Protein: FXL12
F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12)

Gene: FXL12, FBXL12
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q9NXK8

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

929084

SKP1
S-phase kinase-associated protein 1

10

20

Small-scale

0.974

High

1041229

CUL1
Cullin-1

7

20

Small-scale

0.960

High

1260219

STYX
Serine/threonine/tyrosine-interacting protein

4

3

Small-scale

0.686

High

899063

PSME3
Proteasome activator complex subunit 3

2

1

Small-scale

0.639

High

1244083

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.618

High

780209

CCNF
Cyclin-F

1

4

High-throughput

0.618

High

1347995

FXL12
F-box/LRR-repeat protein 12

1

8

Small-scale

0.618

High

884090

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.580

High

1252518

LNX1
E3 ubiquitin-protein ligase LNX

1

1

High-throughput

0.573

High

676770

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

3

Small-scale

0.561

High

758347

CDN1A
Cyclin-dependent kinase inhibitor 1

1

7

Small-scale

0.561

High

1327392

RNF32
RING finger protein 32

1

0

High-throughput

0.543

High

1256770

FBF1
Fas-binding factor 1

1

1

High-throughput

0.541

High

921445

RBX1
E3 ubiquitin-protein ligase RBX1

1

10

Small-scale

0.536

High

1184994

CSN6
COP9 signalosome complex subunit 6

1

3

High-throughput

0.536

High

1083021

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.518

High

614232

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.513

High

1312512

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.513

High

1347999

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1309247

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.504

High

895931

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

4

Small-scale

0.501

High

835011

PSN2
Presenilin-2

1

1

High-throughput

0.494

High

1347997

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

3

High-throughput

0.494

High

726447

BASI
Basigin

1

1

High-throughput

0.489

High

1347998

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.489

High

1348000

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

1348001

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

836907

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

6

Small-scale

0.488

High

157249

BACH1
Transcription regulator protein BACH1

1

20

Small-scale

0.479

High

427932

CAN1
Calpain-1 catalytic subunit

1

1

Small-scale

0.479

High

432307

HS90A
Heat shock protein HSP 90-alpha

1

13

High-throughput

0.479

High

438568

HS90B
Heat shock protein HSP 90-beta

1

15

High-throughput

0.479

High

448397

GSTP1
Glutathione S-transferase P

1

2

Small-scale

0.479

High

528038

RINI
Ribonuclease inhibitor

1

9

Small-scale

0.479

High

569017

CAN2
Calpain-2 catalytic subunit

1

1

Small-scale

0.479

High

795579

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

3

Small-scale

0.479

High

848982

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

3

Small-scale

0.479

High

1028474

SLAP1
Src-like-adapter

1

2

Small-scale

0.479

High

427678

ANXA2
Annexin A2

1

0

Small-scale

0.458

High

1101338

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1332684

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

834356

PSN1
Presenilin-1

1

1

High-throughput

0.439

High

402548

JUN
Transcription factor Jun

1

2

Small-scale

0.437

High

943765

PRAME
Melanoma antigen preferentially expressed in tumors

1

2

Small-scale

0.437

High

1070937

RCN1
Reticulocalbin-1

1

1

Small-scale

0.437

High

1159576

TTC27
Tetratricopeptide repeat protein 27

1

4

Small-scale

0.437

High

1059511

FXYD3
FXYD domain-containing ion transport regulator 3

1

0

High-throughput

0.282

High

245431

RAMP3
Receptor activity-modifying protein 3

1

0

High-throughput

0.279

Low

546641

ARSA
Arylsulfatase A

1

0

High-throughput

0.279

Low

873759

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.279

Low

1253047

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1347996

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.279

Low

344576

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.251

Low

361533

APOE
Apolipoprotein E

1

0

High-throughput

0.251

Low

254848

ASTN2
Astrotactin-2

1

0

Small-scale

0.249

Low

1128131

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

Small-scale

0.249

Low

1312481

HGH1
Protein HGH1 homolog

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024