Protein: LHS1
Heat shock protein 70 homolog LHS1 (EC 3.6.1.-)

Gene: LHS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 124
UniProt ID: P36016

Gene Ontology (top 5):
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0005524 - ATP binding
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006986 - response to unfolded protein

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

560636

BIP
Endoplasmic reticulum chaperone BiP

6

14

Small-scale

0.942

High

490861

HSP71
Heat shock protein SSA1

3

17

High-throughput

0.839

High

510879

SSB1
Ribosome-associated molecular chaperone SSB1

1

16

High-throughput

0.691

High

493659

HSP72
Heat shock protein SSA2

1

16

High-throughput

0.618

High

694455

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.618

High

731117

BUD27
Bud site selection protein 27

2

2

High-throughput

0.576

High

703780

PRS6B
26S proteasome regulatory subunit 6B homolog

1

8

High-throughput

0.536

High

731133

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

19

High-throughput

0.536

High

731130

IPI3
Pre-rRNA-processing protein IPI3

2

20

High-throughput

0.526

High

614927

KC12
Casein kinase I homolog 2

1

5

High-throughput

0.501

High

629271

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

14

High-throughput

0.501

High

419468

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

2

High-throughput

0.494

High

640309

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

1

High-throughput

0.489

High

731164

DUF1
DUB-associated factor 1

1

18

High-throughput

0.489

High

605623

KIN3
Serine/threonine-protein kinase KIN3

1

20

High-throughput

0.481

High

731103

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

8

High-throughput

0.481

High

731142

FAR8
Factor arrest protein 8

1

2

High-throughput

0.481

High

543534

HSC82
ATP-dependent molecular chaperone HSC82

1

15

High-throughput

0.479

High

572761

PDI
Protein disulfide-isomerase

1

11

High-throughput

0.479

High

659959

MSP1
Outer mitochondrial transmembrane helix translocase

1

15

Small-scale

0.479

High

690727

EUG1
Protein disulfide-isomerase EUG1

1

11

High-throughput

0.479

High

690816

HS150
Cell wall mannoprotein HSP150

1

4

Small-scale

0.479

High

731101

FES1
Hsp70 nucleotide exchange factor FES1

1

11

High-throughput

0.479

High

523368

SRS2
ATP-dependent DNA helicase SRS2

1

8

High-throughput

0.445

High

585298

MYO2
Myosin-2

1

6

High-throughput

0.445

High

593620

DBP4
ATP-dependent RNA helicase HCA4

1

17

High-throughput

0.445

High

599966

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

4

High-throughput

0.445

High

636590

CDC48
Cell division control protein 48

1

11

High-throughput

0.445

High

667567

MCM2
DNA replication licensing factor MCM2

1

16

High-throughput

0.445

High

687687

BTAF1
TATA-binding protein-associated factor MOT1

1

20

High-throughput

0.445

High

697377

CHD1
Chromo domain-containing protein 1

1

11

High-throughput

0.445

High

699151

RAD5
DNA repair protein RAD5

1

20

High-throughput

0.445

High

731111

6P21
6-phosphofructo-2-kinase 1

1

12

High-throughput

0.445

High

731120

MTR4
ATP-dependent RNA helicase DOB1

1

16

High-throughput

0.445

High

731124

ORC5
Origin recognition complex subunit 5

1

2

High-throughput

0.445

High

731125

ACS2
Acetyl-coenzyme A synthetase 2

1

5

High-throughput

0.445

High

731128

GET1
Golgi to ER traffic protein 1

1

1

High-throughput

0.445

High

731138

PKR1
V-type ATPase assembly factor PKR1

1

3

High-throughput

0.445

High

731139

DHR1
Probable ATP-dependent RNA helicase DHR1

1

10

High-throughput

0.445

High

731143

ERP1
Protein ERP1

1

9

High-throughput

0.445

High

731145

SGPL
Sphingosine-1-phosphate lyase

1

15

High-throughput

0.445

High

731161

OSH2
Oxysterol-binding protein homolog 2

1

14

High-throughput

0.445

High

514550

BIK1
Nuclear fusion protein BIK1

1

9

High-throughput

0.439

High

678173

ZIP1
Synaptonemal complex protein ZIP1

1

3

High-throughput

0.439

High

705975

NIP80
Protein NIP100

1

15

High-throughput

0.439

High

710747

CASP
Protein CASP

1

12

High-throughput

0.439

High

731102

ETP1
RING finger protein ETP1

1

12

High-throughput

0.439

High

731106

MBO1
Gamma tubulin complex adapter SPC72

1

1

High-throughput

0.439

High

731114

GZF3
Protein GZF3

1

7

High-throughput

0.439

High

731119

MDV1
Mitochondrial division protein 1

1

20

High-throughput

0.439

High

731148

NDE1
Nuclear distribution protein nudE homolog 1

1

1

High-throughput

0.439

High

731149

HDA2
HDA1 complex subunit 2

1

2

High-throughput

0.439

High

731150

IMH1
Golgin IMH1

1

17

High-throughput

0.439

High

731156

SLK19
Kinetochore protein SLK19

1

11

High-throughput

0.439

High

731159

NOP53
Ribosome biogenesis protein NOP53

1

3

High-throughput

0.439

High

661890

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.437

High

730773

CENPA
Histone H3-like centromeric protein CSE4

1

12

High-throughput

0.437

High

731098

MCR1
NADH-cytochrome b5 reductase 2

1

11

Small-scale

0.437

High

731123

SF3B1
U2 snRNP component HSH155

1

11

High-throughput

0.437

High

731136

ULP1
Ubiquitin-like-specific protease 1

1

6

Small-scale

0.437

High

731140

SEG1
Eisosome protein SEG1

1

2

High-throughput

0.437

High

731151

STP4
Zinc finger protein STP4

1

6

High-throughput

0.437

High

731160

RRP6
Exosome complex exonuclease RRP6

1

3

High-throughput

0.437

High

334663

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

11

High-throughput

0.407

High

375353

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

8

High-throughput

0.407

High

392100

H2A1
Histone H2A.1

1

10

High-throughput

0.407

High

404327

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

3

High-throughput

0.407

High

416301

SIR3
Regulatory protein SIR3

1

9

High-throughput

0.407

High

557997

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

5

High-throughput

0.407

High

593309

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.407

High

595018

NUP1
Nucleoporin NUP1

1

20

High-throughput

0.407

High

601071

RT28
Small ribosomal subunit protein uS15m

1

2

High-throughput

0.407

High

605421

VATE
V-type proton ATPase subunit E

1

1

High-throughput

0.407

High

618227

AATC
Aspartate aminotransferase, cytoplasmic

1

4

High-throughput

0.407

High

619446

PSA2
Proteasome subunit alpha type-2

1

9

High-throughput

0.407

High

668077

TRXB1
Thioredoxin reductase 1

1

5

High-throughput

0.407

High

689865

ASF1
Histone chaperone ASF1

1

2

High-throughput

0.407

High

690910

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

9

High-throughput

0.407

High

691526

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.407

High

692745

SPT16
FACT complex subunit SPT16

1

10

High-throughput

0.407

High

693529

MED17
Mediator of RNA polymerase II transcription subunit 17

1

3

High-throughput

0.407

High

697073

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.407

High

701322

SPT4
Transcription elongation factor SPT4

1

2

High-throughput

0.407

High

707181

TRM2
tRNA

1

1

High-throughput

0.407

High

710157

NCBP1
Nuclear cap-binding protein complex subunit 1

1

4

High-throughput

0.407

High

715670

TAF14
Transcription initiation factor TFIID subunit 14

1

3

High-throughput

0.407

High

731099

PAM1
Protein PAM1

1

6

High-throughput

0.407

High

731100

SLT11
Pre-mRNA-splicing factor SLT11

1

2

High-throughput

0.407

High

731104

RPB11
DNA-directed RNA polymerase II subunit RPB11

1

2

High-throughput

0.407

High

731105

NUP60
Nucleoporin NUP60

1

2

High-throughput

0.407

High

731107

DPO5
rDNA transcriptional regulator POL5

1

3

High-throughput

0.407

High

731109

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

1

2

High-throughput

0.407

High

731110

RUXG
Small nuclear ribonucleoprotein G

1

7

High-throughput

0.407

High

731112

BZRD
Benzil reductase

1

7

High-throughput

0.407

High

731113

REF2
RNA end formation protein 2

1

1

High-throughput

0.407

High

731115

UTP10
U3 small nucleolar RNA-associated protein 10

1

3

High-throughput

0.407

High

731116

EPL1
Enhancer of polycomb-like protein 1

1

2

High-throughput

0.407

High

731118

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

High-throughput

0.407

High

731121

CSN12
Cop9 signalosome complex subunit 12

1

3

High-throughput

0.407

High

731122

MET7
Cystathionine gamma-synthase

1

10

High-throughput

0.407

High

731126

MLC1
Myosin light chain 1

1

5

High-throughput

0.407

High

731127

SP105
Spindle pole body component SPC105

1

1

High-throughput

0.407

High

731129

COPA
Coatomer subunit alpha

1

15

High-throughput

0.407

High

731131

NM111
Pro-apoptotic serine protease NMA111

1

5

High-throughput

0.407

High

731132

H3
Histone H3

1

12

High-throughput

0.407

High

731134

PTA1
Pre-tRNA-processing protein PTA1

1

3

High-throughput

0.407

High

731135

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

11

High-throughput

0.407

High

731137

UTP17
NET1-associated nuclear protein 1

1

11

High-throughput

0.407

High

731141

RRP5
rRNA biogenesis protein RRP5

1

8

High-throughput

0.407

High

731144

RT103
Regulator of Ty1 transposition protein 103

1

4

High-throughput

0.407

High

731146

YL281
Uncharacterized peptide chain release factor-like protein YLR281C, mitochondrial

1

3

High-throughput

0.407

High

731147

RU1C
U1 small nuclear ribonucleoprotein C

1

2

High-throughput

0.407

High

731152

IWR1
RNA polymerase II nuclear localization protein IWR1

1

2

High-throughput

0.407

High

731153

SDO1
Ribosome maturation protein SDO1

1

2

High-throughput

0.407

High

731154

DPP3
Probable dipeptidyl peptidase 3

1

2

High-throughput

0.407

High

731155

UTP16
U3 small nucleolar RNA-associated protein 16

1

2

High-throughput

0.407

High

731157

ESA1
Histone acetyltransferase ESA1

1

7

High-throughput

0.407

High

731158

CUB1

1

2

High-throughput

0.407

High

731162

YO098
Uncharacterized protein YOL098C

1

6

High-throughput

0.407

High

731163

RQC2
Ribosome quality control complex subunit 2

1

2

High-throughput

0.407

High

702650

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

406505

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.232

Low

604674

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.232

Low

731108

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024