Protein: PP1R8
Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]

Gene: PP1R8, PPP1R8
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q12972

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0004519 - endonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1021761

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

7

Small-scale

0.777

High

905861

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

19

9

Small-scale

0.767

High

737777

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

14

9

Small-scale

0.762

High

268696

SF3B1
Splicing factor 3B subunit 1

1

5

Small-scale

0.740

High

906435

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

6

9

Small-scale

0.738

High

1021749

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

10

High-throughput

0.691

High

1021770

APBP2
Amyloid protein-binding protein 2

3

1

High-throughput

0.675

High

568644

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.647

High

268058

EED
Polycomb protein EED

2

9

Small-scale

0.636

High

503992

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.628

High

1021776

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

2

High-throughput

0.628

High

1021757

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

Small-scale

0.624

High

1021754

SETB1
Histone-lysine N-methyltransferase SETDB1

2

4

Small-scale

0.614

High

664075

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

1021767

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

1021748

TIF1B
Transcription intermediary factor 1-beta

2

6

Small-scale

0.584

High

433733

LYN
Tyrosine-protein kinase Lyn

1

1

Small-scale

0.561

High

1021773

CNKR1
Connector enhancer of kinase suppressor of ras 1

1

0

Small-scale

0.541

High

1021771

HDAC2
Histone deacetylase 2

1

0

Small-scale

0.537

High

201786

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

4

High-throughput

0.536

High

274733

RA51D
DNA repair protein RAD51 homolog 4

1

2

High-throughput

0.536

High

446609

SNRPA
U1 small nuclear ribonucleoprotein A

1

5

High-throughput

0.536

High

448633

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

508488

TOP1
DNA topoisomerase 1

1

1

High-throughput

0.536

High

538930

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.536

High

911817

RUXF
Small nuclear ribonucleoprotein F

1

4

High-throughput

0.536

High

960046

HXC5
Homeobox protein Hox-C5

1

1

High-throughput

0.536

High

996640

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.536

High

1021750

DX39B
Spliceosome RNA helicase DDX39B

1

2

High-throughput

0.536

High

1021752

RBM39
RNA-binding protein 39

1

3

High-throughput

0.536

High

1021756

SF3A1
Splicing factor 3A subunit 1

1

1

High-throughput

0.536

High

1021758

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

4

High-throughput

0.536

High

564879

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.527

High

690142

GBP2
Guanylate-binding protein 2

1

0

High-throughput

0.518

High

1021760

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

607646

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.515

High

257999

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

574313

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

1021786

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

1021778

MEP50
Methylosome protein WDR77

1

3

High-throughput

0.508

High

1021784

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

1

1

High-throughput

0.508

High

1021777

CDC5L
Cell division cycle 5-like protein

1

3

Small-scale

0.506

High

394629

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1021765

FBX25
F-box only protein 25

1

1

Small-scale

0.501

High

1021751

DPYL1
Dihydropyrimidinase-related protein 1

1

1

High-throughput

0.494

High

1021785

WIF1
Wnt inhibitory factor 1

1

1

High-throughput

0.489

High

1021769

CTBL1
Beta-catenin-like protein 1

1

0

High-throughput

0.486

High

1021772

CBP
CREB-binding protein

1

7

Small-scale

0.481

High

244364

BRD4
Bromodomain-containing protein 4

1

6

High-throughput

0.479

High

641747

U2AF2
Splicing factor U2AF 65 kDa subunit

1

3

High-throughput

0.479

High

940841

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

997696

RBBP4
Histone-binding protein RBBP4

1

1

Small-scale

0.479

High

1018936

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

1021755

SF3A2
Splicing factor 3A subunit 2

1

2

High-throughput

0.479

High

1021763

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1021766

BICD2
Protein bicaudal D homolog 2

1

4

High-throughput

0.479

High

1021774

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1021775

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.479

High

1021779

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1021781

PRP19
Pre-mRNA-processing factor 19

1

10

High-throughput

0.479

High

1021782

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

5

High-throughput

0.479

High

233412

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

1021753

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.458

High

1021762

LMTK1
Serine/threonine-protein kinase LMTK1

1

9

High-throughput

0.437

High

388879

CP1A1
Cytochrome P450 1A1

3

0

High-throughput

0.347

High

1021768

RT4I1
Reticulon-4-interacting protein 1, mitochondrial

2

0

High-throughput

0.316

High

282414

STC2
Stanniocalcin-2

1

0

High-throughput

0.282

High

1021780

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

611236

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

0

High-throughput

0.279

Low

1021764

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.279

Low

1021783

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

352087

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1021759

PPR3A
Protein phosphatase 1 regulatory subunit 3A

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024