Protein: UBR1
E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-recognin-1) (RING-type E3 ubiquitin transferase UBR1) (Ubiquitin-protein ligase E3-alpha-1) (Ubiquitin-protein ligase E3-alpha-I)

Gene: UBR1
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q8IWV7

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000502 - proteasome complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

351413

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

4

3

High-throughput

0.694

High

927762

UBE2B
Ubiquitin-conjugating enzyme E2 B

4

14

Small-scale

0.692

High

995895

DEMA
Dematin

3

0

High-throughput

0.638

High

1219616

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

3

0

High-throughput

0.638

High

155396

NRP1
Neuropilin-1

2

1

High-throughput

0.628

High

443638

VIME
Vimentin

2

4

High-throughput

0.628

High

535459

GFAP
Glial fibrillary acidic protein

2

4

High-throughput

0.628

High

821784

NEST
Nestin

2

6

High-throughput

0.628

High

170551

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

2

High-throughput

0.609

High

305223

NXPH2
Neurexophilin-2

3

1

High-throughput

0.609

High

534257

YJU2B
Probable splicing factor YJU2B

3

1

High-throughput

0.609

High

574222

BMP7
Bone morphogenetic protein 7

3

3

High-throughput

0.609

High

885651

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

3

2

High-throughput

0.609

High

1152886

MRM1
rRNA methyltransferase 1, mitochondrial

3

1

High-throughput

0.609

High

1191284

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.602

High

1202897

SPA24
Spermatogenesis-associated protein 24

2

0

High-throughput

0.602

High

1219586

PDIP3
Polymerase delta-interacting protein 3

2

0

High-throughput

0.602

High

1219613

RABX5
Rab5 GDP/GTP exchange factor

2

0

High-throughput

0.602

High

829027

UBE2A
Ubiquitin-conjugating enzyme E2 A

2

14

Small-scale

0.600

High

1219580

PLIN2
Perilipin-2

1

4

Small-scale

0.578

High

589716

ISK2
Serine protease inhibitor Kazal-type 2

2

1

High-throughput

0.574

High

622641

CRHBP
Corticotropin-releasing factor-binding protein

2

1

High-throughput

0.574

High

870024

LIPR1
Inactive pancreatic lipase-related protein 1

2

1

High-throughput

0.574

High

1219579

CLCC1
Chloride channel CLIC-like protein 1

2

1

High-throughput

0.574

High

1219589

PDGFD
Platelet-derived growth factor D

2

2

High-throughput

0.574

High

1219592

SIL1
Nucleotide exchange factor SIL1

2

1

High-throughput

0.574

High

1219619

INSL5
Insulin-like peptide INSL5

2

1

High-throughput

0.574

High

345484

FOS
Protein c-Fos

1

3

Small-scale

0.561

High

1032002

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

1

High-throughput

0.541

High

213967

KRT86
Keratin, type II cuticular Hb6

1

1

High-throughput

0.536

High

299414

UBXN7
UBX domain-containing protein 7

1

7

High-throughput

0.536

High

327852

CBX7
Chromobox protein homolog 7

1

1

High-throughput

0.536

High

886011

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

1

High-throughput

0.536

High

979323

UBXN1
UBX domain-containing protein 1

1

5

High-throughput

0.536

High

1055063

KT33B
Keratin, type I cuticular Ha3-II

1

3

High-throughput

0.536

High

1071258

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.536

High

1137089

CROCC
Rootletin

1

1

High-throughput

0.536

High

1219573

SPSB4
SPRY domain-containing SOCS box protein 4

1

3

High-throughput

0.536

High

1219603

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

1

High-throughput

0.536

High

1219614

FAF1
FAS-associated factor 1

1

7

High-throughput

0.536

High

365211

FRIH
Ferritin heavy chain

1

0

High-throughput

0.518

High

519686

ANXA3
Annexin A3

1

0

High-throughput

0.518

High

734522

ARL3
ADP-ribosylation factor-like protein 3

1

0

High-throughput

0.518

High

830765

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.518

High

839532

SPB9
Serpin B9

1

0

High-throughput

0.518

High

894197

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.518

High

1120569

QORX
Quinone oxidoreductase PIG3

1

0

High-throughput

0.518

High

1219585

BTBD2
BTB/POZ domain-containing protein 2

1

0

High-throughput

0.518

High

1191442

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

714673

CNR2
Cannabinoid receptor 2

1

0

Small-scale

0.513

High

893574

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.513

High

970716

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

0

High-throughput

0.513

High

1041390

CUL2
Cullin-2

1

0

High-throughput

0.513

High

1219566

ZN383
Zinc finger protein 383

1

0

High-throughput

0.513

High

1219571

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

1219574

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.513

High

1219583

FEM1A
Protein fem-1 homolog A

1

0

High-throughput

0.513

High

1219605

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

0

High-throughput

0.513

High

1219620

CBPQ
Carboxypeptidase Q

1

0

High-throughput

0.513

High

208165

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.508

High

835871

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.508

High

919779

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

11

High-throughput

0.501

High

1081780

LAMA4
Laminin subunit alpha-4

1

1

High-throughput

0.494

High

1219617

RASD1
Dexamethasone-induced Ras-related protein 1

1

0

High-throughput

0.493

High

352173

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.489

High

352358

IGF2
Insulin-like growth factor II

1

3

High-throughput

0.489

High

382611

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

2

High-throughput

0.489

High

474741

CFC1
Cryptic protein

1

3

High-throughput

0.489

High

526906

TDGF1
Protein Cripto

1

3

High-throughput

0.489

High

601644

SIAL
Integrin-binding sialoprotein

1

1

High-throughput

0.489

High

678840

HXA7
Homeobox protein Hox-A7

1

2

High-throughput

0.489

High

894877

SPCS3
Signal peptidase complex subunit 3

1

1

High-throughput

0.489

High

1086128

AMHR2
Anti-Muellerian hormone type-2 receptor

1

1

High-throughput

0.489

High

1144535

EGFLA
Pikachurin

1

1

High-throughput

0.489

High

1219501

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.489

High

1219569

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

1

High-throughput

0.489

High

1219570

G45IP
Large ribosomal subunit protein mL64

1

1

High-throughput

0.489

High

1219577

FAF2
FAS-associated factor 2

1

7

High-throughput

0.489

High

1219584

CRDL1
Chordin-like protein 1

1

3

High-throughput

0.489

High

1219588

CD244
Natural killer cell receptor 2B4

1

2

High-throughput

0.489

High

1219590

WN10A
Protein Wnt-10a

1

2

High-throughput

0.489

High

1219594

IL25
Interleukin-25

1

1

High-throughput

0.489

High

1219599

CBX8
Chromobox protein homolog 8

1

1

High-throughput

0.489

High

1219610

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.489

High

1219611

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.489

High

329115

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

622958

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.486

High

992099

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.486

High

377468

GCR
Glucocorticoid receptor

1

1

Small-scale

0.481

High

878135

PKNX1
Homeobox protein PKNOX1

1

1

Small-scale

0.481

High

1219575

NTAN1
Protein N-terminal asparagine amidohydrolase

1

1

Small-scale

0.481

High

1219578

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

1

Small-scale

0.481

High

1219581

CDC6
Cell division control protein 6 homolog

1

0

Small-scale

0.480

High

295003

RECQ4
ATP-dependent DNA helicase Q4

1

1

Small-scale

0.479

High

347261

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

453459

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

476022

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.479

High

749656

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

1170713

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1219598

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

8

Small-scale

0.479

High

1219607

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1219612

HERC5
E3 ISG15--protein ligase HERC5

1

1

Small-scale

0.479

High

1219615

NSF1C
NSFL1 cofactor p47

1

1

High-throughput

0.479

High

1219587

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

1219601

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

849365

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

11

Small-scale

0.445

High

579216

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

3

Small-scale

0.439

High

1161011

SG11A
Sperm-associated antigen 11A

1

1

High-throughput

0.437

High

1219595

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.437

High

834941

RGS4
Regulator of G-protein signaling 4

1

1

Small-scale

0.408

High

996165

SG11B
Sperm-associated antigen 11B

1

1

High-throughput

0.407

High

996493

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

1219565

SCML4
Sex comb on midleg-like protein 4

3

0

High-throughput

0.347

High

1219618

ITM2B
Integral membrane protein 2B

3

0

High-throughput

0.347

High

304547

PRS23
Serine protease 23

2

0

High-throughput

0.328

High

1219568

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

1219593

EPN3
Epsin-3

2

0

High-throughput

0.328

High

420647

CRF
Corticoliberin

2

0

High-throughput

0.324

High

1219606

DJB11
DnaJ homolog subfamily B member 11

2

0

High-throughput

0.323

High

1219602

NUA4L
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2

1

0

High-throughput

0.282

High

1219604

ARL15
ADP-ribosylation factor-like protein 15

1

0

High-throughput

0.282

High

1219609

TKNK
Tachykinin-3

1

0

High-throughput

0.282

High

499211

PF4V
Platelet factor 4 variant

1

0

High-throughput

0.279

Low

611577

GNLY
Granulysin

1

0

High-throughput

0.279

Low

622251

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.279

Low

793785

CATO
Cathepsin O

1

0

High-throughput

0.279

Low

1131308

LY65C
Lymphocyte antigen 6 complex locus protein G5c

1

0

High-throughput

0.279

Low

1191645

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

1203368

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

1219567

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

1219572

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.279

Low

1219576

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.279

Low

1219582

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.279

Low

1219591

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.279

Low

1219596

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.279

Low

1219597

GREM2
Gremlin-2

1

0

High-throughput

0.279

Low

363621

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

429531

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.268

Low

1219608

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.265

Low

385132

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

509874

PSG1
Pregnancy-specific beta-1-glycoprotein 1

1

0

High-throughput

0.249

Low

553128

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

1219600

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.249

Low

199231

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024