Protein: EZ
Histone-lysine N-methyltransferase E(z) (EC 2.1.1.356) (Lysine N-methyltransferase 6) (Protein enhancer of zeste)

Gene: EZ, E(z)
Organism: Drosophila melanogaster
Interactions: 43
UniProt ID: P42124

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

785624

ESC
Polycomb protein esc

25

20

Small-scale

0.991

High

785634

SUZ12
Polycomb protein Su(z)12

10

10

Small-scale

0.975

High

785628

CAF1
Chromatin assembly factor 1 p55 subunit

8

20

Small-scale

0.962

High

356072

H3
Histone H3

3

20

Small-scale

0.856

High

785620

EZ
Histone-lysine N-methyltransferase E(z)

2

18

Small-scale

0.768

High

785644

Q9VKD5
Escl, isoform A

2

20

Small-scale

0.754

High

785626

PCL
Polycomb protein Pcl

7

20

Small-scale

0.752

High

785632

HDAC1
Histone deacetylase HDAC1

3

20

Small-scale

0.685

High

785631

PHO
Polycomb protein PHO

3

10

Small-scale

0.661

High

785647

Q9VT00
Jumonji, AT rich interactive domain 2

3

12

Small-scale

0.633

High

785621

H2A
Histone H2A

1

14

Small-scale

0.618

High

780461

CORTO
Centrosomal and chromosomal factor

2

0

Small-scale

0.605

High

398991

HP1
Heterochromatin protein 1

2

20

Small-scale

0.595

High

785639

SAP18
Histone deacetylase complex subunit SAP18

1

2

Small-scale

0.586

High

785633

Q95SW6
SD02661p

1

16

Small-scale

0.536

High

785649

Q9W3D5
LD20420p

1

13

High-throughput

0.508

High

785638

INO80
Chromatin-remodeling ATPase INO80

1

18

High-throughput

0.484

High

359251

HSP27
Heat shock protein 27

1

3

Small-scale

0.479

High

639955

PC
Polycomb group protein Pc

1

20

Small-scale

0.479

High

785622

GAGA
Transcription activator GAGA

1

12

Small-scale

0.479

High

785627

RBF
Retinoblastoma family protein

1

8

Small-scale

0.479

High

785630

JING
Zinc finger protein jing

1

10

Small-scale

0.479

High

785636

ASX
Polycomb group protein Asx

1

13

Small-scale

0.479

High

785637

RING1
E3 ubiquitin-protein ligase RING1

1

18

Small-scale

0.479

High

785640

Q9VF04
RE32990p

1

8

Small-scale

0.479

High

785643

SCM
Polycomb protein Scm

1

8

Small-scale

0.479

High

785645

PIWI
Protein piwi

1

3

Small-scale

0.479

High

785646

Q9VP12
Structural maintenance of chromosomes protein 5

1

12

Small-scale

0.479

High

785652

NU931
Nuclear pore complex protein Nup93-1

1

2

Small-scale

0.479

High

415590

TBA1
Tubulin alpha-1 chain

1

8

Small-scale

0.445

High

505052

HSP7D
Heat shock 70 kDa protein cognate 4

1

3

Small-scale

0.445

High

785623

Q24113
FI21126p1

1

9

Small-scale

0.445

High

785635

JIL1
Chromosomal serine/threonine-protein kinase JIL-1

1

6

High-throughput

0.445

High

785642

Q9VH81
protein-serine/threonine phosphatase

1

6

High-throughput

0.445

High

785650

Q9W3M7
RNA helicase

1

7

Small-scale

0.445

High

785651

Q9W542
LD07342p

1

2

High-throughput

0.445

High

785641

Q9VFE7
Nuclear pore protein

1

2

Small-scale

0.437

High

780566

PEP
Zinc finger protein on ecdysone puffs

1

0

Small-scale

0.426

High

785625

LACH
Lachesin

1

1

High-throughput

0.407

High

785629

Q7JQF6
HL05804p

1

1

High-throughput

0.407

High

284182

O76874
SD17974p

1

0

High-throughput

0.232

Low

785648

Q9VX17
LD36024p

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024