Protein: SPT8
Transcription factor SPT8

Gene: SPT8
Organism: Saccharomyces cerevisiae S288C
Interactions: 208
UniProt ID: P38915

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000124 - SAGA complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006325 - chromatin organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

715326

SPT7
Transcriptional activator SPT7

19

2

Small-scale

0.764

High

757456

ADA2
Transcriptional adapter 2

14

1

Small-scale

0.761

High

757481

HFI1
Transcriptional coactivator HFI1/ADA1

9

1

Small-scale

0.753

High

755416

TRA1
Transcription-associated protein 1

8

1

Small-scale

0.750

High

757442

TAF6
Transcription initiation factor TFIID subunit 6

13

0

Small-scale

0.728

High

757441

SPT20
Transcription factor SPT20

12

0

Small-scale

0.727

High

757459

GCN5
Histone acetyltransferase GCN5

11

0

Small-scale

0.725

High

744615

TAF5
Transcription initiation factor TFIID subunit 5

11

0

Small-scale

0.723

High

757439

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

11

0

Small-scale

0.723

High

691319

NGG1
Chromatin-remodeling complexes subunit NGG1

8

0

Small-scale

0.720

High

757462

TAF12
Transcription initiation factor TFIID subunit 12

8

0

Small-scale

0.717

High

420610

SPT3
Protein SPT3

7

0

Small-scale

0.714

High

757458

SGF11
SAGA-associated factor 11

7

0

Small-scale

0.712

High

757480

TAF10
Transcription initiation factor TFIID subunit 10

7

0

Small-scale

0.709

High

633860

SGF29
SAGA-associated factor 29

6

0

Small-scale

0.702

High

757445

SGF73
SAGA-associated factor 73

6

0

Small-scale

0.702

High

757490

SUS1
Transcription and mRNA export factor SUS1

6

0

Small-scale

0.702

High

757468

TAF9
Transcription initiation factor TFIID subunit 9

6

0

Small-scale

0.701

High

527005

TBP
TATA-box-binding protein

5

0

Small-scale

0.688

High

757463

RUVB1
RuvB-like protein 1

2

1

High-throughput

0.611

High

425469

TFS2
Transcription elongation factor S-II

2

0

Small-scale

0.593

High

423682

ADR1
Regulatory protein ADR1

2

0

High-throughput

0.576

High

598573

PRP5
Pre-mRNA-processing ATP-dependent RNA helicase PRP5

1

1

Small-scale

0.561

High

757434

TAF1
Transcription initiation factor TFIID subunit 1

2

0

Small-scale

0.560

High

687696

BTAF1
TATA-binding protein-associated factor MOT1

2

0

Small-scale

0.559

High

334479

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.536

High

375386

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.536

High

703798

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.536

High

753802

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.536

High

757425

PRS4
26S proteasome regulatory subunit 4 homolog

1

2

High-throughput

0.536

High

757438

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.536

High

757482

YG11B
Transposon Ty1-GR1 Gag-Pol polyprotein

1

1

High-throughput

0.536

High

757487

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.536

High

614499

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

2

1

Small-scale

0.534

High

440033

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

501169

HSF
Heat shock transcription factor

1

0

High-throughput

0.513

High

703616

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.513

High

757411

SPT8
Transcription factor SPT8

1

0

High-throughput

0.513

High

757475

PUF3
mRNA-binding protein PUF3

1

0

High-throughput

0.513

High

630997

KCC4
Probable serine/threonine-protein kinase KCC4

1

1

High-throughput

0.501

High

752114

KSP1
Serine/threonine-protein kinase KSP1

1

1

High-throughput

0.501

High

334932

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.489

High

519938

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.489

High

566581

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.489

High

757414

TCPB
T-complex protein 1 subunit beta

1

3

High-throughput

0.489

High

757415

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.489

High

757426

TCPE
T-complex protein 1 subunit epsilon

1

3

High-throughput

0.489

High

757431

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.489

High

757435

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.489

High

701873

SWE1
Mitosis inhibitor protein kinase SWE1

1

0

High-throughput

0.480

High

757413

IPL1
Spindle assembly checkpoint kinase

1

0

High-throughput

0.480

High

757440

TAF4
Transcription initiation factor TFIID subunit 4

1

0

Small-scale

0.480

High

586305

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.460

High

419880

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.458

High

662207

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

691046

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.458

High

698801

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

751021

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

757464

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

757470

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

757483

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

757489

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.458

High

540229

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

1

Small-scale

0.457

High

416782

CDC31
Cell division control protein 31

1

1

High-throughput

0.445

High

450045

HSP73
Heat shock protein SSA3

1

2

High-throughput

0.445

High

472574

YL12B
Transposon Ty1-LR2 Gag-Pol polyprotein

1

1

High-throughput

0.445

High

491209

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

493953

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

501368

RPA1
DNA-directed RNA polymerase I subunit RPA190

1

1

High-throughput

0.445

High

511294

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

554642

HSP26
Heat shock protein 26

1

1

High-throughput

0.445

High

693300

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.445

High

696143

SWI3
SWI/SNF complex subunit SWI3

1

1

High-throughput

0.445

High

706963

MSN2
Zinc finger protein MSN2

1

1

High-throughput

0.445

High

707019

MSN4
Zinc finger protein MSN4

1

1

High-throughput

0.445

High

754409

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

757455

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

High-throughput

0.445

High

757479

NEW1
[NU+] prion formation protein 1

1

1

High-throughput

0.445

High

757476

SDO1
Ribosome maturation protein SDO1

1

0

High-throughput

0.438

High

730695

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.437

High

343191

TRP
Tryptophan synthase

1

0

High-throughput

0.426

High

408358

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.426

High

419337

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.426

High

429698

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.426

High

530009

STE12
Protein STE12

1

0

High-throughput

0.426

High

549050

TRM1
tRNA

1

0

High-throughput

0.426

High

560657

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.426

High

577153

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

High-throughput

0.426

High

587852

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.426

High

605230

AFT1
Iron-regulated transcriptional activator AFT1

1

0

High-throughput

0.426

High

608465

SAN1
Protein SAN1

1

0

High-throughput

0.426

High

609086

SIN3
Transcriptional regulatory protein SIN3

1

0

High-throughput

0.426

High

613854

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.426

High

624085

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.426

High

627616

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.426

High

628866

SWI4
Regulatory protein SWI4

1

0

High-throughput

0.426

High

634878

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.426

High

636019

AHC2
ADA histone acetyltransferase complex component 2

1

0

High-throughput

0.426

High

636621

CDC48
Cell division control protein 48

1

0

High-throughput

0.426

High

648377

NSR1
Nuclear localization sequence-binding protein

1

0

High-throughput

0.426

High

649958

BUD14
Bud site selection protein 14

1

0

High-throughput

0.426

High

650292

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.426

High

679740

PSK1
Serine/threonine-protein kinase PSK1

1

0

High-throughput

0.426

High

692783

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.426

High

693012

RPD3
Histone deacetylase RPD3

1

0

High-throughput

0.426

High

712916

BMH2
Protein BMH2

1

0

High-throughput

0.426

High

730628

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.426

High

733217

SA190
SIT4-associating protein SAP190

1

0

High-throughput

0.426

High

742792

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.426

High

757419

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.426

High

757422

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.426

High

757423

MIT1
Transcriptional regulator MIT1

1

0

High-throughput

0.426

High

757443

MCM6
DNA replication licensing factor MCM6

1

0

High-throughput

0.426

High

757444

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

0

High-throughput

0.426

High

757449

H3
Histone H3

1

0

High-throughput

0.426

High

757451

REG1
Resistance to glucose repression protein 1

1

0

High-throughput

0.426

High

757453

NOP3
Serine/arginine

1

0

High-throughput

0.426

High

757457

NOG1
Nucleolar GTP-binding protein 1

1

0

High-throughput

0.426

High

757465

PPN1
Endopolyphosphatase

1

0

High-throughput

0.426

High

757467

ERB1
Ribosome biogenesis protein ERB1

1

0

High-throughput

0.426

High

757471

ELP1
Elongator complex protein 1

1

0

High-throughput

0.426

High

757477

RSC58
Chromatin structure-remodeling complex protein RSC58

1

0

High-throughput

0.426

High

757484

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.426

High

399751

RLA1
Large ribosomal subunit protein P1A

1

1

High-throughput

0.407

High

485729

IF4A
ATP-dependent RNA helicase eIF4A

1

1

High-throughput

0.407

High

496044

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.407

High

560973

EF3A
Elongation factor 3A

1

1

High-throughput

0.407

High

578535

SEC18
Vesicular-fusion protein SEC18

1

1

High-throughput

0.407

High

630801

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.407

High

660911

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

1

High-throughput

0.407

High

691742

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.407

High

757416

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.407

High

757427

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.407

High

757429

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.407

High

757430

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

757447

COPA
Coatomer subunit alpha

1

1

High-throughput

0.407

High

757452

ACAC
Acetyl-CoA carboxylase

1

1

High-throughput

0.407

High

757485

HSP42
Heat shock protein 42

1

1

High-throughput

0.407

High

360873

TBB
Tubulin beta chain

1

0

High-throughput

0.279

Low

399875

RLA2
Large ribosomal subunit protein P2A

1

0

High-throughput

0.279

Low

410795

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.279

Low

421637

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.279

Low

537413

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.279

Low

540091

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.279

Low

543721

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.279

Low

562382

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.279

Low

599865

DIT1
Spore wall maturation protein DIT1

1

0

High-throughput

0.279

Low

696789

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.279

Low

699785

KPR1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.279

Low

715795

MDJ1
DnaJ homolog 1, mitochondrial

1

0

High-throughput

0.279

Low

757417

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.279

Low

757418

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.279

Low

757461

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.279

Low

757486

SFI1
Protein SFI1

1

0

High-throughput

0.279

Low

757466

PDR15
ATP-dependent permease PDR15

1

0

High-throughput

0.269

Low

757432

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.261

Low

381704

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

Small-scale

0.249

Low

443979

CISY2
Citrate synthase, peroxisomal

1

0

Small-scale

0.249

Low

700890

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

757412

ASPG1
L-asparaginase 1

1

0

High-throughput

0.249

Low

757436

MTNB
Methylthioribulose-1-phosphate dehydratase

1

0

High-throughput

0.249

Low

757460

YMO7
Uncharacterized protein YMR007W

1

0

High-throughput

0.249

Low

757474

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

333784

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

399465

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

402948

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.232

Low

420282

CALM
Calmodulin

1

0

High-throughput

0.232

Low

424516

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

440885

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

1

0

High-throughput

0.232

Low

446158

MYO1
Myosin-1

1

0

High-throughput

0.232

Low

478187

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.232

Low

519591

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.232

Low

534765

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.232

Low

541877

NSP1
Nucleoporin NSP1

1

0

High-throughput

0.232

Low

549296

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.232

Low

556040

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

568317

CAP
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

572041

CLC1
Clathrin light chain

1

0

High-throughput

0.232

Low

585313

MYO2
Myosin-2

1

0

High-throughput

0.232

Low

588075

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

604409

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

657238

URA7
CTP synthase 1

1

0

High-throughput

0.232

Low

687375

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

689339

ARP2
Actin-related protein 2

1

0

High-throughput

0.232

Low

690926

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

0

High-throughput

0.232

Low

691542

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.232

Low

691797

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.232

Low

713222

TSA1
Peroxiredoxin TSA1

1

0

High-throughput

0.232

Low

730976

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

744041

SYG
Glycine--tRNA ligase 1, mitochondrial

1

0

High-throughput

0.232

Low

745380

SEA4
SEH-associated protein 4

1

0

High-throughput

0.232

Low

752826

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.232

Low

757420

BEM2
GTPase-activating protein BEM2/IPL2

1

0

High-throughput

0.232

Low

757421

DPO5
rDNA transcriptional regulator POL5

1

0

High-throughput

0.232

Low

757424

GLE2
mRNA export factor GLE2

1

0

High-throughput

0.232

Low

757428

COPB
Coatomer subunit beta

1

0

High-throughput

0.232

Low

757433

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.232

Low

757437

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.232

Low

757446

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.232

Low

757448

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.232

Low

757450

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.232

Low

757454

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.232

Low

757469

NGK1
N-acetylglucosamine kinase

1

0

High-throughput

0.232

Low

757472

MRL1
Mannose 6-phosphate receptor-like protein 1

1

0

High-throughput

0.232

Low

757473

YD073
UPF0592 protein YDL073W

1

0

High-throughput

0.232

Low

757478

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

0

High-throughput

0.232

Low

757488

NOP58
Nucleolar protein 58

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024