High-throughput

0.479

High

588540

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

7

High-throughput

0.479

High

640220

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

640221

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.479

High

640223

KS6A3
Ribosomal protein S6 kinase alpha-3

1

5

High-throughput

0.479

High

640225

ICLN
Methylosome subunit pICln

1

6

High-throughput

0.479

High

640238

UBE3A
Ubiquitin-protein ligase E3A

1

10

Small-scale

0.479

High

640243

DGKZ
Diacylglycerol kinase zeta

1

4

High-throughput

0.479

High

640245

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

High-throughput

0.479

High

640252

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

20

High-throughput

0.479

High

640256

MAPK5
MAP kinase-activated protein kinase 5

1

3

High-throughput

0.479

High

640257

ARL14
ADP-ribosylation factor-like protein 14

1

17

High-throughput

0.479

High

640268

KIF2C
Kinesin-like protein KIF2C

1

10

High-throughput

0.479

High

640269

LZTS2
Leucine zipper putative tumor suppressor 2

1

10

High-throughput

0.479

High

640273

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

640279

ANLN
Anillin

1

7

High-throughput

0.479

High

640282

DTL
Denticleless protein homolog

1

4

High-throughput

0.479

High

640284

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.479

High

640286

KDIS
Kinase D-interacting substrate of 220 kDa

1

10

High-throughput

0.479

High

640255

SRCAP
Helicase SRCAP

1

5

High-throughput

0.470

High

311365

6PGL
6-phosphogluconolactonase

1

0

High-throughput

0.458

High

640222

AL9A1
4-trimethylaminobutyraldehyde dehydrogenase

1

0

High-throughput

0.458

High

640264

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

640265

PTCD3
Small ribosomal subunit protein mS39

1

0

High-throughput

0.458

High

640240

KIF1A
Kinesin-like protein KIF1A

1

9

High-throughput

0.437

High

640248

Q149M6
Exophilin 5

1

1

High-throughput

0.437

High

640253

MYORG
Myogenesis-regulating glycosidase

1

1

High-throughput

0.437

High

640280

WDR70
WD repeat-containing protein 70

1

5

High-throughput

0.437

High

640281

ASND1
Asparagine synthetase domain-containing protein 1

1

1

High-throughput

0.437

High

640287

ANR50
Ankyrin repeat domain-containing protein 50

1

9

High-throughput

0.437

High

640266

Z512B
Zinc finger protein 512B

1

5

High-throughput

0.417

High

640259

EXPH5
Exophilin-5

1

1

High-throughput

0.407

High

640235

TFAP4
Transcription factor AP-4

2

0

High-throughput

0.316

High

640258

TET5D
Terminal nucleotidyltransferase 5D

2

0

High-throughput

0.316

High

640214

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.289

High

640233

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.249

Low

640234

RT35
Small ribosomal subunit protein mS35

1

0

High-throughput

0.249

Low

640270

SEN34
tRNA-splicing endonuclease subunit Sen34

1

0

High-throughput

0.249

Low

640291

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024