Protein: TAL1
T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)

Gene: TAL1
Organism: Homo sapiens
Interactions: 95
UniProt ID: P17542

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551464

TFE2
Transcription factor E2-alpha

9

20

Small-scale

0.976

High

568226

HTF4
Transcription factor 12

7

20

Small-scale

0.963

High

551060

ITF2
Transcription factor 4

6

20

Small-scale

0.944

High

568179

RBTN2
Rhombotin-2

5

17

Small-scale

0.935

High

568180

RBTN1
Rhombotin-1

2

17

Small-scale

0.807

High

568188

ID4
DNA-binding protein inhibitor ID-4

2

19

High-throughput

0.798

High

568217

LDB1
LIM domain-binding protein 1

4

4

Small-scale

0.699

High

524533

LYL1
Protein lyl-1

1

19

Small-scale

0.691

High

253966

MTG16
Protein CBFA2T3

3

11

Small-scale

0.678

High

568206

EP300
Histone acetyltransferase p300

3

16

Small-scale

0.676

High

568199

SSBP2
Single-stranded DNA-binding protein 2

3

3

Small-scale

0.667

High

568229

SSBP3
Single-stranded DNA-binding protein 3

3

4

Small-scale

0.667

High

568212

TAL2
T-cell acute lymphocytic leukemia protein 2

1

17

High-throughput

0.646

High

568225

SIN3A
Paired amphipathic helix protein Sin3a

2

2

Small-scale

0.629

High

568209

HDAC1
Histone deacetylase 1

2

7

Small-scale

0.621

High

568219

HDAC2
Histone deacetylase 2

2

7

Small-scale

0.621

High

568201

RUNX1
Runt-related transcription factor 1

2

4

Small-scale

0.618

High

568223

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

5

High-throughput

0.618

High

568173

TAL1
T-cell acute lymphocytic leukemia protein 1

1

18

Small-scale

0.618

High

568207

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

9

Small-scale

0.614

High

414158

RB
Retinoblastoma-associated protein

2

1

Small-scale

0.611

High

231993

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.597

High

554402

GATA1
Erythroid transcription factor

2

9

Small-scale

0.586

High

568235

CHIP
E3 ubiquitin-protein ligase CHIP

2

3

Small-scale

0.584

High

568221

KAT2B
Histone acetyltransferase KAT2B

1

7

Small-scale

0.578

High

434927

SP1
Transcription factor Sp1

1

5

Small-scale

0.573

High

568178

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

2

9

Small-scale

0.571

High

568233

RCOR1
REST corepressor 1

1

4

Small-scale

0.554

High

568236

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

Small-scale

0.554

High

567808

HXB9
Homeobox protein Hox-B9

1

20

High-throughput

0.541

High

568193

CDK9
Cyclin-dependent kinase 9

1

2

Small-scale

0.536

High

568211

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

Small-scale

0.536

High

568213

RBBP7
Histone-binding protein RBBP7

1

3

Small-scale

0.536

High

568231

SIR5
NAD-dependent protein deacylase sirtuin-5, mitochondrial

1

5

High-throughput

0.536

High

568239

SP16H
FACT complex subunit SPT16

1

1

Small-scale

0.536

High

568175

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

12

Small-scale

0.515

High

568215

NPNT
Nephronectin

1

1

High-throughput

0.515

High

568177

GATA2
Endothelial transcription factor GATA-2

1

9

Small-scale

0.508

High

568237

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

Small-scale

0.508

High

263506

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.500

High

541976

ETS1
Protein C-ets-1

1

15

Small-scale

0.500

High

568182

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.500

High

568185

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.500

High

568192

RBM25
RNA-binding protein 25

1

1

High-throughput

0.500

High

568214

UBR4
E3 ubiquitin-protein ligase UBR4

1

3

High-throughput

0.500

High

568224

HEXI2
Protein HEXIM2

1

3

High-throughput

0.500

High

568228

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.500

High

568230

BC11B
B-cell lymphoma/leukemia 11B

1

4

Small-scale

0.500

High

568234

ZHX1
Zinc fingers and homeoboxes protein 1

1

5

High-throughput

0.481

High

568181

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.479

High

568184

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.479

High

568189

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.479

High

568194

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.479

High

568197

PSA6
Proteasome subunit alpha type-6

1

0

High-throughput

0.479

High

568198

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.479

High

568227

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.479

High

176115

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.479

High

203438

MTG8R
Protein CBFA2T2

1

11

Small-scale

0.479

High

203622

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

5

Small-scale

0.479

High

319114

BRD1
Bromodomain-containing protein 1

1

7

Small-scale

0.479

High

455067

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

486737

MYB
Transcriptional activator Myb

1

1

Small-scale

0.479

High

508322

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.479

High

523504

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

536722

TRI27
Zinc finger protein RFP

1

2

Small-scale

0.479

High

550314

ZEP1
Zinc finger protein 40

1

7

High-throughput

0.479

High

568174

RCC1
Regulator of chromosome condensation

1

4

Small-scale

0.479

High

568186

CRK
Adapter molecule crk

1

5

High-throughput

0.479

High

568191

CTCF
Transcriptional repressor CTCF

1

4

High-throughput

0.479

High

568204

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

Small-scale

0.479

High

568208

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

568220

CBP
CREB-binding protein

1

15

High-throughput

0.479

High

568238

TRRAP
Transformation/transcription domain-associated protein

1

3

Small-scale

0.479

High

568218

CNDG2
Condensin-2 complex subunit G2

1

0

Small-scale

0.460

High

155525

TNPO2
Transportin-2

1

0

High-throughput

0.458

High

414562

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

568176

PTMS
Parathymosin

1

0

High-throughput

0.458

High

568202

SATB1
DNA-binding protein SATB1

1

0

Small-scale

0.458

High

568216

I2BP2
Interferon regulatory factor 2-binding protein 2

1

0

Small-scale

0.458

High

568222

ESPB1
Epididymal sperm-binding protein 1

1

1

Small-scale

0.457

High

489694

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.457

High

568196

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.457

High

568200

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

5

High-throughput

0.457

High

568205

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.457

High

568210

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.457

High

568232

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.457

High

568203

KPCT
Protein kinase C theta type

1

2

Small-scale

0.439

High

505932

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

2

High-throughput

0.437

High

281135

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.261

Low

541304

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.261

Low

568183

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.261

Low

568187

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.261

Low

568190

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.261

Low

568195

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.261

Low


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Last updated: 15 Jul 2024