Protein: SYL
Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS)

Gene: SYL, leuS
Organism: Thermococcus kodakarensis KOD1
Interactions: 115
UniProt ID: Q8NKR7

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004823 - leucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006429 - leucyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1205572

SYM
Methionine--tRNA ligase

1

18

High-throughput

0.575

High

1205558

SYC
Cysteine--tRNA ligase

1

10

High-throughput

0.445

High

1205560

Q5JD92
Predicted GTPase, containing TGS domain

1

5

High-throughput

0.445

High

1205575

Q5JE32
DNA-directed RNA polymerase subunit beta

1

1

High-throughput

0.445

High

1205581

Q5JEC3
Predicted DNA methylase

1

1

High-throughput

0.445

High

1205587

Q5JEZ6
non-specific serine/threonine protein kinase

1

1

High-throughput

0.445

High

1205590

SYP
Proline--tRNA ligase

1

12

High-throughput

0.445

High

1205591

SYY
Tyrosine--tRNA ligase

1

4

High-throughput

0.445

High

1205604

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

1205608

PYRG
CTP synthase

1

1

High-throughput

0.445

High

1205616

IF2P
Probable translation initiation factor IF-2 [Cleaved into: Pko infB intein

1

10

High-throughput

0.445

High

1205626

PYRB
Aspartate carbamoyltransferase catalytic subunit

1

6

High-throughput

0.445

High

1205630

PAN
Proteasome-activating nucleotidase

1

3

High-throughput

0.445

High

1205636

Q5JI30
Thiamine-monophosphate kinase

1

1

High-throughput

0.445

High

1205642

SYG
Glycine--tRNA ligase

1

3

High-throughput

0.445

High

1205655

Q5JJ02
Sugar-phosphate nucleotydyltransferase

1

2

High-throughput

0.445

High

1205660

Q5JJB9
NADH:polysulfide oxidoreductase

1

8

High-throughput

0.445

High

1205667

RPO3
DNA-directed RNA polymerase subunit Rpo3

1

5

High-throughput

0.445

High

313514

GLPK
Glycerol kinase

1

0

High-throughput

0.426

High

1197961

THSB
Thermosome subunit beta

1

0

High-throughput

0.426

High

1205568

Q5JDR3
ATPase, RecA superfamily

1

0

High-throughput

0.426

High

1205582

Q5JEM0
Predicted N6-adenine-specific DNA methylase

1

0

High-throughput

0.426

High

1205585

RADA
DNA repair and recombination protein RadA [Cleaved into: Pko RadA intein]

1

0

High-throughput

0.426

High

1205592

Q5JF65
DEAD/DEAH box RNA helicase

1

0

High-throughput

0.426

High

1205598

GUAAB
GMP synthase [glutamine-hydrolyzing] subunit B

1

0

High-throughput

0.426

High

1205601

Q5JFX8
L-aspartate oxidase

1

0

High-throughput

0.426

High

1205602

NADA
Quinolinate synthase

1

0

High-throughput

0.426

High

1205606

PYRH
Uridylate kinase

1

0

High-throughput

0.426

High

1205610

Q5JGH8
lipoate--protein ligase

1

0

High-throughput

0.426

High

1205624

TOP6B
Type 2 DNA topoisomerase 6 subunit B

1

0

High-throughput

0.426

High

1205625

TOP6A
Type 2 DNA topoisomerase 6 subunit A

1

0

High-throughput

0.426

High

1205629

Q5JHS0
Deoxycytidylate deaminase

1

0

High-throughput

0.426

High

1205652

PSA
Proteasome subunit alpha

1

0

High-throughput

0.426

High

1205654

Q5JIY0
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

0

High-throughput

0.426

High

1205658

Q5JJB0
5-methylcytosine restriction system, GTPase subunit

1

0

High-throughput

0.426

High

1205661

Q5JJC7
Isopentenyl phosphate kinase

1

0

High-throughput

0.426

High

1205664

KCY
Cytidylate kinase

1

0

High-throughput

0.426

High

1205671

KADA
Adenylate kinase

1

0

High-throughput

0.426

High

1260502

IDI2
Isopentenyl-diphosphate delta-isomerase

1

0

High-throughput

0.426

High

1341376

FTSZ2
Cell division protein FtsZ 2

1

0

High-throughput

0.426

High

1205563

RS19
Small ribosomal subunit protein uS19

1

2

High-throughput

0.407

High

1205564

RS17
Small ribosomal subunit protein uS17

1

1

High-throughput

0.407

High

1205566

Q5JDI4
Probable serine--glyoxylate aminotransferase, class V

1

2

High-throughput

0.407

High

1205567

RS6E
Small ribosomal subunit protein eS6

1

1

High-throughput

0.407

High

1205573

RS12
Small ribosomal subunit protein uS12

1

3

High-throughput

0.407

High

1205576

RS27
Small ribosomal subunit protein eS27

1

3

High-throughput

0.407

High

1205584

MTAP
S-methyl-5'-thioadenosine phosphorylase

1

1

High-throughput

0.407

High

1205586

ENO
Enolase

1

2

High-throughput

0.407

High

1205594

Q5JFI2
Probable acetylpolyamine aminohydrolase, histon deacetylase family

1

5

High-throughput

0.407

High

1205597

Q5JFK1
Acetyl-CoA acetyltransferase

1

2

High-throughput

0.407

High

1205599

Q5JFM7
Predicted glutamine amidotransferase, class I

1

2

High-throughput

0.407

High

1205603

EF2
Elongation factor 2

1

9

High-throughput

0.407

High

1205605

RS10
Small ribosomal subunit protein uS10

1

3

High-throughput

0.407

High

1205611

RS15
Small ribosomal subunit protein uS15

1

1

High-throughput

0.407

High

1205613

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.407

High

1205614

RS19E
Small ribosomal subunit protein eS19

1

2

High-throughput

0.407

High

1205615

NSR
NAD(P)H sulfur oxidoreductase

1

5

High-throughput

0.407

High

1205618

Q5JGT0
Ferredoxin:NADP oxidoreductase, alpha subunit

1

6

High-throughput

0.407

High

1205627

MOAA
Probable GTP 3',8-cyclase

1

1

High-throughput

0.407

High

1205632

Q5JHY2

1

5

High-throughput

0.407

High

1205633

Q5JHZ0
Type A flavoprotein

1

1

High-throughput

0.407

High

1205634

Q5JI19

1

3

High-throughput

0.407

High

1205639

TRM1
tRNA

1

1

High-throughput

0.407

High

1205641

Q5JID5
tRNA

1

2

High-throughput

0.407

High

1205648

Q5JIJ0
cysteine desulfurase

1

3

High-throughput

0.407

High

1205651

Q5JIR0
Hydrolase, metallo-beta-lactamase superfamily

1

1

High-throughput

0.407

High

1205659

PNPH
Probable 6-oxopurine nucleoside phosphorylase

1

1

High-throughput

0.407

High

1205662

RS2
Small ribosomal subunit protein uS2

1

5

High-throughput

0.407

High

1205663

RS9
Small ribosomal subunit protein uS9

1

2

High-throughput

0.407

High

1205666

RS11
Small ribosomal subunit protein uS11

1

3

High-throughput

0.407

High

1205669

RS8
Small ribosomal subunit protein uS8

1

3

High-throughput

0.407

High

1205670

RS5
Small ribosomal subunit protein uS5

1

1

High-throughput

0.407

High

313515

RBL
Ribulose bisphosphate carboxylase

1

0

High-throughput

0.232

Low

1205557

MOAC
Probable cyclic pyranopterin monophosphate synthase

1

0

High-throughput

0.232

Low

1205559

Q5JD73
Bifunctional carboxypeptidase/aminoacylase

1

0

High-throughput

0.232

Low

1205561

Q5JD97
Aspartate racemase

1

0

High-throughput

0.232

Low

1205562

Q5JDE3
Iron-molybdenum cofactor-binding protein

1

0

High-throughput

0.232

Low

1205565

Q5JDI3
Predicetd ATPase

1

0

High-throughput

0.232

Low

1205569

Q5JDW4
D-aminopeptidase

1

0

High-throughput

0.232

Low

1205570

Q5JDX0
Metallophosphoesterase, calcineurin superfamily

1

0

High-throughput

0.232

Low

1205571

Q5JDZ0
Rubrerythrin-related protein

1

0

High-throughput

0.232

Low

1205574

Q5JE30
Protein disulfide oxidoreductase

1

0

High-throughput

0.232

Low

1205577

Q5JE59
2-oxoglutarate synthase subunit KorA

1

0

High-throughput

0.232

Low

1205578

Q5JE61
2-oxoacid:ferredoxin oxidoreductases, gamma subunit

1

0

High-throughput

0.232

Low

1205579

RNZ
Ribonuclease Z

1

0

High-throughput

0.232

Low

1205580

Q5JE90
Predicted AP endonuclease

1

0

High-throughput

0.232

Low

1205583

Q5JEN6
Transcription regulator, ArsR family

1

0

High-throughput

0.232

Low

1205589

Q5JF43
Putative methylthioribose-1-phosphate isomerase

1

0

High-throughput

0.232

Low

1205595

PDAD
Pyruvoyl-dependent arginine decarboxylase

1

0

High-throughput

0.232

Low

1205596

Q5JFJ4
RecJ-like exonuclease, containing OB-fold nucleic acid-binding domains

1

0

High-throughput

0.232

Low

1205600

PDXS
Pyridoxal 5'-phosphate synthase subunit PdxS

1

0

High-throughput

0.232

Low

1205607

Q5JG60
SAM-dependent methyltransferase, UbiE/COQ5 family

1

0

High-throughput

0.232

Low

1205609

Q5JGH2
Phospholipid-binding protein, PBP family

1

0

High-throughput

0.232

Low

1205612

RF1
Peptide chain release factor subunit 1

1

0

High-throughput

0.232

Low

1205617

Q5JGS9
Ferredoxin:NADP oxidoreductase, beta subunit

1

0

High-throughput

0.232

Low

1205619

Q5JGT9
Predicted transcription regulator, Lrp/AsnC family

1

0

High-throughput

0.232

Low

1205620

GCSPB
Probable glycine dehydrogenase

1

0

High-throughput

0.232

Low

1205621

RPIA
Ribose-5-phosphate isomerase A

1

0

High-throughput

0.232

Low

1205622

Q5JH40
Probable phosphate transport system regulator, fused to TrkA-C domain

1

0

High-throughput

0.232

Low

1205623

MPTA
GTP cyclohydrolase MptA

1

0

High-throughput

0.232

Low

1205628

Q5JHP7
DNA helicase

1

0

High-throughput

0.232

Low

1205631

Q5JHV9
4Fe-4S cluster-binding protein

1

0

High-throughput

0.232

Low

1205635

APGM
2,3-bisphosphoglycerate-independent phosphoglycerate mutase

1

0

High-throughput

0.232

Low

1205637

Q5JI60
Pyruvate fromate-lyase activating enzyme-related protein, radical SAM superfamily

1

0

High-throughput

0.232

Low

1205638

Q5JI71
3-hydroxy-3-methylglutaryl coenzyme A reductase

1

0

High-throughput

0.232

Low

1205643

Q5JIG4
Methylmalonyl-CoA mutase, N-terminus of large subunit

1

0

High-throughput

0.232

Low

1205646

Q5JII4
Carbamoyltransferase

1

0

High-throughput

0.232

Low

1205649

Q5JIJ6
Pyruvate:ferredoxin oxidoreductase, beta subunit

1

0

High-throughput

0.232

Low

1205650

Q5JIQ4
Predicted metal-dependent hydrolase

1

0

High-throughput

0.232

Low

1205653

SDO1
Ribosome maturation protein SDO1 homolog

1

0

High-throughput

0.232

Low

1205656

Q5JJ28
Cytidylyltransferase

1

0

High-throughput

0.232

Low

1205657

Q5JJ60
Predicted transcription regulator, DUF118 helix-turn-helix family

1

0

High-throughput

0.232

Low

1205665

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.232

Low

1205668

RS4E
Small ribosomal subunit protein eS4

1

0

High-throughput

0.232

Low

1341377

FLAB1
Flagellin B1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025