Protein: AFG3
Mitochondrial inner membrane m-AAA protease component YTA10 (EC 3.4.24.-) (EC 3.6.-.-) (ATPase family gene 3 protein) (Tat-binding homolog 10)

Gene: AFG3
Organism: Saccharomyces cerevisiae S288C
Interactions: 61
UniProt ID: P39925

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

764770

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

9

10

Small-scale

0.965

High

764773

PHB1
Prohibitin-1

5

10

Small-scale

0.709

High

764776

PHB2
Prohibitin-2

3

10

Small-scale

0.656

High

698206

YME1
Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1

1

11

Small-scale

0.618

High

705205

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.618

High

543780

HSC82
ATP-dependent molecular chaperone HSC82

2

6

High-throughput

0.594

High

764775

TOM22
Mitochondrial import receptor subunit TOM22

2

2

High-throughput

0.584

High

629855

RM32
Large ribosomal subunit protein bL32m

2

0

Small-scale

0.576

High

478221

HSP77
Import motor subunit, mitochondrial

2

6

High-throughput

0.571

High

756497

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.552

High

452998

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

389394

HXKB
Hexokinase-2

1

3

High-throughput

0.500

High

511400

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.500

High

556070

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.500

High

560670

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.500

High

570697

HXKG
Glucokinase-1

1

3

High-throughput

0.500

High

588093

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.500

High

693794

CBS
Cystathionine beta-synthase

1

2

High-throughput

0.500

High

764784

GET3
ATPase GET3

1

0

High-throughput

0.486

High

404341

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.479

High

520985

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

333378

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

1

High-throughput

0.479

High

333436

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

1

High-throughput

0.479

High

335949

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.479

High

336051

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.479

High

336139

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

1

High-throughput

0.479

High

357283

RMAR
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.479

High

373252

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

389917

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.479

High

404064

ATPF
ATP synthase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

424087

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

5

High-throughput

0.479

High

424205

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

5

High-throughput

0.479

High

435466

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.479

High

440185

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

1

1

High-throughput

0.479

High

619738

TOM40
Mitochondrial import receptor subunit TOM40

1

3

High-throughput

0.479

High

634286

MGR1
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1

1

1

Small-scale

0.479

High

699635

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.479

High

699895

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

2

High-throughput

0.479

High

732903

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

764769

OXA1
Mitochondrial inner membrane protein OXA1

1

3

High-throughput

0.479

High

764771

PUP1
PUP1 protein homolog

1

1

High-throughput

0.479

High

764777

MCY1
Putative mitochondrial cysteine synthase

1

2

High-throughput

0.479

High

764778

RCF2
Respiratory supercomplex factor 2, mitochondrial

1

1

High-throughput

0.479

High

764780

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

764781

MGR3
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3

1

1

Small-scale

0.479

High

764782

ATG33
Autophagy-related protein 33

1

1

High-throughput

0.479

High

450607

ATPO
ATP synthase subunit 5, mitochondrial

1

0

High-throughput

0.458

High

698311

COX13
Cytochrome c oxidase subunit 13, mitochondrial

1

0

High-throughput

0.458

High

366329

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.445

High

764772

DJP1
DnaJ-like protein 1

1

3

High-throughput

0.445

High

764774

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.445

High

764779

JJJ1
J protein JJJ1

1

7

High-throughput

0.445

High

700908

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

745666

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

520341

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

2

High-throughput

0.407

High

764783

UTP4
U3 small nucleolar RNA-associated protein 4

1

1

High-throughput

0.407

High

748613

ENP1
Essential nuclear protein 1

1

0

High-throughput

0.279

Low

381707

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low

411007

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.261

Low

699341

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.261

Low

612235

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024