Protein: DKK2
Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2)

Gene: DKK2
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q9UBU2

Gene Ontology (top 5):
GO:0005615 - extracellular space
GO:0016055 - Wnt signaling pathway
GO:0039706 - co-receptor binding
GO:0048019 - receptor antagonist activity
GO:0090090 - negative regulation of canonical Wnt signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

270344

LRP6
Low-density lipoprotein receptor-related protein 6

2

8

Small-scale

0.619

High

889209

KR106
Keratin-associated protein 10-6

2

1

High-throughput

0.553

High

416532

S10A9
Protein S100-A9

1

1

High-throughput

0.536

High

668058

SPB3
Serpin B3

1

1

High-throughput

0.536

High

678520

S10A7
Protein S100-A7

1

1

High-throughput

0.536

High

820401

SPB4
Serpin B4

1

1

High-throughput

0.536

High

935839

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.536

High

936094

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.536

High

1269032

SORL
Sortilin-related receptor

1

8

High-throughput

0.536

High

364621

TRFE
Serotransferrin

1

0

High-throughput

0.513

High

428735

TRY2
Trypsin-2

1

0

High-throughput

0.513

High

533254

PLSL
Plastin-2

1

0

High-throughput

0.513

High

804359

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

815043

LEG7
Galectin-7

1

0

High-throughput

0.513

High

945753

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.513

High

1257261

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.513

High

195764

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

1

High-throughput

0.489

High

216600

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.489

High

258359

LRP5
Low-density lipoprotein receptor-related protein 5

1

8

High-throughput

0.489

High

354782

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

1

High-throughput

0.489

High

666511

ARI4A
AT-rich interactive domain-containing protein 4A

1

1

High-throughput

0.489

High

957657

LRP2
Low-density lipoprotein receptor-related protein 2

1

8

High-throughput

0.489

High

1117712

ARI4B
AT-rich interactive domain-containing protein 4B

1

1

High-throughput

0.489

High

1129663

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

2

High-throughput

0.489

High

1133268

HECD3
E3 ubiquitin-protein ligase HECTD3

1

1

High-throughput

0.489

High

1293656

SAHH3
Adenosylhomocysteinase 3

1

1

High-throughput

0.489

High

1333163

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

2

High-throughput

0.489

High

1336546

BRMS1
Breast cancer metastasis-suppressor 1

1

2

High-throughput

0.489

High

1349412

LRP1B
Low-density lipoprotein receptor-related protein 1B

1

9

High-throughput

0.489

High

354902

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

1

High-throughput

0.437

High

353827

IGHG2
Immunoglobulin heavy constant gamma 2

1

0

High-throughput

0.426

High

265275

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.279

Low

422585

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.279

Low

428646

INVO
Involucrin

1

0

High-throughput

0.279

Low

443862

VIME
Vimentin

1

0

High-throughput

0.279

Low

533999

ANXA8
Annexin A8

1

0

High-throughput

0.279

Low

611357

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

675065

KPYR
Pyruvate kinase PKLR

1

0

High-throughput

0.279

Low

1197775

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

1216216

TF2LX
Homeobox protein TGIF2LX

1

0

High-throughput

0.279

Low

1288754

RSPRY
RING finger and SPRY domain-containing protein 1

1

0

High-throughput

0.279

Low

1302464

SIN3A
Paired amphipathic helix protein Sin3a

1

0

High-throughput

0.279

Low

1312497

DHRS4
Dehydrogenase/reductase SDR family member 4

1

0

High-throughput

0.279

Low

1327632

SP130
Histone deacetylase complex subunit SAP130

1

0

High-throughput

0.279

Low

1354322

ING1
Inhibitor of growth protein 1

1

0

High-throughput

0.279

Low

1354323

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.279

Low

734800

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.249

Low

484340

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024