Protein: PPGB
Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]

Gene: PPGB, CTSA
Organism: Homo sapiens
Interactions: 91
UniProt ID: P10619

Gene Ontology (top 5):
GO:0004180 - carboxypeptidase activity
GO:0004185 - serine-type carboxypeptidase activity
GO:0005576 - extracellular region
GO:0005764 - lysosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

495908

RHOA
Transforming protein RhoA

4

1

High-throughput

0.691

High

495958

FBX6
F-box only protein 6

3

1

High-throughput

0.656

High

436132

RHOC
Rho-related GTP-binding protein RhoC

2

1

High-throughput

0.628

High

495899

DNJB2
DnaJ homolog subfamily B member 2

3

1

High-throughput

0.609

High

495896

BGAL
Beta-galactosidase

1

0

High-throughput

0.586

High

368872

ESR1
Estrogen receptor

1

1

High-throughput

0.536

High

495898

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.536

High

495949

TX101
Testis-expressed protein 101

1

1

High-throughput

0.536

High

495955

LT4R2
Leukotriene B4 receptor 2

1

0

High-throughput

0.518

High

443286

VIME
Vimentin

1

0

High-throughput

0.513

High

495909

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.513

High

495960

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

495962

TAOK2
Serine/threonine-protein kinase TAO2

1

3

High-throughput

0.489

High

495963

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.489

High

157514

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.481

High

306930

CSPG5
Chondroitin sulfate proteoglycan 5

1

1

High-throughput

0.481

High

359597

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

1

High-throughput

0.481

High

495894

MUC1
Mucin-1

1

1

High-throughput

0.481

High

495895

LEUK
Leukosialin

1

1

High-throughput

0.481

High

495901

STX2
Syntaxin-2

1

1

High-throughput

0.481

High

495902

AQP2
Aquaporin-2

1

3

High-throughput

0.481

High

495910

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

1

High-throughput

0.481

High

495918

NACHO
Novel acetylcholine receptor chaperone

1

1

High-throughput

0.481

High

495919

F209A
Protein FAM209A

1

1

High-throughput

0.481

High

495921

MF14B
Hippocampus abundant transcript-like protein 1

1

6

High-throughput

0.481

High

495923

TM154
Transmembrane protein 154

1

1

High-throughput

0.481

High

495927

TM139
Transmembrane protein 139

1

1

High-throughput

0.481

High

495935

FNDC9
Fibronectin type III domain-containing protein 9

1

1

High-throughput

0.481

High

495937

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.481

High

495938

SSMM1
Serine-rich single-pass membrane protein 1

1

1

High-throughput

0.481

High

495942

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

1

High-throughput

0.481

High

495946

TM237
Transmembrane protein 237

1

1

High-throughput

0.481

High

495948

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

1

High-throughput

0.481

High

495952

REEP4
Receptor expression-enhancing protein 4

1

2

High-throughput

0.481

High

495954

RN122
RING finger protein 122

1

1

High-throughput

0.481

High

495957

SAR1A
Small COPII coat GTPase SAR1A

1

5

High-throughput

0.481

High

495965

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

High-throughput

0.481

High

495967

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

1

High-throughput

0.481

High

495903

HD
Huntingtin

1

1

High-throughput

0.479

High

495907

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

495941

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

495944

NECT4
Nectin-4

1

1

High-throughput

0.479

High

495947

NEUR1
Sialidase-1

1

1

Small-scale

0.479

High

495961

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

495959

CNBP1
Beta-catenin-interacting protein 1

1

1

High-throughput

0.470

High

495920

TMM31
Transmembrane protein 31

1

0

High-throughput

0.460

High

168716

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

0

Small-scale

0.458

High

213465

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

Small-scale

0.458

High

324192

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

495892

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

495915

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

495930

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

495932

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

495951

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

305921

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

495950

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

258392

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.439

High

495893

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

1

High-throughput

0.439

High

495900

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.439

High

495905

VMAT1
Chromaffin granule amine transporter

1

1

High-throughput

0.439

High

495912

AQP6
Aquaporin-6

1

3

High-throughput

0.439

High

495917

AR13B
ADP-ribosylation factor-like protein 13B

1

3

High-throughput

0.439

High

495922

GORAB
RAB6-interacting golgin

1

1

High-throughput

0.439

High

495926

CPLX4
Complexin-4

1

1

High-throughput

0.439

High

495928

AHNK2
Protein AHNAK2

1

1

High-throughput

0.439

High

495934

SMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2

1

1

High-throughput

0.439

High

495939

THAP4
Peroxynitrite isomerase THAP4

1

1

High-throughput

0.439

High

495940

BSND
Barttin

1

1

High-throughput

0.439

High

495945

SIG12
Sialic acid-binding Ig-like lectin 12

1

2

High-throughput

0.439

High

495966

TMX2
Thioredoxin-related transmembrane protein 2

1

1

High-throughput

0.439

High

204966

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

308354

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.437

High

373586

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.437

High

495897

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.437

High

495924

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

495943

CALR3
Calreticulin-3

1

3

High-throughput

0.437

High

495953

ECT2
Protein ECT2

1

1

High-throughput

0.437

High

495906

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

2

High-throughput

0.407

High

495933

KLDC9
Kelch domain-containing protein 9

2

0

High-throughput

0.328

High

495936

SFXN5
Sideroflexin-5

2

0

High-throughput

0.328

High

495925

MEPCE
7SK snRNA methylphosphate capping enzyme

2

0

High-throughput

0.305

High

495904

RORG
Nuclear receptor ROR-gamma

1

0

High-throughput

0.279

Low

495913

LAGE3
EKC/KEOPS complex subunit LAGE3

1

0

High-throughput

0.279

Low

495914

MD2BP
MAD2L1-binding protein

1

0

High-throughput

0.279

Low

495929

CI040
Uncharacterized protein C9orf40

1

0

High-throughput

0.279

Low

495931

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

0

High-throughput

0.279

Low

495964

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.279

Low

495916

SOAT
Sodium-dependent organic anion transporter

1

0

High-throughput

0.251

Low

233172

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

495956

ANLN
Anillin

1

0

High-throughput

0.249

Low

495911

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024