Protein: UBP8
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)

Gene: UBP8
Organism: Saccharomyces cerevisiae S288C
Interactions: 190
UniProt ID: P50102

Gene Ontology (top 5):
GO:0000124 - SAGA complex
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

837442

SGF73
SAGA-associated factor 73

15

9

Small-scale

0.983

High

837485

SUS1
Transcription and mRNA export factor SUS1

15

5

Small-scale

0.982

High

744649

TAF5
Transcription initiation factor TFIID subunit 5

10

15

Small-scale

0.969

High

837438

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

6

13

Small-scale

0.939

High

837457

SGF11
SAGA-associated factor 11

13

0

Small-scale

0.929

High

477366

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

3

20

Small-scale

0.866

High

715356

SPT7
Transcriptional activator SPT7

18

20

Small-scale

0.763

High

837453

ADA2
Transcriptional adapter 2

17

9

Small-scale

0.763

High

837458

GCN5
Histone acetyltransferase GCN5

17

20

Small-scale

0.763

High

837477

HFI1
Transcriptional coactivator HFI1/ADA1

11

1

Small-scale

0.754

High

837441

TAF6
Transcription initiation factor TFIID subunit 6

10

3

Small-scale

0.753

High

691327

NGG1
Chromatin-remodeling complexes subunit NGG1

10

3

Small-scale

0.751

High

837460

TAF12
Transcription initiation factor TFIID subunit 12

10

3

Small-scale

0.751

High

420614

SPT3
Protein SPT3

10

4

Small-scale

0.751

High

755432

TRA1
Transcription-associated protein 1

8

9

Small-scale

0.747

High

633876

SGF29
SAGA-associated factor 29

8

5

Small-scale

0.746

High

837476

TAF10
Transcription initiation factor TFIID subunit 10

8

1

Small-scale

0.746

High

837466

TAF9
Transcription initiation factor TFIID subunit 9

7

5

Small-scale

0.740

High

757439

SPT8
Transcription factor SPT8

11

0

Small-scale

0.723

High

837439

SPT20
Transcription factor SPT20

10

0

Small-scale

0.720

High

703690

PRS6A
26S proteasome regulatory subunit 6A

1

7

High-throughput

0.691

High

375443

RPB1
DNA-directed RNA polymerase II subunit RPB1

4

2

Small-scale

0.672

High

687430

EF2
Elongation factor 2

1

4

High-throughput

0.618

High

355547

H2B1
Histone H2B.1

2

20

Small-scale

0.602

High

355943

H2B2
Histone H2B.2

2

20

Small-scale

0.602

High

392501

H2A2
Histone H2A.2

2

18

High-throughput

0.588

High

687716

BTAF1
TATA-binding protein-associated factor MOT1

2

10

Small-scale

0.584

High

408408

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

15

High-throughput

0.575

High

762765

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

18

High-throughput

0.575

High

771721

PRS4
26S proteasome regulatory subunit 4 homolog

1

6

High-throughput

0.575

High

419924

SNF1
Carbon catabolite-derepressing protein kinase

1

7

Small-scale

0.561

High

491803

HSP71
Heat shock protein SSA1

2

4

High-throughput

0.552

High

366580

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.536

High

603001

BAS1
Myb-like DNA-binding protein BAS1

1

1

High-throughput

0.536

High

624131

DBP2
ATP-dependent RNA helicase DBP2

1

5

High-throughput

0.536

High

650337

SPT5
Transcription elongation factor SPT5

1

2

High-throughput

0.536

High

680856

HS104
Heat shock protein 104

1

1

High-throughput

0.536

High

693041

RPD3
Histone deacetylase RPD3

1

9

High-throughput

0.536

High

693331

RPN2
26S proteasome regulatory subunit RPN2

1

2

High-throughput

0.536

High

753884

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.536

High

761263

CAJ1
Protein CAJ1

1

4

High-throughput

0.536

High

837464

RCO1
Transcriptional regulatory protein RCO1

1

13

High-throughput

0.536

High

837472

SUB2
ATP-dependent RNA helicase SUB2

1

4

High-throughput

0.536

High

837475

NEW1
[NU+] prion formation protein 1

1

4

High-throughput

0.536

High

770514

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

12

High-throughput

0.514

High

784388

COPB2
Coatomer subunit beta'

1

10

High-throughput

0.514

High

837445

COPA
Coatomer subunit alpha

1

6

High-throughput

0.514

High

333843

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.513

High

343199

TRP
Tryptophan synthase

1

0

High-throughput

0.513

High

419358

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.513

High

763510

NUP60
Nucleoporin NUP60

1

0

High-throughput

0.513

High

837440

ACS2
Acetyl-coenzyme A synthetase 2

1

0

High-throughput

0.513

High

837449

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.513

High

837469

RRP15
Ribosomal RNA-processing protein 15

1

0

High-throughput

0.513

High

629003

SCJ1
DnaJ-related protein SCJ1

2

4

High-throughput

0.504

High

409661

KAPC
cAMP-dependent protein kinase type 3

1

5

High-throughput

0.501

High

416312

SIR3
Regulatory protein SIR3

1

2

High-throughput

0.489

High

485772

IF4A
ATP-dependent RNA helicase eIF4A

1

6

High-throughput

0.489

High

540239

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

4

High-throughput

0.489

High

541899

NSP1
Nucleoporin NSP1

1

5

High-throughput

0.489

High

544074

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.489

High

561018

EF3A
Elongation factor 3A

1

3

High-throughput

0.489

High

566624

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.489

High

588150

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.489

High

595048

NUP1
Nucleoporin NUP1

1

12

High-throughput

0.489

High

614517

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

4

High-throughput

0.489

High

699797

KPR1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.489

High

730997

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.489

High

744056

SYG
Glycine--tRNA ligase 1, mitochondrial

1

1

High-throughput

0.489

High

752854

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.489

High

760774

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.489

High

765001

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

3

High-throughput

0.489

High

792385

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.489

High

837450

ACAC
Acetyl-CoA carboxylase

1

3

High-throughput

0.489

High

837454

NU116
Nucleoporin NUP116/NSP116

1

3

High-throughput

0.489

High

837474

HRK1
Serine/threonine-protein kinase HRK1

1

5

High-throughput

0.489

High

381616

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

High-throughput

0.486

High

771534

SECU
Securin

1

0

Small-scale

0.480

High

662746

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

697413

CHD1
Chromo domain-containing protein 1

1

9

Small-scale

0.479

High

730857

CENPA
Histone H3-like centromeric protein CSE4

1

8

Small-scale

0.479

High

751051

RCK1
Serine/threonine-protein kinase RCK1

1

5

High-throughput

0.479

High

837448

APJ1
J domain-containing protein APJ1

1

5

High-throughput

0.479

High

837480

YRA1
RNA annealing protein YRA1

1

4

Small-scale

0.479

High

562260

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

2

High-throughput

0.464

High

294143

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.458

High

689911

ASF1
Histone chaperone ASF1

1

0

Small-scale

0.458

High

696743

RTG2
Retrograde regulation protein 2

1

0

Small-scale

0.458

High

716288

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

716467

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

785012

GSHR
Glutathione reductase

1

0

High-throughput

0.458

High

812044

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

334504

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.445

High

423692

ADR1
Regulatory protein ADR1

1

1

High-throughput

0.445

High

429737

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.445

High

440066

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.445

High

450109

HSP73
Heat shock protein SSA3

1

4

High-throughput

0.445

High

472579

YL12B
Transposon Ty1-LR2 Gag-Pol polyprotein

1

2

High-throughput

0.445

High

501176

HSF
Heat shock transcription factor

1

2

High-throughput

0.445

High

511966

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

549063

TRM1
tRNA

1

1

High-throughput

0.445

High

560729

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.445

High

577165

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

5

High-throughput

0.445

High

593164

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.445

High

628263

SIS1
Protein SIS1

1

2

High-throughput

0.445

High

636674

CDC48
Cell division control protein 48

1

4

High-throughput

0.445

High

648397

NSR1
Nuclear localization sequence-binding protein

1

4

High-throughput

0.445

High

679750

PSK1
Serine/threonine-protein kinase PSK1

1

9

High-throughput

0.445

High

695076

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

706975

MSN2
Zinc finger protein MSN2

1

3

High-throughput

0.445

High

707030

MSN4
Zinc finger protein MSN4

1

2

High-throughput

0.445

High

730652

EF1G2
Elongation factor 1-gamma 2

1

3

High-throughput

0.445

High

744151

ATR
Serine/threonine-protein kinase MEC1

1

9

High-throughput

0.445

High

797918

RSC8
Chromatin structure-remodeling complex protein RSC8

1

9

High-throughput

0.445

High

819891

CLA4
Serine/threonine-protein kinase CLA4

1

5

High-throughput

0.445

High

837444

YG5B
Uncharacterized RNA-binding protein YGR250C

1

2

High-throughput

0.445

High

837455

IMA1
Importin subunit alpha

1

4

High-throughput

0.445

High

837461

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.445

High

837479

YG11B
Transposon Ty1-GR1 Gag-Pol polyprotein

1

2

High-throughput

0.445

High

837482

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.445

High

837478

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

2

High-throughput

0.437

High

519526

PDR1
Transcription factor PDR1

1

0

High-throughput

0.426

High

530015

STE12
Protein STE12

1

0

High-throughput

0.426

High

537454

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.426

High

554693

HSP26
Heat shock protein 26

1

0

High-throughput

0.426

High

587316

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.426

High

587867

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.426

High

605237

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

609111

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

634887

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.426

High

837456

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.426

High

837462

PPN1
Endopolyphosphatase

1

0

High-throughput

0.426

High

837468

ECM22
Sterol regulatory element-binding protein ECM22

1

0

High-throughput

0.426

High

837481

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

334957

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.407

High

357528

RLA4
Large ribosomal subunit protein P2B

1

2

High-throughput

0.407

High

360951

TBB
Tubulin beta chain

1

7

High-throughput

0.407

High

399547

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

399769

RLA1
Large ribosomal subunit protein P1A

1

2

High-throughput

0.407

High

399897

RLA2
Large ribosomal subunit protein P2A

1

2

High-throughput

0.407

High

416794

CDC31
Cell division control protein 31

1

7

High-throughput

0.407

High

421663

FAS1
Fatty acid synthase subunit beta

1

3

High-throughput

0.407

High

443943

CYAA
Adenylate cyclase

1

6

High-throughput

0.407

High

446190

MYO1
Myosin-1

1

5

High-throughput

0.407

High

478353

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.407

High

496068

RLA3
Large ribosomal subunit protein P1B

1

2

High-throughput

0.407

High

534798

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.407

High

562411

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

2

High-throughput

0.407

High

604445

CLH
Clathrin heavy chain

1

2

High-throughput

0.407

High

655864

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

2

High-throughput

0.407

High

690950

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

High-throughput

0.407

High

691565

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.407

High

691644

NUP2
Nucleoporin NUP2

1

5

High-throughput

0.407

High

692843

SPT16
FACT complex subunit SPT16

1

3

High-throughput

0.407

High

715822

MDJ1
DnaJ homolog 1, mitochondrial

1

5

High-throughput

0.407

High

761036

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.407

High

772904

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.407

High

811390

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.407

High

837446

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.407

High

837447

NAT10
RNA cytidine acetyltransferase

1

2

High-throughput

0.407

High

837452

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

18

High-throughput

0.407

High

837459

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.407

High

837467

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

7

High-throughput

0.407

High

837473

BRX1
Ribosome biogenesis protein BRX1

1

5

High-throughput

0.407

High

837483

NOP58
Nucleolar protein 58

1

3

High-throughput

0.407

High

837463

RBA50
RNA polymerase II-associated protein RBA50

2

0

High-throughput

0.318

High

402986

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.279

Low

519609

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.279

Low

540119

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.279

Low

657260

URA7
CTP synthase 1

1

0

High-throughput

0.279

Low

837443

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.279

Low

837451

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.279

Low

837465

RTN1
Reticulon-like protein 1

1

0

High-throughput

0.279

Low

837470

CSR1
Phosphatidylinositol transfer protein CSR1

1

0

High-throughput

0.279

Low

389953

VDAC1
Mitochondrial outer membrane protein porin 1

1

0

High-throughput

0.232

Low

420306

CALM
Calmodulin

1

0

High-throughput

0.232

Low

479656

RS30B
Small ribosomal subunit protein eS30B

1

0

High-throughput

0.232

Low

549303

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.232

Low

592946

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.232

Low

599866

DIT1
Spore wall maturation protein DIT1

1

0

High-throughput

0.232

Low

629644

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.232

Low

659121

CAPZA
F-actin-capping protein subunit alpha

1

0

High-throughput

0.232

Low

691750

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

0

High-throughput

0.232

Low

713244

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.232

Low

745047

AP3M
AP-3 complex subunit mu

1

0

High-throughput

0.232

Low

810062

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.232

Low

814702

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.232

Low

837471

MRL1
Mannose 6-phosphate receptor-like protein 1

1

0

High-throughput

0.232

Low

837484

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024