Protein: HXKA
Hexokinase-1 (EC 2.7.1.1) (Hexokinase PI) (Hexokinase-A)

Gene: HXKA, HXK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 189
UniProt ID: P04806

Gene Ontology (top 5):
GO:0001678 - intracellular glucose homeostasis
GO:0004340 - glucokinase activity
GO:0004396 - hexokinase activity
GO:0005524 - ATP binding
GO:0005536 - D-glucose binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

389179

HXKB
Hexokinase-2

3

12

High-throughput

0.836

High

389178

HXKA
Hexokinase-1

3

12

Small-scale

0.821

High

389212

HSC82
ATP-dependent molecular chaperone HSC82

3

7

High-throughput

0.633

High

389267

TCTP
Translationally-controlled tumor protein homolog

2

2

High-throughput

0.594

High

389250

HS104
Heat shock protein 104

2

5

Small-scale

0.584

High

389201

HSP71
Heat shock protein SSA1

2

10

High-throughput

0.571

High

389326

TRM82
tRNA

1

1

High-throughput

0.515

High

339318

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.500

High

389180

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.500

High

389183

KAPC
cAMP-dependent protein kinase type 3

1

4

High-throughput

0.500

High

389188

SNF1
Carbon catabolite-derepressing protein kinase

1

1

High-throughput

0.500

High

389196

PBS2
MAP kinase kinase PBS2

1

3

High-throughput

0.500

High

389209

KSS1
Mitogen-activated protein kinase KSS1

1

3

High-throughput

0.500

High

389219

FKBP
FK506-binding protein 1

1

1

High-throughput

0.500

High

389220

PP11
Serine/threonine-protein phosphatase PP1-1

1

1

High-throughput

0.500

High

389223

DBF2
Cell cycle protein kinase DBF2

1

3

High-throughput

0.500

High

389226

KC11
Casein kinase I homolog 1

1

5

High-throughput

0.500

High

389227

KC12
Casein kinase I homolog 2

1

4

High-throughput

0.500

High

389231

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.500

High

389239

CDC48
Cell division control protein 48

1

1

High-throughput

0.500

High

389245

HRR25
Casein kinase I homolog HRR25

1

2

High-throughput

0.500

High

389248

RAD16
DNA repair protein RAD16

1

2

High-throughput

0.500

High

389249

PSK1
Serine/threonine-protein kinase PSK1

1

1

High-throughput

0.500

High

389251

DBF20
Serine/threonine-protein kinase DBF20

1

4

High-throughput

0.500

High

389252

KNS1
Dual specificity protein kinase KNS1

1

2

High-throughput

0.500

High

389253

ARP2
Actin-related protein 2

1

2

High-throughput

0.500

High

389255

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.500

High

389256

PP12
Serine/threonine-protein phosphatase PP1-2

1

4

High-throughput

0.500

High

389257

GYP6
GTPase-activating protein GYP6

1

1

High-throughput

0.500

High

389258

KU70
ATP-dependent DNA helicase II subunit 1

1

1

High-throughput

0.500

High

389259

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.500

High

389269

YPT10
GTP-binding protein YPT10

1

4

High-throughput

0.500

High

389271

PLPHP
Pyridoxal phosphate homeostasis protein

1

1

High-throughput

0.500

High

389273

IMB2
Importin subunit beta-2

1

1

High-throughput

0.500

High

389274

SHE3
SWI5-dependent HO expression protein 3

1

1

High-throughput

0.500

High

389275

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

4

High-throughput

0.500

High

389277

RCK2
Serine/threonine-protein kinase RCK2

1

4

High-throughput

0.500

High

389283

DUN1
DNA damage response protein kinase DUN1

1

5

High-throughput

0.500

High

389284

MET30
F-box protein MET30

1

2

High-throughput

0.500

High

389287

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.500

High

389293

TBP6
Probable 26S proteasome subunit YTA6

1

3

High-throughput

0.500

High

389296

AIR1
Protein AIR1

1

1

High-throughput

0.500

High

389300

SKP2
F-box protein SKP2

1

1

High-throughput

0.500

High

389301

MOB2
CBK1 kinase activator protein MOB2

1

1

High-throughput

0.500

High

389304

TOS3
Serine/threonine-protein kinase TOS3

1

1

High-throughput

0.500

High

389309

PPT1
Serine/threonine-protein phosphatase T

1

6

High-throughput

0.500

High

389313

CWC22
Pre-mRNA-splicing factor CWC22

1

1

High-throughput

0.500

High

389315

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.500

High

389316

SIW14
Inositol phosphatase SIW14

1

2

High-throughput

0.500

High

389319

2ABA
Protein phosphatase PP2A regulatory subunit B

1

1

High-throughput

0.500

High

389320

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

3

High-throughput

0.500

High

389324

TDA1
Serine/threonine-protein kinase TDA1

1

3

High-throughput

0.500

High

389336

MLH3
DNA mismatch repair protein MLH3

1

1

High-throughput

0.500

High

389339

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

4

High-throughput

0.500

High

389340

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.500

High

389343

ATG5
Autophagy protein 5

1

2

High-throughput

0.500

High

389346

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.500

High

389221

ACE2
Metallothionein expression activator

1

0

High-throughput

0.493

High

389329

KYNU
Kynureninase

1

0

High-throughput

0.493

High

389337

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.493

High

389345

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.481

High

372752

PYRF
Orotidine 5'-phosphate decarboxylase

1

0

High-throughput

0.479

High

389190

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.479

High

389203

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

0

High-throughput

0.479

High

389224

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.479

High

389233

RAD57
DNA repair protein RAD57

1

0

High-throughput

0.479

High

389238

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.479

High

389260

RAD54
DNA repair and recombination protein RAD54

1

0

High-throughput

0.479

High

389261

UBC6
Ubiquitin-conjugating enzyme E2 6

1

0

High-throughput

0.479

High

389272

LSM2
U6 snRNA-associated Sm-like protein LSm2

1

0

High-throughput

0.479

High

389280

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.479

High

389294

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.479

High

389297

PSMD9
Probable 26S proteasome regulatory subunit p27

1

0

High-throughput

0.479

High

389310

SNT2
E3 ubiquitin-protein ligase SNT2

1

0

High-throughput

0.479

High

389314

PAP2
Poly(A) RNA polymerase protein 2

1

0

High-throughput

0.479

High

389341

RPN5
26S proteasome regulatory subunit RPN5

1

0

High-throughput

0.479

High

389342

WTM1
Transcriptional modulator WTM1

1

0

High-throughput

0.479

High

389344

LAS17
Proline-rich protein LAS17

1

0

High-throughput

0.479

High

334395

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

3

High-throughput

0.479

High

334570

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

3

High-throughput

0.479

High

334856

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

3

High-throughput

0.479

High

336646

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.479

High

339949

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.479

High

340570

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

342604

ENO1
Enolase 1

1

5

High-throughput

0.479

High

342802

ENO2
Enolase 2

1

5

High-throughput

0.479

High

343478

PMG1
Phosphoglycerate mutase 1

1

4

High-throughput

0.479

High

365518

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.479

High

382825

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

389186

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

389197

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

389198

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

389199

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

389200

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

4

High-throughput

0.479

High

389206

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.479

High

389208

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.479

High

389211

TAL1
Transaldolase

1

1

High-throughput

0.479

High

389213

STI1
Heat shock protein STI1

1

1

High-throughput

0.479

High

389222

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

389232

SIS1
Protein SIS1

1

5

High-throughput

0.479

High

389236

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

389268

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

389285

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

389288

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

389292

MMF1
Protein MMF1, mitochondrial

1

1

High-throughput

0.479

High

389302

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

2

High-throughput

0.479

High

389312

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

389317

SAM50
Sorting assembly machinery 50 kDa subunit

1

2

High-throughput

0.479

High

389321

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

389322

COFI
Cofilin

1

1

High-throughput

0.479

High

389333

ZEO1
Protein ZEO1

1

1

High-throughput

0.479

High

337155

HIS1
ATP phosphoribosyltransferase

1

0

High-throughput

0.458

High

341692

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

341745

IPYR
Inorganic pyrophosphatase

1

0

Small-scale

0.458

High

343320

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

357144

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

389181

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

389182

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

389184

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

389185

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

389191

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

389192

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

389193

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

389194

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

389207

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.458

High

389210

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

389215

THRC
Threonine synthase

1

0

High-throughput

0.458

High

389225

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

389228

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.458

High

389243

AROC
Chorismate synthase ARO2

1

0

High-throughput

0.458

High

389246

TRXB1
Thioredoxin reductase 1

1

0

High-throughput

0.458

High

389247

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.458

High

389254

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

389264

TSA1
Peroxiredoxin TSA1

1

0

Small-scale

0.458

High

389278

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.458

High

389281

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

389289

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

389298

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

389303

DUG1
Cys-Gly metallodipeptidase DUG1

1

0

High-throughput

0.458

High

389305

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

389306

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.458

High

389318

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.458

High

389323

VPS60
Vacuolar protein-sorting-associated protein 60

1

0

Small-scale

0.458

High

389325

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

389328

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

389187

HAP2
Transcriptional activator HAP2

1

1

High-throughput

0.457

High

389214

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.457

High

389218

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.457

High

389234

CDC10
Cell division control protein 10

1

2

High-throughput

0.457

High

389241

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

389282

TEM1
Protein TEM1

1

4

High-throughput

0.457

High

389286

SWD1
COMPASS component SWD1

1

3

High-throughput

0.457

High

389299

PFS2
Polyadenylation factor subunit 2

1

1

High-throughput

0.457

High

389307

SEH1
Nucleoporin SEH1

1

2

High-throughput

0.457

High

389327

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

389332

RRP9
Ribosomal RNA-processing protein 9

1

2

High-throughput

0.457

High

389202

HSP72
Heat shock protein SSA2

1

10

High-throughput

0.445

High

389204

SSB1
Ribosome-associated molecular chaperone SSB1

1

11

High-throughput

0.445

High

389262

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

389291

SSB2
Ribosome-associated molecular chaperone SSB2

1

11

High-throughput

0.445

High

389311

THG1
tRNA(His) guanylyltransferase

1

0

High-throughput

0.438

High

389244

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

389270

NU170
Nucleoporin NUP170

1

2

High-throughput

0.437

High

389334

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

389338

RRP6
Exosome complex exonuclease RRP6

1

5

High-throughput

0.437

High

389237

BUD3
Bud site selection protein 3

1

0

High-throughput

0.269

Low

389290

YEC3
Uncharacterized protein YEL023C

1

0

High-throughput

0.269

Low

389335

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.269

Low

389189

CALM
Calmodulin

1

0

High-throughput

0.261

Low

389195

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

389205

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

389216

CDC23
Anaphase-promoting complex subunit CDC23

1

0

High-throughput

0.261

Low

389229

SPO13
Meiosis-specific protein SPO13

1

0

High-throughput

0.261

Low

389230

VAN1
Mannan polymerase I complex VAN1 subunit

1

0

High-throughput

0.261

Low

389235

YCP2
Uncharacterized protein YCR001W

1

0

High-throughput

0.261

Low

389240

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

389242

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.261

Low

389279

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.261

Low

389295

YJ31
Uncharacterized protein YJR061W

1

0

High-throughput

0.261

Low

389330

ESF1
Pre-rRNA-processing protein ESF1

1

0

High-throughput

0.261

Low

389331

YL352
F-box protein YLR352W

1

0

High-throughput

0.261

Low

389347

HSH49
Protein HSH49

1

0

High-throughput

0.261

Low

389308

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.251

Low

389217

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.249

Low

389263

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

389265

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

389266

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

389276

YGP1
Protein YGP1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024