Protein: SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship)

Gene: SHIP1, Inpp5d
Organism: Mus musculus
Interactions: 38
UniProt ID: Q9ES52

Gene Ontology (top 5):
GO:0004439 - phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 - inositol-polyphosphate 5-phosphatase activity
GO:0005829 - cytosol
GO:0005884 - actin filament
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957245

SHC1
SHC-transforming protein 1

6

20

Small-scale

0.944

High

337638

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.806

High

815098

CRKL
Crk-like protein

1

20

Small-scale

0.724

High

1112232

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

1

High-throughput

0.646

High

956525

DOK1
Docking protein 1

2

7

Small-scale

0.639

High

610647

CBL
E3 ubiquitin-protein ligase CBL

3

2

Small-scale

0.633

High

1322348

SLAF1
Signaling lymphocytic activation molecule

2

20

Small-scale

0.629

High

403460

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.618

High

643112

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

18

Small-scale

0.618

High

719318

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

2

Small-scale

0.618

High

729763

BTK
Tyrosine-protein kinase BTK

1

20

Small-scale

0.618

High

956956

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

9

Small-scale

0.618

High

1141165

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.618

High

1142194

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

10

Small-scale

0.618

High

1143295

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

Small-scale

0.618

High

1322350

ZO2
Tight junction protein ZO-2

1

3

Small-scale

0.618

High

1208606

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

3

High-throughput

0.590

High

770717

CSF3R
Granulocyte colony-stimulating factor receptor

1

0

Small-scale

0.586

High

1141386

LCP2
Lymphocyte cytosolic protein 2

1

0

High-throughput

0.546

High

222483

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

Small-scale

0.537

High

1321920

Q9D031
Ras suppressor protein 1

1

0

Small-scale

0.517

High

250958

DOK2
Docking protein 2

1

7

High-throughput

0.489

High

722908

CD22
B-cell receptor CD22

1

4

Small-scale

0.479

High

1111653

STING
Stimulator of interferon genes protein

1

2

High-throughput

0.479

High

1207798

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1246940

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

Small-scale

0.479

High

1307898

LPXN
Leupaxin

1

2

Small-scale

0.479

High

1322322

PARVG
Gamma-parvin

1

7

Small-scale

0.479

High

1322349

DOK3
Docking protein 3

1

7

Small-scale

0.479

High

677653

CTND1
Catenin delta-1

1

0

Small-scale

0.458

High

964762

SC23A
Protein transport protein Sec23A

1

0

Small-scale

0.458

High

1164424

CLM8
CMRF35-like molecule 8

1

0

Small-scale

0.458

High

1194179

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.458

High

1307716

FOXP3
Forkhead box protein P3

1

0

High-throughput

0.458

High

1307807

DCTN2
Dynactin subunit 2

1

0

Small-scale

0.458

High

435874

FCGR2
Low affinity immunoglobulin gamma Fc region receptor II

1

8

Small-scale

0.445

High

897169

ACTZ
Alpha-centractin

1

7

Small-scale

0.437

High

222803

LAT
Linker for activation of T-cells family member 1

1

0

High-throughput

0.426

High


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Last updated: 15 Jul 2024