Protein: SPY2
Protein sprouty homolog 2 (Spry-2)

Gene: SPY2, SPRY2
Organism: Homo sapiens
Interactions: 149
UniProt ID: O43597

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

208093

CBL
E3 ubiquitin-protein ligase CBL

19

7

Small-scale

0.767

High

208125

GRB2
Growth factor receptor-bound protein 2

7

15

Small-scale

0.748

High

208177

SH3K1
SH3 domain-containing kinase-binding protein 1

3

18

Small-scale

0.680

High

208074

AAKB2
5'-AMP-activated protein kinase subunit beta-2

3

3

High-throughput

0.678

High

208116

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

3

14

High-throughput

0.674

High

208163

ZDH17
Palmitoyltransferase ZDHHC17

5

10

High-throughput

0.664

High

208183

KR412
Keratin-associated protein 4-12

2

20

High-throughput

0.646

High

208099

OTX1
Homeobox protein OTX1

2

2

High-throughput

0.640

High

208081

GRAP2
GRB2-related adapter protein 2

2

20

High-throughput

0.633

High

208130

MTG8
Protein CBFA2T1

2

1

High-throughput

0.633

High

208168

CTSR1
Cation channel sperm-associated protein 1

2

4

High-throughput

0.633

High

208070

SPY1
Protein sprouty homolog 1

2

15

Small-scale

0.631

High

208151

LCE1B
Late cornified envelope protein 1B

3

6

High-throughput

0.617

High

208124

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

1

High-throughput

0.611

High

208078

SNX3
Sorting nexin-3

2

0

High-throughput

0.585

High

208138

PLSI
Plastin-1

2

0

High-throughput

0.585

High

208126

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

1

Small-scale

0.584

High

208192

SPY4
Protein sprouty homolog 4

2

15

Small-scale

0.584

High

208194

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.578

High

208155

TENS2
Tensin-2

2

1

High-throughput

0.576

High

207285

FRS3
Fibroblast growth factor receptor substrate 3

1

1

High-throughput

0.573

High

208072

NCK2
Cytoplasmic protein NCK2

1

19

High-throughput

0.573

High

208080

STK16
Serine/threonine-protein kinase 16

1

4

High-throughput

0.573

High

208094

KRA59
Keratin-associated protein 5-9

1

20

High-throughput

0.573

High

208095

GRN
Progranulin

1

4

High-throughput

0.573

High

208096

AQP1
Aquaporin-1

1

3

High-throughput

0.573

High

208107

MEOX2
Homeobox protein MOX-2

1

10

High-throughput

0.573

High

208121

KR108
Keratin-associated protein 10-8

1

20

High-throughput

0.573

High

208122

KR109
Keratin-associated protein 10-9

1

20

High-throughput

0.573

High

208127

CREB5
Cyclic AMP-responsive element-binding protein 5

1

4

High-throughput

0.573

High

208144

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

3

High-throughput

0.573

High

208170

ZN417
Zinc finger protein 417

1

9

High-throughput

0.573

High

208172

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.573

High

208179

HEXI2
Protein HEXIM2

1

2

High-throughput

0.573

High

208180

ZN587
Zinc finger protein 587

1

8

High-throughput

0.573

High

208182

MDFI
MyoD family inhibitor

1

2

High-throughput

0.573

High

208188

KRA94
Keratin-associated protein 9-4

1

20

High-throughput

0.573

High

208189

KRA92
Keratin-associated protein 9-2

1

20

High-throughput

0.573

High

208190

KR411
Keratin-associated protein 4-11

1

20

High-throughput

0.573

High

208199

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

1

High-throughput

0.573

High

208205

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

2

High-throughput

0.573

High

208207

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

1

2

High-throughput

0.573

High

208208

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

2

High-throughput

0.573

High

208091

BRAF
Serine/threonine-protein kinase B-raf

1

3

Small-scale

0.561

High

208105

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

Small-scale

0.561

High

208129

KPCD
Protein kinase C delta type

1

1

Small-scale

0.561

High

208186

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

3

Small-scale

0.561

High

208079

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.549

High

208088

ACHG
Acetylcholine receptor subunit gamma

1

0

High-throughput

0.549

High

208090

GPIX
Platelet glycoprotein IX

1

0

High-throughput

0.549

High

208103

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

0

High-throughput

0.549

High

208156

KRA56
Keratin-associated protein 5-6

1

0

High-throughput

0.549

High

208175

ATRIP
ATR-interacting protein

1

0

High-throughput

0.549

High

208211

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.549

High

208069

SPY2
Protein sprouty homolog 2

1

14

High-throughput

0.541

High

208109

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

208110

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.541

High

208133

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.541

High

208134

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.541

High

208159

NUFP2
FMR1-interacting protein NUFIP2

1

1

High-throughput

0.541

High

208140

KPCD1
Serine/threonine-protein kinase D1

1

0

Small-scale

0.537

High

208115

CAV3
Caveolin-3

1

1

High-throughput

0.536

High

208162

ZDH13
Palmitoyltransferase ZDHHC13

1

10

High-throughput

0.536

High

208202

TES
Testin

1

3

High-throughput

0.536

High

208184

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

Small-scale

0.529

High

208076

MABP1
Mitogen-activated protein kinase-binding protein 1

1

2

High-throughput

0.523

High

208139

LASP1
LIM and SH3 domain protein 1

1

4

High-throughput

0.523

High

208146

LCE3C
Late cornified envelope protein 3C

1

1

High-throughput

0.523

High

208147

LCE3E
Late cornified envelope protein 3E

1

6

High-throughput

0.523

High

208152

LCE4A
Late cornified envelope protein 4A

1

1

High-throughput

0.523

High

208153

LCE2D
Late cornified envelope protein 2D

1

4

High-throughput

0.523

High

208195

CHRD
Chordin

1

8

High-throughput

0.523

High

208204

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

1

High-throughput

0.523

High

170007

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

208075

GRIN2
G protein-regulated inducer of neurite outgrowth 2

1

0

High-throughput

0.518

High

208085

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

Small-scale

0.515

High

208120

KR105
Keratin-associated protein 10-5

1

20

High-throughput

0.515

High

208123

KR10B
Keratin-associated protein 10-11

1

20

High-throughput

0.515

High

208157

Q6P2C6
MLLT6 protein

1

3

High-throughput

0.515

High

208191

KRA47
Keratin-associated protein 4-7

1

20

High-throughput

0.515

High

208100

CGL
Cystathionine gamma-lyase

1

0

High-throughput

0.513

High

208171

GNPI2
Glucosamine-6-phosphate isomerase 2

1

0

High-throughput

0.513

High

208181

S10AD
Protein S100-A13

1

0

High-throughput

0.513

High

208077

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.508

High

208086

CYTB
Cystatin-B

1

1

High-throughput

0.508

High

208108

DYN2
Dynamin-2

1

1

High-throughput

0.508

High

208113

NR1H2
Oxysterols receptor LXR-beta

1

5

High-throughput

0.508

High

208128

ZBT16
Zinc finger and BTB domain-containing protein 16

1

8

High-throughput

0.508

High

208136

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.508

High

208137

ZN266
Zinc finger protein 266

1

3

High-throughput

0.508

High

208165

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.508

High

199070

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

5

Small-scale

0.501

High

208132

KIF1A
Kinesin-like protein KIF1A

1

4

High-throughput

0.494

High

208158

ATL4
ADAMTS-like protein 4

1

3

High-throughput

0.494

High

208185

TRI51
Tripartite motif-containing protein 51

1

2

High-throughput

0.494

High

208196

BORG4
Cdc42 effector protein 4

1

0

High-throughput

0.493

High

208092

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.486

High

208112

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

0

High-throughput

0.486

High

208187

RTF2
Replication termination factor 2

1

0

High-throughput

0.486

High

208201

SEM5B
Semaphorin-5B

1

0

High-throughput

0.486

High

208082

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.481

High

208106

HXA1
Homeobox protein Hox-A1

1

16

High-throughput

0.481

High

208114

AF17
Protein AF-17

1

2

High-throughput

0.481

High

208118

KR101
Keratin-associated protein 10-1

1

20

High-throughput

0.481

High

208119

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.481

High

208135

DGCR6
Protein DGCR6

1

1

High-throughput

0.481

High

208142

ITSN1
Intersectin-1

1

1

High-throughput

0.481

High

208150

LCE1A
Late cornified envelope protein 1A

1

3

High-throughput

0.481

High

208167

TXND5
Thioredoxin domain-containing protein 5

1

1

High-throughput

0.481

High

208174

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

1

High-throughput

0.481

High

208210

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

159792

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.479

High

208071

SPY3
Protein sprouty homolog 3

1

15

Small-scale

0.479

High

208083

RASH
GTPase HRas

1

8

Small-scale

0.479

High

208084

RASK
GTPase KRas

1

9

High-throughput

0.479

High

208102

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

208104

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

208131

SOS1
Son of sevenless homolog 1

1

5

Small-scale

0.479

High

208141

TESK1
Dual specificity testis-specific protein kinase 1

1

6

Small-scale

0.479

High

208169

VANG1
Vang-like protein 1

1

1

High-throughput

0.479

High

208173

FRS2
Fibroblast growth factor receptor substrate 2

1

1

Small-scale

0.479

High

208176

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

1

High-throughput

0.479

High

208178

EGLN2
Prolyl hydroxylase EGLN2

1

2

Small-scale

0.479

High

208193

EGLN1
Egl nine homolog 1

1

2

Small-scale

0.479

High

208197

EGLN3
Prolyl hydroxylase EGLN3

1

2

Small-scale

0.479

High

208206

VANG2
Vang-like protein 2

1

1

High-throughput

0.479

High

208209

CAB39
Calcium-binding protein 39

1

1

High-throughput

0.479

High

208145

Q5JPT6
GIG10

1

18

High-throughput

0.470

High

208160

Q86UY0
protein disulfide-isomerase

1

1

High-throughput

0.470

High

208089

CATB
Cathepsin B

1

1

High-throughput

0.464

High

208101

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

3

High-throughput

0.464

High

208111

CRIP2
Cysteine-rich protein 2

1

2

High-throughput

0.464

High

208161

VPS36
Vacuolar protein-sorting-associated protein 36

1

0

Small-scale

0.460

High

208097

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

Small-scale

0.458

High

208143

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

Small-scale

0.458

High

208154

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

208203

CTNA3
Catenin alpha-3

1

0

Small-scale

0.458

High

208148

LCE1C
Late cornified envelope protein 1C

1

7

High-throughput

0.439

High

208149

LCE1F
Late cornified envelope protein 1F

1

3

High-throughput

0.439

High

208166

M21D2
Nucleotidyltransferase MB21D2

1

3

High-throughput

0.439

High

208117

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

208212

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

208200

FAIM1
Fas apoptotic inhibitory molecule 1

1

0

High-throughput

0.299

High

208073

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.279

Low

208087

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.279

Low

208098

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

208164

F219A
Protein FAM219A

1

0

High-throughput

0.265

Low

208198

TM14B
Transmembrane protein 14B

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024