Protein: SYIC
Isoleucine--tRNA ligase, cytoplasmic (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)

Gene: SYIC, ILS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: P09436

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004822 - isoleucine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

450264

SSB1
Ribosome-associated molecular chaperone SSB1

4

7

Small-scale

0.666

High

450315

SSB2
Ribosome-associated molecular chaperone SSB2

3

7

Small-scale

0.624

High

430736

SYV
Valine--tRNA ligase, mitochondrial

1

5

Small-scale

0.618

High

450346

GET3
ATPase GET3

2

0

High-throughput

0.595

High

450303

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

1

High-throughput

0.588

High

450321

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

365612

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.571

High

450308

SSZ1
Ribosome-associated complex subunit SSZ1

2

4

Small-scale

0.571

High

446083

MYO1
Myosin-1

1

2

Small-scale

0.552

High

450263

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

450305

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

9

High-throughput

0.536

High

450348

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.536

High

450299

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

450270

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.493

High

450291

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.493

High

420204

CALM
Calmodulin

1

1

High-throughput

0.489

High

429584

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

4

High-throughput

0.489

High

450276

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.489

High

450295

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

High-throughput

0.489

High

450340

PML1
Pre-mRNA leakage protein 1

1

1

High-throughput

0.489

High

340586

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

342622

ENO1
Enolase 1

1

2

High-throughput

0.479

High

342825

ENO2
Enolase 2

1

2

High-throughput

0.479

High

388928

SYTC
Threonine--tRNA ligase, cytoplasmic

1

9

Small-scale

0.479

High

389197

HXKA
Hexokinase-1

1

1

High-throughput

0.479

High

406669

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

407633

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

413217

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

425671

RS19A
Small ribosomal subunit protein eS19A

1

1

Small-scale

0.479

High

450259

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.479

High

450261

IPB2
Protease B inhibitor 2

1

1

High-throughput

0.479

High

450271

KCY
Uridylate kinase

1

2

High-throughput

0.479

High

450277

PYRC
Dihydroorotase

1

2

High-throughput

0.479

High

450278

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

450280

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

450281

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

450286

MLS1
Malate synthase 1

1

2

High-throughput

0.479

High

450287

HS104
Heat shock protein 104

1

6

High-throughput

0.479

High

450290

HOG1
Mitogen-activated protein kinase HOG1

1

5

High-throughput

0.479

High

450292

ZUO1
Zuotin

1

6

Small-scale

0.479

High

450294

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

450296

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.479

High

450301

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

1

High-throughput

0.479

High

450304

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

450310

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

450317

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.479

High

450322

ARC1
tRNA-aminoacylation cofactor ARC1

1

7

Small-scale

0.479

High

450333

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

450336

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

450342

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

450344

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

450319

COPB
Coatomer subunit beta

1

2

High-throughput

0.470

High

450329

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.460

High

334409

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

0

High-throughput

0.458

High

343333

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

343498

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

405340

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

410864

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

450265

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

450267

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

450274

EF3A
Elongation factor 3A

1

0

Small-scale

0.458

High

450279

TKT1
Transketolase 1

1

0

High-throughput

0.458

High

450298

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

0

High-throughput

0.458

High

450312

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

450313

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

450324

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

450349

KCS1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.458

High

367632

EF1A
Elongation factor 1-alpha

1

5

High-throughput

0.445

High

450260

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

450262

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.445

High

450269

HSC82
ATP-dependent molecular chaperone HSC82

1

9

High-throughput

0.445

High

450282

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

450293

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

450297

HSP78
Heat shock protein 78, mitochondrial

1

5

High-throughput

0.445

High

450316

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.445

High

450318

DJP1
DnaJ-like protein 1

1

5

High-throughput

0.445

High

450338

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

5

High-throughput

0.445

High

450347

SMT3
Ubiquitin-like protein SMT3

1

4

High-throughput

0.439

High

450350

CMR1
DNA damage-binding protein CMR1

1

8

High-throughput

0.439

High

439945

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.437

High

450266

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

450273

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.437

High

450284

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

450300

PDX3
Pyridoxamine 5'-phosphate oxidase

1

1

High-throughput

0.437

High

450307

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.437

High

450330

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.437

High

450334

ESP1
Separin

1

1

High-throughput

0.437

High

450335

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.437

High

450337

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

450339

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

450343

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

450345

RRP6
Exosome complex exonuclease RRP6

1

4

High-throughput

0.437

High

450272

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

450275

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

450323

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

450326

DPH4
Diphthamide biosynthesis protein 4

1

4

High-throughput

0.407

High

450332

PTA1
Pre-tRNA-processing protein PTA1

2

0

High-throughput

0.319

High

450341

DIA2
Protein DIA2

1

0

High-throughput

0.279

Low

450288

TFC1
Transcription factor tau 95 kDa subunit

1

0

High-throughput

0.269

Low

336181

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

342449

TRPE
Anthranilate synthase component 1

1

0

Small-scale

0.249

Low

450268

AROF
Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited

1

0

High-throughput

0.249

Low

450283

NAM9
Small ribosomal subunit protein uS4m

1

0

High-throughput

0.249

Low

450285

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

450289

APE2
Aminopeptidase 2, mitochondrial

1

0

High-throughput

0.249

Low

450302

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

450306

ECM29
Proteasome component ECM29

1

0

High-throughput

0.249

Low

450309

SDO1L
Restriction of telomere capping protein 3

1

0

High-throughput

0.249

Low

450311

MPT5
Suppressor protein MPT5

1

0

High-throughput

0.249

Low

450314

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.249

Low

450320

EMP47
Protein EMP47

1

0

Small-scale

0.249

Low

450325

HOC1
Putative glycosyltransferase HOC1

1

0

Small-scale

0.249

Low

450327

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.249

Low

450328

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low

450331

PROA
Gamma-glutamyl phosphate reductase

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024