Protein: RN166
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)

Gene: RN166, RNF166
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q96A37

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0006914 - autophagy
GO:0045087 - innate immune response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1283434

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

1283436

RN114
E3 ubiquitin-protein ligase RNF114

2

19

High-throughput

0.811

High

919812

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.800

High

849395

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

High-throughput

0.791

High

1055149

HLTF
Helicase-like transcription factor

2

5

High-throughput

0.789

High

896346

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

1151547

XAF1
XIAP-associated factor 1

4

7

Small-scale

0.702

High

851861

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

895868

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

908927

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1138899

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1283412

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1283418

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.698

High

1283422

RNF41
E3 ubiquitin-protein ligase NRDP1

1

18

High-throughput

0.698

High

1283423

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.698

High

1283424

TRI39
E3 ubiquitin-protein ligase TRIM39

1

19

High-throughput

0.698

High

280063

MPDZ
Multiple PDZ domain protein

3

19

High-throughput

0.667

High

310072

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

3

High-throughput

0.667

High

719576

MERL
Merlin

3

8

High-throughput

0.667

High

990906

ZO1
Tight junction protein ZO-1

3

13

High-throughput

0.667

High

1246419

INADL
InaD-like protein

3

19

High-throughput

0.667

High

1283421

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

3

3

High-throughput

0.667

High

228291

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.665

High

1283411

RN166
E3 ubiquitin-protein ligase RNF166

1

18

Small-scale

0.647

High

599703

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

17

High-throughput

0.628

High

1283419

PAR12
Protein mono-ADP-ribosyltransferase PARP12

2

13

High-throughput

0.628

High

1283432

CLC4E
C-type lectin domain family 4 member E

2

3

High-throughput

0.628

High

1282321

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.625

High

1283415

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.625

High

475125

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

1136639

DDI2
Protein DDI1 homolog 2

1

18

High-throughput

0.618

High

1283435

TRAF6
TNF receptor-associated factor 6

1

19

Small-scale

0.618

High

319958

HERC2
E3 ubiquitin-protein ligase HERC2

2

16

High-throughput

0.611

High

455739

PARP1
Poly [ADP-ribose] polymerase 1

2

16

High-throughput

0.611

High

579479

DNLI1
DNA ligase 1

2

3

High-throughput

0.611

High

828607

CENPF
Centromere protein F

2

12

High-throughput

0.611

High

1119017

AMOT
Angiomotin

2

19

High-throughput

0.611

High

1137414

HECD2
Probable E3 ubiquitin-protein ligase HECTD2

2

14

High-throughput

0.611

High

738686

TNR3
Tumor necrosis factor receptor superfamily member 3

3

20

High-throughput

0.609

High

1015778

KIF1A
Kinesin-like protein KIF1A

3

7

High-throughput

0.609

High

1203223

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

3

3

High-throughput

0.609

High

1222257

AMOL1
Angiomotin-like protein 1

3

17

High-throughput

0.609

High

1283426

PAR11
Protein mono-ADP-ribosyltransferase PARP11

3

13

High-throughput

0.609

High

1283420

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

High-throughput

0.586

High

476160

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.579

High

1283425

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

9

Small-scale

0.578

High

156709

TR13B
Tumor necrosis factor receptor superfamily member 13B

2

7

High-throughput

0.574

High

1252825

PLPR1
Phospholipid phosphatase-related protein type 1

2

3

High-throughput

0.574

High

1283413

CK024
Uncharacterized protein C11orf24

2

1

High-throughput

0.574

High

1283431

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

1

High-throughput

0.574

High

1036787

SQSTM
Sequestosome-1

1

14

Small-scale

0.561

High

1188227

NUP54
Nucleoporin p54

2

5

High-throughput

0.558

High

1283417

NUP58
Nucleoporin p58/p45

2

2

High-throughput

0.558

High

795655

MAGA1
Melanoma-associated antigen 1

1

11

Small-scale

0.552

High

1023524

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

3

High-throughput

0.541

High

234976

SNX3
Sorting nexin-3

1

2

High-throughput

0.536

High

805549

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

4

High-throughput

0.536

High

1115188

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

16

High-throughput

0.536

High

1188676

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

13

High-throughput

0.536

High

1221260

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

16

High-throughput

0.536

High

1238771

BOLL
Protein boule-like

1

12

High-throughput

0.536

High

1283427

BMP2K
BMP-2-inducible protein kinase

1

7

High-throughput

0.536

High

670376

AQP1
Aquaporin-1

1

1

High-throughput

0.515

High

794068

MATR3
Matrin-3

1

9

High-throughput

0.515

High

1283429

BABA2
BRISC and BRCA1-A complex member 2

1

0

High-throughput

0.513

High

1254605

MAGE2
Melanoma-associated antigen E2

1

11

Small-scale

0.504

High

351656

GLHA
Glycoprotein hormones alpha chain

1

1

High-throughput

0.489

High

503238

PPAL
Lysosomal acid phosphatase

1

1

High-throughput

0.489

High

836759

DNLI3
DNA ligase 3

1

1

High-throughput

0.489

High

957110

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

2

High-throughput

0.489

High

1139805

PLPP4
Phospholipid phosphatase 4

1

3

High-throughput

0.489

High

1231549

ARM10
Armadillo repeat-containing protein 10

1

3

High-throughput

0.489

High

1283416

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

271163

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

20

High-throughput

0.481

High

957752

XIAP
E3 ubiquitin-protein ligase XIAP

1

17

Small-scale

0.479

High

975196

ACY1
Aminoacylase-1

1

1

High-throughput

0.479

High

1024727

TRAF3
TNF receptor-associated factor 3

1

15

Small-scale

0.479

High

1042230

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1190047

MAVS
Mitochondrial antiviral-signaling protein

1

18

Small-scale

0.479

High

1025891

TADBP
TAR DNA-binding protein 43

1

18

High-throughput

0.470

High

236561

GMDS
GDP-mannose 4,6 dehydratase

1

0

High-throughput

0.458

High

1283414

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.458

High

1283430

MAGC2
Melanoma-associated antigen C2

1

11

Small-scale

0.439

High

858028

NUP98
Nuclear pore complex protein Nup98-Nup96

1

6

High-throughput

0.437

High

1283433

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.437

High

579721

XRCC1
DNA repair protein XRCC1

2

0

High-throughput

0.318

High

361672

APOC2
Apolipoprotein C-II

1

0

High-throughput

0.279

Low

1103718

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

1222677

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

1283428

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

225018

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.249

Low

1016833

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.249

Low

1244648

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024