Protein: APLF
Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1)

Gene: APLF
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q8IW19

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000166 - nucleotide binding
GO:0003906 - DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004520 - DNA endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

455627

PARP1
Poly [ADP-ribose] polymerase 1

7

3

Small-scale

0.753

High

524977

XRCC5
X-ray repair cross-complementing protein 5

6

1

Small-scale

0.737

High

523866

XRCC6
X-ray repair cross-complementing protein 6

6

1

Small-scale

0.730

High

579716

XRCC1
DNA repair protein XRCC1

7

0

Small-scale

0.719

High

836846

DNLI4
DNA ligase 4

5

1

Small-scale

0.716

High

1033959

XRCC4
DNA repair protein XRCC4

6

0

Small-scale

0.701

High

1218138

PARP2
Poly [ADP-ribose] polymerase 2

4

2

Small-scale

0.696

High

260927

H2AY
Core histone macro-H2A.1

4

6

Small-scale

0.694

High

836748

DNLI3
DNA ligase 3

4

1

Small-scale

0.691

High

1203216

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

5

0

Small-scale

0.684

High

470443

H2A1
Histone H2A type 1

3

4

High-throughput

0.667

High

1218133

H2B1A
Histone H2B type 1-A

3

1

High-throughput

0.667

High

1218137

H2AW
Core histone macro-H2A.2

3

6

High-throughput

0.667

High

417831

DPOLB
DNA polymerase beta

3

0

High-throughput

0.638

High

781565

CETN2
Centrin-2

3

0

High-throughput

0.638

High

967051

XPC
DNA repair protein complementing XP-C cells

3

0

High-throughput

0.638

High

996756

SSRP1
FACT complex subunit SSRP1

3

0

High-throughput

0.638

High

1055133

HLTF
Helicase-like transcription factor

3

0

High-throughput

0.638

High

1218136

TYDP1
Tyrosyl-DNA phosphodiesterase 1

3

0

High-throughput

0.638

High

1218140

SP16H
FACT complex subunit SPT16

3

0

High-throughput

0.638

High

1087041

H2A2C
Histone H2A type 2-C

2

4

Small-scale

0.611

High

1216219

H2A2B
Histone H2A type 2-B

2

4

High-throughput

0.611

High

344871

CYTS
Cystatin-S

3

1

High-throughput

0.609

High

594201

MSH3
DNA mismatch repair protein Msh3

2

0

High-throughput

0.602

High

1086207

H31T
Histone H3.1t

2

2

Small-scale

0.584

High

1136674

H37
Histone H3-7

2

2

High-throughput

0.552

High

508607

TOP1
DNA topoisomerase 1

2

0

Small-scale

0.547

High

391779

H2A1B
Histone H2A type 1-B/E

1

4

High-throughput

0.536

High

1151351

H2A2A
Histone H2A type 2-A

1

4

High-throughput

0.536

High

1121893

Q53SE7
Germ cell-less homolog 1

1

1

High-throughput

0.515

High

1031561

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.501

High

1218141

PARP3
Protein mono-ADP-ribosyltransferase PARP3

1

2

Small-scale

0.501

High

344994

CYTN
Cystatin-SN

1

1

High-throughput

0.489

High

1218135

GMCL1
Germ cell-less protein-like 1

1

1

High-throughput

0.481

High

395122

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1218132

FBX25
F-box only protein 25

1

0

Small-scale

0.480

High

420852

H2B1J
Histone H2B type 1-J

1

1

High-throughput

0.479

High

934952

H31
Histone H3.1

1

2

High-throughput

0.479

High

1218139

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

944313

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.445

High

651623

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.426

High

801912

RECQ1
ATP-dependent DNA helicase Q1

1

0

Small-scale

0.426

High

898381

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.426

High

931259

YBOX1
Y-box-binding protein 1

1

0

Small-scale

0.426

High

1218134

PAUF
Pancreatic adenocarcinoma up-regulated factor

3

0

High-throughput

0.347

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024