Protein: IRAK1
Interleukin-1 receptor-associated kinase 1 (IRAK) (IRAK-1) (EC 2.7.11.1) (Pelle-like protein kinase) (mPLK)

Gene: IRAK1
Organism: Mus musculus
Interactions: 50
UniProt ID: Q62406

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005149 - interleukin-1 receptor binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607559

MYD88
Myeloid differentiation primary response protein MyD88

9

20

Small-scale

0.968

High

528286

IL1R1
Interleukin-1 receptor type 1

4

12

Small-scale

0.881

High

1143879

IRAK1
Interleukin-1 receptor-associated kinase 1

3

20

Small-scale

0.834

High

1143890

IRAK4
Interleukin-1 receptor-associated kinase 4

3

20

Small-scale

0.829

High

1143889

IRAK3
Interleukin-1 receptor-associated kinase 3

2

20

Small-scale

0.754

High

936236

TRAF6
TNF receptor-associated factor 6

8

12

Small-scale

0.746

High

1143880

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

1

Small-scale

0.690

High

554914

KPCE
Protein kinase C epsilon type

1

5

Small-scale

0.665

High

1143252

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

20

Small-scale

0.665

High

1143899

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.665

High

626868

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.618

High

1142214

FADD
FAS-associated death domain protein

1

2

Small-scale

0.618

High

1143900

IKBA
NF-kappa-B inhibitor alpha

1

5

Small-scale

0.618

High

1143898

TOLIP
Toll-interacting protein

2

2

Small-scale

0.601

High

880601

IRF5
Interferon regulatory factor 5

2

2

Small-scale

0.584

High

1143895

TLR4
Toll-like receptor 4

2

20

Small-scale

0.584

High

1143897

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.561

High

192830

NOTC2
Neurogenic locus notch homolog protein 2

1

0

High-throughput

0.560

High

1143892

ANR17
Ankyrin repeat domain-containing protein 17

1

0

High-throughput

0.560

High

786541

STAT3
Signal transducer and activator of transcription 3

1

2

Small-scale

0.515

High

1143883

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

11

Small-scale

0.515

High

1143886

RSAD2
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2

1

1

Small-scale

0.515

High

761818

TRAF2
TNF receptor-associated factor 2

1

12

Small-scale

0.479

High

886459

SENP1
Sentrin-specific protease 1

1

1

Small-scale

0.479

High

1112910

FBW1A
F-box/WD repeat-containing protein 1A

1

2

Small-scale

0.479

High

1143080

IL1AP
Interleukin-1 receptor accessory protein

1

18

Small-scale

0.479

High

1143679

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

1

Small-scale

0.479

High

1143885

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

11

Small-scale

0.479

High

1143893

TLR9
Toll-like receptor 9

1

20

Small-scale

0.479

High

1143881

RNF41
E3 ubiquitin-protein ligase NRDP1

1

12

Small-scale

0.470

High

501143

OSTP
Osteopontin

1

0

Small-scale

0.458

High

665990

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

0

Small-scale

0.458

High

793616

LIT1
Lithostathine-1

1

0

Small-scale

0.458

High

998233

DLK1
Protein delta homolog 1

1

1

High-throughput

0.457

High

1141987

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

High-throughput

0.457

High

1143888

Q8K2C1
Aamp protein

1

1

High-throughput

0.457

High

1143894

PARVG
Gamma-parvin

1

1

High-throughput

0.457

High

437545

S10AA
Protein S100-A10

1

0

High-throughput

0.438

High

485984

ANXA1
Annexin A1

1

0

High-throughput

0.438

High

850518

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.438

High

1111872

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.438

High

1143882

EEA1
Early endosome antigen 1

1

0

High-throughput

0.438

High

1143884

MDFIC
MyoD family inhibitor domain-containing protein

1

0

High-throughput

0.438

High

1143887

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.438

High

1143891

LPXN
Leupaxin

1

0

High-throughput

0.438

High

1143896

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.438

High

1142170

IL18R
Interleukin-18 receptor 1

1

18

Small-scale

0.437

High

742646

FBLN2
Fibulin-2

1

1

High-throughput

0.417

High

192792

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024