Protein: SAP
Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]

Gene: SAP, PSAP
Organism: Homo sapiens
Interactions: 59
UniProt ID: P07602

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005543 - phospholipid binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

429290

SAP
Prosaposin

2

1

Small-scale

0.790

High

429298

GRN
Progranulin

2

2

High-throughput

0.633

High

429333

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

429312

PAK1
Serine/threonine-protein kinase PAK 1

2

0

High-throughput

0.547

High

383536

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.541

High

429304

HSP13
Heat shock 70 kDa protein 13

1

3

High-throughput

0.541

High

429314

SGCG
Gamma-sarcoglycan

1

0

High-throughput

0.518

High

429331

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

0

High-throughput

0.518

High

429292

CATB
Cathepsin B

1

2

High-throughput

0.515

High

393942

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

429305

KC1D
Casein kinase I isoform delta

1

3

High-throughput

0.515

High

336311

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

429295

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

429297

CALX
Calnexin

1

0

High-throughput

0.513

High

429317

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.513

High

429328

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

429300

TRY3
Trypsin-3

1

1

Small-scale

0.501

High

429306

KLK7
Kallikrein-7

1

1

Small-scale

0.501

High

429316

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.494

High

429293

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.493

High

429310

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.486

High

429332

NLGN3
Neuroligin-3

1

0

Small-scale

0.486

High

429302

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.481

High

225474

PCDH7
Protocadherin-7

1

1

High-throughput

0.479

High

344921

CYTN
Cystatin-SN

1

1

Small-scale

0.479

High

373538

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

427028

CATD
Cathepsin D

1

3

Small-scale

0.479

High

429294

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

429308

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.479

High

171358

SMAD9
Mothers against decapentaplegic homolog 9

1

1

High-throughput

0.464

High

429318

SMAD2
Mothers against decapentaplegic homolog 2

1

1

High-throughput

0.464

High

429311

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

Small-scale

0.460

High

155243

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

204938

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

305844

UBL3
Ubiquitin-like protein 3

1

0

Small-scale

0.458

High

429291

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

429296

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

429301

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

429315

CUL3
Cullin-3

1

0

High-throughput

0.458

High

429325

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

429319

HSPB2
Heat shock protein beta-2

1

2

High-throughput

0.457

High

429320

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

429323

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.437

High

429313

STF1
Steroidogenic factor 1

1

0

Small-scale

0.426

High

330540

ZBED1
E3 SUMO-protein ligase ZBED1

3

0

High-throughput

0.348

High

429307

PEX5
Peroxisomal targeting signal 1 receptor

2

0

High-throughput

0.316

High

429327

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.316

High

429329

FBX6
F-box only protein 6

2

0

High-throughput

0.305

High

429321

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.282

High

429324

PRAG1
Inactive tyrosine-protein kinase PRAG1

1

0

High-throughput

0.282

High

429334

MAFF
Transcription factor MafF

1

0

High-throughput

0.282

High

429322

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

0

Small-scale

0.251

Low

345713

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

429299

CASPE
Caspase-14

1

0

Small-scale

0.249

Low

429303

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

429309

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.249

Low

429326

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.249

Low

429330

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024