Protein: SIAH2
E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)

Gene: SIAH2
Organism: Homo sapiens
Interactions: 94
UniProt ID: O43255

Gene Ontology (top 5):
GO:0003714 - transcription corepressor activity
GO:0004842 - ubiquitin-protein transferase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

199125

SIAH1
E3 ubiquitin-protein ligase SIAH1

4

17

Small-scale

0.910

High

199069

SIAH2
E3 ubiquitin-protein ligase SIAH2

4

16

Small-scale

0.893

High

199091

SYUA
Alpha-synuclein

4

4

Small-scale

0.704

High

199103

UB2D3
Ubiquitin-conjugating enzyme E2 D3

4

20

Small-scale

0.688

High

199105

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

Small-scale

0.688

High

199149

EGLN3
Prolyl hydroxylase EGLN3

3

3

Small-scale

0.678

High

199081

ANDR
Androgen receptor

3

11

Small-scale

0.656

High

199099

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

20

Small-scale

0.655

High

199076

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

2

20

Small-scale

0.640

High

199151

LATS2
Serine/threonine-protein kinase LATS2

2

12

Small-scale

0.639

High

199074

PIAS1
E3 SUMO-protein ligase PIAS1

2

8

Small-scale

0.639

High

199106

UBC9
SUMO-conjugating enzyme UBC9

3

20

Small-scale

0.639

High

199122

SH3R1
E3 ubiquitin-protein ligase SH3RF1

2

13

Small-scale

0.636

High

199145

HIPK2
Homeodomain-interacting protein kinase 2

2

16

Small-scale

0.634

High

199138

CTIP
DNA endonuclease RBBP8

2

1

Small-scale

0.629

High

199157

SNCAP
Synphilin-1

2

8

Small-scale

0.629

High

199071

PRIC3
Prickle planar cell polarity protein 3

2

12

High-throughput

0.628

High

199126

SIAH3
Seven in absentia homolog 3

1

11

Small-scale

0.618

High

199090

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

2

0

Small-scale

0.603

High

199102

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

1

Small-scale

0.602

High

199137

EGLN2
Prolyl hydroxylase EGLN2

2

3

Small-scale

0.584

High

199143

EGLN1
Egl nine homolog 1

2

3

Small-scale

0.584

High

199078

CHK2
Serine/threonine-protein kinase Chk2

1

5

Small-scale

0.578

High

199114

ASPP2
Apoptosis-stimulating of p53 protein 2

1

13

Small-scale

0.578

High

199130

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

8

Small-scale

0.578

High

199084

VAV
Proto-oncogene vav

1

4

Small-scale

0.573

High

199085

PML
Protein PML

1

12

Small-scale

0.561

High

199095

AK1C3
Aldo-keto reductase family 1 member C3

1

1

Small-scale

0.561

High

199117

ZYX
Zyxin

1

14

Small-scale

0.561

High

199134

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

20

Small-scale

0.561

High

199136

ASPP1
Apoptosis-stimulating of p53 protein 1

1

11

Small-scale

0.561

High

199153

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

2

Small-scale

0.561

High

199119

NRF1
Nuclear respiratory factor 1

1

0

Small-scale

0.554

High

199127

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.554

High

161253

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

5

Small-scale

0.552

High

199120

XAF1
XIAP-associated factor 1

1

5

Small-scale

0.552

High

199144

PEG3
Paternally-expressed gene 3 protein

1

1

Small-scale

0.552

High

199141

TINF2
TERF1-interacting nuclear factor 2

1

0

Small-scale

0.549

High

199156

TPX2
Targeting protein for Xklp2

1

0

Small-scale

0.549

High

199108

PR20A
Proline-rich protein 20A

2

5

High-throughput

0.533

High

199124

PEG10
Retrotransposon-derived protein PEG10

1

1

Small-scale

0.527

High

199088

OPRM
Mu-type opioid receptor

1

7

Small-scale

0.523

High

199094

OPRK
Kappa-type opioid receptor

1

7

Small-scale

0.515

High

199101

ATN1
Atrophin-1

1

5

High-throughput

0.508

High

199146

HIPK3
Homeodomain-interacting protein kinase 3

1

20

High-throughput

0.508

High

199107

PR20E
Proline-rich protein 20E

2

5

High-throughput

0.504

High

199100

AFF1
AF4/FMR2 family member 1

1

7

Small-scale

0.501

High

199070

SPY2
Protein sprouty homolog 2

1

5

Small-scale

0.501

High

199104

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.501

High

199112

TRAF2
TNF receptor-associated factor 2

1

19

Small-scale

0.501

High

199116

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.501

High

199158

PIAS3
E3 SUMO-protein ligase PIAS3

1

8

Small-scale

0.501

High

199129

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

13

Small-scale

0.500

High

199121

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

1

6

High-throughput

0.494

High

199075

PIAS2
E3 SUMO-protein ligase PIAS2

1

8

Small-scale

0.481

High

199087

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.481

High

199092

STAT3
Signal transducer and activator of transcription 3

1

3

High-throughput

0.481

High

199096

DCC
Netrin receptor DCC

1

1

Small-scale

0.481

High

199139

MYD88
Myeloid differentiation primary response protein MyD88

1

19

High-throughput

0.481

High

199142

SETD2
Histone-lysine N-methyltransferase SETD2

1

2

High-throughput

0.481

High

158999

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

Small-scale

0.479

High

177132

HDAC3
Histone deacetylase 3

1

3

Small-scale

0.479

High

199072

CCNT1
Cyclin-T1

1

2

Small-scale

0.479

High

199077

LATS1
Serine/threonine-protein kinase LATS1

1

9

Small-scale

0.479

High

199082

BIP
Endoplasmic reticulum chaperone BiP

1

7

Small-scale

0.479

High

199086

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.479

High

199089

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

Small-scale

0.479

High

199097

CEBPD
CCAAT/enhancer-binding protein delta

1

2

Small-scale

0.479

High

199098

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

199110

ACK1
Activated CDC42 kinase 1

1

19

Small-scale

0.479

High

199111

EP300
Histone acetyltransferase p300

1

4

Small-scale

0.479

High

199113

CUL4B
Cullin-4B

1

13

High-throughput

0.479

High

199115

FLNC
Filamin-C

1

4

Small-scale

0.479

High

199118

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

199123

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

199131

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

Small-scale

0.479

High

199132

KAT2B
Histone acetyltransferase KAT2B

1

5

Small-scale

0.479

High

199133

KAT5
Histone acetyltransferase KAT5

1

2

Small-scale

0.479

High

199140

SENP7
Sentrin-specific protease 7

1

1

Small-scale

0.479

High

199147

WNK1
Serine/threonine-protein kinase WNK1

1

6

Small-scale

0.479

High

199148

PLK3
Serine/threonine-protein kinase PLK3

1

3

Small-scale

0.479

High

199152

PD1L1
Programmed cell death 1 ligand 1

1

4

Small-scale

0.479

High

199154

TES
Testin

1

13

Small-scale

0.479

High

199079

HMOX1
Heme oxygenase 1

1

0

Small-scale

0.458

High

199083

SKI
Ski oncogene

1

0

Small-scale

0.458

High

199128

PIWL2
Piwi-like protein 2

1

0

Small-scale

0.458

High

199135

EAF2
ELL-associated factor 2

1

0

Small-scale

0.458

High

199150

CYBP
Calcyclin-binding protein

1

4

Small-scale

0.457

High

199109

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

Small-scale

0.457

High

199155

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

2

Small-scale

0.457

High

199073

NCOR1
Nuclear receptor corepressor 1

1

9

Small-scale

0.445

High

199080

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

199093

OPRD
Delta-type opioid receptor

1

7

Small-scale

0.437

High


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Last updated: 15 Jul 2024