Protein: CBLB
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)

Gene: CBLB
Organism: Mus musculus
Interactions: 70
UniProt ID: Q3TTA7

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002669 - positive regulation of T cell anergy
GO:0002870 - T cell anergy
GO:0005509 - calcium ion binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476784

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

2

9

Small-scale

0.778

High

1112050

CBLB
E3 ubiquitin-protein ligase CBL-B

2

12

Small-scale

0.768

High

610589

CBL
E3 ubiquitin-protein ligase CBL

2

9

Small-scale

0.737

High

895981

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

11

Small-scale

0.647

High

1112075

UBE2C
Ubiquitin-conjugating enzyme E2 C

1

12

Small-scale

0.647

High

607550

MYD88
Myeloid differentiation primary response protein MyD88

2

2

Small-scale

0.621

High

1112056

DTX1
E3 ubiquitin-protein ligase DTX1

1

1

Small-scale

0.618

High

1112063

CBLC
E3 ubiquitin-protein ligase CBL-C

1

5

Small-scale

0.618

High

815089

CRKL
Crk-like protein

2

20

Small-scale

0.588

High

719302

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

13

Small-scale

0.584

High

192485

SMAD7
Mothers against decapentaplegic homolog 7

1

3

Small-scale

0.561

High

1112061

TCAM1
TIR domain-containing adapter molecule 1

1

7

Small-scale

0.554

High

222771

LAT
Linker for activation of T-cells family member 1

2

2

High-throughput

0.552

High

1112053

GRB2
Growth factor receptor-bound protein 2

2

20

Small-scale

0.552

High

526813

CD5
T-cell surface glycoprotein CD5

1

2

High-throughput

0.536

High

411924

LCK
Proto-oncogene tyrosine-protein kinase LCK

1

20

Small-scale

0.501

High

782847

CSK
Tyrosine-protein kinase CSK

1

20

High-throughput

0.484

High

665985

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

13

Small-scale

0.479

High

815729

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.479

High

969028

KPCT
Protein kinase C theta type

1

5

Small-scale

0.479

High

1112057

SRBS1
Sorbin and SH3 domain-containing protein 1

1

20

Small-scale

0.479

High

1112058

CRK
Adapter molecule crk

1

20

Small-scale

0.479

High

1112066

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

Small-scale

0.479

High

1112069

EED
Polycomb protein EED

1

7

High-throughput

0.479

High

1112077

ARHG7
Rho guanine nucleotide exchange factor 7

1

19

Small-scale

0.479

High

1112068

S12A5
Solute carrier family 12 member 5

1

0

Small-scale

0.458

High

1112079

TLR4
Toll-like receptor 4

1

0

Small-scale

0.458

High

223012

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.445

High

292684

GRAP2
GRB2-related adaptor protein 2

1

20

High-throughput

0.445

High

535303

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.445

High

586558

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.445

High

796500

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.445

High

893224

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.445

High

900330

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.445

High

907798

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.445

High

910632

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.445

High

911594

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.445

High

912770

SMD3
Small nuclear ribonucleoprotein Sm D3

1

1

High-throughput

0.445

High

922038

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.445

High

923921

PROF1
Profilin-1

1

6

High-throughput

0.445

High

926126

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.445

High

930127

RS17
Small ribosomal subunit protein eS17

1

1

High-throughput

0.445

High

930592

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.445

High

952253

H32
Histone H3.2

1

14

High-throughput

0.445

High

1112052

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

20

High-throughput

0.445

High

1112054

LCP2
Lymphocyte cytosolic protein 2

1

9

High-throughput

0.445

High

1112055

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

15

High-throughput

0.445

High

1112059

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.445

High

1112062

AN13A
Ankyrin repeat domain-containing protein 13A

1

8

High-throughput

0.445

High

1112064

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.445

High

1112072

GRAP
GRB2-related adapter protein

1

20

High-throughput

0.445

High

1112074

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.445

High

1112078

RL38
Large ribosomal subunit protein eL38

1

2

High-throughput

0.445

High

1112081

ITSN2
Intersectin-2

1

20

High-throughput

0.445

High

1112051

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

3

Small-scale

0.437

High

1112060

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

8

Small-scale

0.437

High

815137

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.426

High

919601

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.426

High

932080

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.426

High

1112065

LAX1
Lymphocyte transmembrane adapter 1

1

0

High-throughput

0.426

High

1112080

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.426

High

517630

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.408

High

751915

GRP75
Stress-70 protein, mitochondrial

1

9

High-throughput

0.407

High

907208

PRS8
26S proteasome regulatory subunit 8

1

4

High-throughput

0.407

High

1112067

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.407

High

1112071

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

4

High-throughput

0.407

High

1112070

PSMD6
26S proteasome non-ATPase regulatory subunit 6

2

0

Small-scale

0.298

High

1112073

GAPR1
Golgi-associated plant pathogenesis-related protein 1

1

0

High-throughput

0.232

Low

1112076

ATPD
ATP synthase subunit delta, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024