Protein: UBC4
Ubiquitin-conjugating enzyme E2 4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 4) (Ubiquitin carrier protein 4) (Ubiquitin-protein ligase 4)

Gene: UBC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 84
UniProt ID: P15731

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

549847

APC11
Anaphase-promoting complex subunit 11

21

20

Small-scale

0.988

High

549815

RSP5
E3 ubiquitin-protein ligase RSP5

16

20

Small-scale

0.985

High

549803

NOT4
General negative regulator of transcription subunit 4

8

11

Small-scale

0.967

High

549835

HEL2
E3 ubiquitin-protein ligase HEL2

5

3

Small-scale

0.927

High

549801

UFD4
Ubiquitin fusion degradation protein 4

5

20

Small-scale

0.924

High

549788

UBA1
Ubiquitin-activating enzyme E1 1

4

20

Small-scale

0.888

High

549807

TUL1
Transmembrane E3 ubiquitin-protein ligase 1

3

2

Small-scale

0.868

High

549817

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

3

1

Small-scale

0.845

High

549825

CDH1
APC/C activator protein CDH1

3

12

Small-scale

0.845

High

549782

UBC4
Ubiquitin-conjugating enzyme E2 4

3

16

Small-scale

0.840

High

549834

PEX10
Peroxisome biogenesis factor 10

2

20

Small-scale

0.778

High

549837

PIB1
E3 ubiquitin-protein ligase PIB1

2

3

Small-scale

0.778

High

549841

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

2

20

Small-scale

0.778

High

549843

RBX1
RING-box protein HRT1

2

20

Small-scale

0.778

High

549783

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

2

17

Small-scale

0.776

High

549808

HEL1
E3 ubiquitin-protein ligase HEL1

1

20

Small-scale

0.724

High

549799

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

4

1

Small-scale

0.686

High

477103

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

549827

UFD2
E4 ubiquitin-protein ligase UFD2

1

20

Small-scale

0.647

High

549836

MAG2
E3 ubiquitin-protein ligase MAG2

1

20

Small-scale

0.647

High

543118

HSC82
ATP-dependent molecular chaperone HSC82

3

3

High-throughput

0.640

High

549790

RS5
Small ribosomal subunit protein uS7

3

0

Small-scale

0.627

High

549798

PEX2
Peroxisomal biogenesis factor 2

3

0

Small-scale

0.623

High

549823

HUL5
E3 ubiquitin-protein ligase HUL5

1

20

Small-scale

0.618

High

549811

DMA1
E3 ubiquitin-protein ligase DMA1

2

2

Small-scale

0.602

High

549786

PSB4
Proteasome subunit beta type-4

2

5

Small-scale

0.571

High

522434

PEP5
E3 ubiquitin-protein ligase PEP5

1

1

Small-scale

0.561

High

549824

SNT2
E3 ubiquitin-protein ligase SNT2

1

1

Small-scale

0.561

High

549810

RPN1
26S proteasome regulatory subunit RPN1

1

0

Small-scale

0.527

High

549812

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

Small-scale

0.508

High

549830

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

2

Small-scale

0.508

High

549795

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

3

Small-scale

0.501

High

549813

RPN10
26S proteasome regulatory subunit RPN10

1

1

Small-scale

0.501

High

549826

DMA2
E3 ubiquitin-protein ligase DMA2

1

2

Small-scale

0.501

High

549829

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

Small-scale

0.501

High

549832

PEX12
Peroxisome assembly protein 12

1

1

Small-scale

0.501

High

549805

MPE1
Protein MPE1

1

0

Small-scale

0.480

High

549814

POP2
Poly(A) ribonuclease POP2

1

0

Small-scale

0.480

High

381417

GAL1
Galactokinase

1

0

High-throughput

0.479

High

549842

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

365722

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.479

High

485628

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.479

High

514953

RNA1
Ran GTPase-activating protein 1

1

2

High-throughput

0.479

High

549787

RAD53
Serine/threonine-protein kinase RAD53

1

1

Small-scale

0.479

High

549804

PEX5
Peroxisomal targeting signal receptor

1

1

Small-scale

0.479

High

549819

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

4

High-throughput

0.479

High

549820

CUL8
Cullin-8

1

17

Small-scale

0.479

High

549828

H3
Histone H3

1

3

Small-scale

0.479

High

549839

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.479

High

549840

SUB2
ATP-dependent RNA helicase SUB2

1

2

High-throughput

0.479

High

549844

ULS1
ATP-dependent helicase ULS1

1

12

Small-scale

0.479

High

549797

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.460

High

549816

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

406746

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

482052

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

549784

CCA1
CCA tRNA nucleotidyltransferase, mitochondrial

1

0

High-throughput

0.458

High

549789

NOT1
General negative regulator of transcription subunit 1

1

0

High-throughput

0.458

High

549792

URA7
CTP synthase 1

1

0

High-throughput

0.458

High

549793

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

549796

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

549809

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

549821

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.458

High

549822

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

549848

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.458

High

493108

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

549794

PSB5
Proteasome subunit beta type-5

1

4

Small-scale

0.445

High

549818

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

357855

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

470831

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

549791

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

549806

YKT6
Synaptobrevin homolog YKT6

1

1

High-throughput

0.437

High

549845

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

333414

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

0

High-throughput

0.279

Low

549846

RRS1
Regulator of ribosome biosynthesis

1

0

High-throughput

0.269

Low

549831

TFB3
RNA polymerase II transcription factor B subunit 3

1

0

Small-scale

0.261

Low

549833

SSL1
General transcription and DNA repair factor IIH subunit SSL1

1

0

Small-scale

0.261

Low

520777

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.261

Low

549785

CLH
Clathrin heavy chain

1

0

High-throughput

0.261

Low

405397

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

413275

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

549800

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

549802

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

549838

NVJ2
Nucleus-vacuole junction protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024