Protein: MTR4
ATP-dependent RNA helicase DOB1 (EC 3.6.4.13) (mRNA transport regulator MTR4)

Gene: MTR4
Organism: Saccharomyces cerevisiae S288C
Interactions: 216
UniProt ID: P47047

Gene Ontology (top 5):
GO:0000292 - RNA fragment catabolic process
GO:0000460 - maturation of 5.8S rRNA
GO:0000467 - exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003677 - DNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

810951

RRP6
Exosome complex exonuclease RRP6

8

5

Small-scale

0.960

High

810910

DHR1
Probable ATP-dependent RNA helicase DHR1

4

19

Small-scale

0.873

High

810907

HAS1
ATP-dependent RNA helicase HAS1

2

17

Small-scale

0.776

High

772643

UTP18
U3 small nucleolar RNA-associated protein 18

2

0

Small-scale

0.773

High

810885

PAP2
Poly(A) RNA polymerase protein 2

14

5

Small-scale

0.762

High

810870

TRF5
Poly(A) RNA polymerase protein 1

8

5

Small-scale

0.754

High

733575

RL1D1
Ribosome biogenesis protein UTP30

2

4

Small-scale

0.754

High

744206

MAK5
ATP-dependent RNA helicase MAK5

2

17

Small-scale

0.754

High

767379

UTP7
U3 small nucleolar RNA-associated protein 7

2

20

Small-scale

0.754

High

810911

UTP15
U3 small nucleolar RNA-associated protein 15

2

17

Small-scale

0.754

High

810919

UTP13
U3 small nucleolar RNA-associated protein 13

2

20

Small-scale

0.754

High

810920

UTP21
U3 small nucleolar RNA-associated protein 21

2

15

Small-scale

0.754

High

810927

UTP4
U3 small nucleolar RNA-associated protein 4

2

20

Small-scale

0.754

High

810957

DBP10
ATP-dependent RNA helicase DBP10

2

16

Small-scale

0.754

High

810960

AIR2
Protein AIR2

8

9

Small-scale

0.751

High

810948

NOP53
Ribosome biogenesis protein NOP53

6

3

Small-scale

0.736

High

774805

AIR1
Protein AIR1

4

8

Small-scale

0.687

High

416017

DED1
ATP-dependent RNA helicase DED1

1

11

High-throughput

0.665

High

810864

MTR4
ATP-dependent RNA helicase DOB1

1

15

High-throughput

0.665

High

810876

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

17

High-throughput

0.665

High

733858

RPF2
Ribosome biogenesis protein RPF2

3

1

Small-scale

0.650

High

748646

ENP1
Essential nuclear protein 1

3

3

High-throughput

0.640

High

792485

UTP10
U3 small nucleolar RNA-associated protein 10

3

1

Small-scale

0.640

High

810903

NOG1
Nucleolar GTP-binding protein 1

3

4

Small-scale

0.640

High

810913

UTP14
U3 small nucleolar RNA-associated protein 14

3

2

Small-scale

0.640

High

758911

NAB3
Nuclear polyadenylated RNA-binding protein 3

2

1

High-throughput

0.621

High

558134

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.618

High

593542

DBP3
ATP-dependent RNA helicase DBP3

1

12

Small-scale

0.618

High

624123

DBP2
ATP-dependent RNA helicase DBP2

1

9

Small-scale

0.618

High

635600

PWP2
Periodic tryptophan protein 2

1

17

High-throughput

0.618

High

638801

SPB4
ATP-dependent rRNA helicase SPB4

1

17

Small-scale

0.618

High

699697

DRS1
ATP-dependent RNA helicase DRS1

1

17

Small-scale

0.618

High

707107

DCA13
Protein SOF1

1

19

High-throughput

0.618

High

733136

DBP7
ATP-dependent RNA helicase DBP7

1

17

Small-scale

0.618

High

742872

GBLP
Small ribosomal subunit protein RACK1

1

20

High-throughput

0.618

High

754139

CIC1
Proteasome-interacting protein CIC1

1

4

Small-scale

0.618

High

778621

PRP17
Pre-mRNA-processing factor 17

1

20

Small-scale

0.618

High

799826

ROK1
ATP-dependent RNA helicase ROK1

1

13

High-throughput

0.618

High

810887

DBP6
ATP-dependent RNA helicase DBP6

1

14

Small-scale

0.618

High

810891

SQS1
Protein SQS1

1

1

Small-scale

0.618

High

810904

UTP17
NET1-associated nuclear protein 1

1

13

High-throughput

0.618

High

810914

ERB1
Ribosome biogenesis protein ERB1

1

12

Small-scale

0.618

High

810921

DBP9
ATP-dependent RNA helicase DBP9

1

16

Small-scale

0.618

High

810924

RRP9
Ribosomal RNA-processing protein 9

1

20

High-throughput

0.618

High

810946

YTM1
Ribosome biogenesis protein YTM1

1

20

Small-scale

0.618

High

810955

UTP12
U3 small nucleolar RNA-associated protein 12

1

17

High-throughput

0.618

High

810959

RUVB2
RuvB-like protein 2

1

6

High-throughput

0.618

High

630219

RRP43
Exosome complex component RRP43

2

3

High-throughput

0.601

High

810954

MAK21
Ribosome biogenesis protein MAK21

2

2

Small-scale

0.601

High

579435

GBB
Guanine nucleotide-binding protein subunit beta

1

18

High-throughput

0.595

High

634672

KRR1
KRR1 small subunit processome component

2

3

High-throughput

0.584

High

711049

UTP11
U3 small nucleolar RNA-associated protein 11

2

1

Small-scale

0.584

High

754969

RRP4
Exosome complex component RRP4

2

9

Small-scale

0.584

High

810878

LSG1
Large subunit GTPase 1

2

7

Small-scale

0.584

High

810880

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

Small-scale

0.584

High

810881

RRP46
Exosome complex component RRP46

2

14

Small-scale

0.584

High

810882

PESC
Pescadillo homolog

2

2

Small-scale

0.584

High

810888

NOG2
Nucleolar GTP-binding protein 2

2

7

Small-scale

0.584

High

810890

CSL4
Exosome complex component CSL4

2

3

High-throughput

0.584

High

810892

NOP13
Nucleolar protein 13

2

16

Small-scale

0.584

High

810900

UTP6
U3 small nucleolar RNA-associated protein 6

2

4

Small-scale

0.584

High

810909

UTP5
U3 small nucleolar RNA-associated protein 5

2

16

Small-scale

0.584

High

810917

RRP45
Exosome complex component RRP45

2

13

Small-scale

0.584

High

810925

NOC4
Nucleolar complex protein 4

2

2

High-throughput

0.584

High

366528

HSP82
ATP-dependent molecular chaperone HSP82

2

12

High-throughput

0.571

High

544002

HSC82
ATP-dependent molecular chaperone HSC82

2

12

High-throughput

0.571

High

628223

SIS1
Protein SIS1

2

8

High-throughput

0.571

High

715943

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

Small-scale

0.559

High

756751

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

Small-scale

0.559

High

810883

UTP8
U3 small nucleolar RNA-associated protein 8

2

0

Small-scale

0.559

High

810886

MPP6
M-phase phosphoprotein 6 homolog

2

0

Small-scale

0.559

High

743585

HMT1
Protein arginine N-methyltransferase 1

1

8

High-throughput

0.554

High

481178

RL1A
Large ribosomal subunit protein uL1A

1

6

High-throughput

0.553

High

494325

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.552

High

768805

SSB2
Ribosome-associated molecular chaperone SSB2

2

15

High-throughput

0.552

High

707886

GCN1
eIF-2-alpha kinase activator GCN1

2

11

High-throughput

0.537

High

511840

SSB1
Ribosome-associated molecular chaperone SSB1

1

15

High-throughput

0.536

High

696006

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.536

High

810872

RL4B
Large ribosomal subunit protein uL4B

1

5

High-throughput

0.536

High

810884

NRD1
Protein NRD1

1

2

High-throughput

0.536

High

700497

RSSA1
Small ribosomal subunit protein uS2A

2

5

High-throughput

0.521

High

376837

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

13

High-throughput

0.515

High

810873

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.515

High

810874

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

17

High-throughput

0.515

High

810940

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.515

High

810953

YRA1
RNA annealing protein YRA1

1

14

High-throughput

0.515

High

675118

PSO2
DNA cross-link repair protein PSO2/SNM1

1

0

High-throughput

0.493

High

693932

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

High-throughput

0.493

High

810902

RPM2
Ribonuclease P protein component, mitochondrial

1

0

Small-scale

0.480

High

407154

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

409847

NOT2
General negative regulator of transcription subunit 2

1

3

Small-scale

0.479

High

410413

SC160
Protein SCP160

1

14

High-throughput

0.479

High

413590

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

480186

RS6A
Small ribosomal subunit protein eS6A

1

6

High-throughput

0.479

High

501228

MAK16
Protein MAK16

1

1

Small-scale

0.479

High

633964

GBP2
Serine/arginine

1

11

Small-scale

0.479

High

645066

RL16A
Large ribosomal subunit protein uL13A

1

4

High-throughput

0.479

High

645529

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

649906

CDC15
Cell division control protein 15

1

10

High-throughput

0.479

High

650328

SPT5
Transcription elongation factor SPT5

1

5

High-throughput

0.479

High

662634

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

688314

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

693133

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

4

High-throughput

0.479

High

700075

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

5

High-throughput

0.479

High

703074

MRT4
Ribosome assembly factor MRT4

1

4

Small-scale

0.479

High

713704

NOT4
General negative regulator of transcription subunit 4

1

1

Small-scale

0.479

High

731828

EBP2
rRNA-processing protein EBP2

1

2

Small-scale

0.479

High

752537

RS20
Small ribosomal subunit protein uS10

1

5

High-throughput

0.479

High

755178

LRP1
Exosome complex protein LRP1

1

1

High-throughput

0.479

High

755300

RPF1
Ribosome production factor 1

1

1

Small-scale

0.479

High

757853

HRB1
Serine/arginine

1

12

Small-scale

0.479

High

764197

NOC2
Nucleolar complex protein 2

1

1

Small-scale

0.479

High

766654

NUG1
Nuclear GTP-binding protein NUG1

1

7

Small-scale

0.479

High

776449

RLP7
Ribosome biogenesis protein RLP7

1

5

Small-scale

0.479

High

809560

RRP41
Exosome complex component SKI6

1

17

High-throughput

0.479

High

810866

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

2

High-throughput

0.479

High

810868

MTR3
Exosome complex component MTR3

1

1

High-throughput

0.479

High

810877

NSA1
Ribosome biogenesis protein NSA1

1

1

Small-scale

0.479

High

810889

CAF40
Protein CAF40

1

1

Small-scale

0.479

High

810894

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

810895

NOP15
Ribosome biogenesis protein 15

1

17

High-throughput

0.479

High

810896

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

4

High-throughput

0.479

High

810898

NOP3
Serine/arginine

1

20

Small-scale

0.479

High

810901

MLP1
Protein MLP1

1

14

High-throughput

0.479

High

810905

ESP1
Separin

1

1

High-throughput

0.479

High

810906

TOM1
E3 ubiquitin-protein ligase TOM1

1

12

High-throughput

0.479

High

810908

ARX1
Probable metalloprotease ARX1

1

3

Small-scale

0.479

High

810915

RRP5
rRNA biogenesis protein RRP5

1

18

High-throughput

0.479

High

810916

FCF1
rRNA-processing protein FCF1

1

2

High-throughput

0.479

High

810930

RLP24
Ribosome biogenesis protein RLP24

1

2

Small-scale

0.479

High

810931

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

2

High-throughput

0.479

High

810932

RRP44
Exosome complex exonuclease DIS3

1

8

High-throughput

0.479

High

810933

NOP12
Nucleolar protein 12

1

20

Small-scale

0.479

High

810934

BRX1
Ribosome biogenesis protein BRX1

1

6

Small-scale

0.479

High

810936

RRP40
Exosome complex component RRP40

1

3

High-throughput

0.479

High

810941

NCBP2
Nuclear cap-binding protein subunit 2

1

20

High-throughput

0.479

High

810943

BMS1
Ribosome biogenesis protein BMS1

1

5

High-throughput

0.479

High

810944

TMA46
Translation machinery-associated protein 46

1

3

High-throughput

0.479

High

810945

MDN1
Midasin

1

2

Small-scale

0.479

High

810950

SAS10
Something about silencing protein 10

1

1

High-throughput

0.479

High

810952

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

810956

RRP42
Exosome complex component RRP42

1

13

High-throughput

0.479

High

810958

NOP56
Nucleolar protein 56

1

7

High-throughput

0.479

High

810961

NOP58
Nucleolar protein 58

1

7

High-throughput

0.479

High

810963

NOP14
Nucleolar complex protein 14

1

1

High-throughput

0.479

High

478677

IPB2
Protease B inhibitor 2

1

0

High-throughput

0.458

High

589031

PYRC
Dihydroorotase

1

0

High-throughput

0.458

High

630507

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

732226

RRP14
Ribosomal RNA-processing protein 14

1

0

Small-scale

0.458

High

746154

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

756840

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.458

High

768016

NSA2
Ribosome biogenesis protein NSA2

1

0

Small-scale

0.458

High

768086

LCP5
U3 small nucleolar ribonucleoprotein protein LCP5

1

0

High-throughput

0.458

High

774256

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

774721

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.458

High

775369

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

784506

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.458

High

810867

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

810922

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

810923

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

810926

BFR2
Protein BFR2

1

0

High-throughput

0.458

High

810929

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

810938

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.458

High

810942

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

Small-scale

0.458

High

810947

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

810949

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

810962

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

810964

PNO1
Pre-rRNA-processing protein PNO1

1

0

High-throughput

0.458

High

810935

RBX1
RING-box protein HRT1

1

3

High-throughput

0.457

High

424588

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

491679

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

633348

MAS5
Mitochondrial protein import protein MAS5

1

10

High-throughput

0.445

High

694998

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

705365

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

731120

LHS1
Heat shock protein 70 homolog LHS1

1

16

High-throughput

0.445

High

757301

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.445

High

760643

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.445

High

760762

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.445

High

766081

HSP7E
Heat shock protein SSC3, mitochondrial

1

9

High-throughput

0.445

High

810865

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.445

High

810875

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.445

High

810897

H3
Histone H3

1

14

High-throughput

0.445

High

810918

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

20

High-throughput

0.445

High

383227

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.437

High

426029

RS19A
Small ribosomal subunit protein eS19A

1

7

High-throughput

0.437

High

471137

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472272

RL31A
Large ribosomal subunit protein eL31A

1

7

High-throughput

0.437

High

480755

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.437

High

481663

RL18B
Large ribosomal subunit protein eL18B

1

2

High-throughput

0.437

High

524369

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

535037

RL3
Large ribosomal subunit protein uL3

1

2

Small-scale

0.437

High

715292

CYPD
Peptidyl-prolyl cis-trans isomerase D

1

1

High-throughput

0.437

High

729992

RS27A
Small ribosomal subunit protein eS27A

1

4

High-throughput

0.437

High

758674

TEM1
Protein TEM1

1

1

High-throughput

0.437

High

762344

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

774110

TM108
Protein TMA108

1

3

High-throughput

0.437

High

810871

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.437

High

810899

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

810928

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

810937

SKI7
Superkiller protein 7

1

3

High-throughput

0.437

High

810939

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

399531

RLA0
Large ribosomal subunit protein uL10

1

4

High-throughput

0.407

High

541747

SEC63
Protein translocation protein SEC63

1

8

High-throughput

0.407

High

628996

SCJ1
DnaJ-related protein SCJ1

1

6

High-throughput

0.407

High

667217

RL8B
Large ribosomal subunit protein eL8B

1

9

High-throughput

0.407

High

810042

PFD1
Prefoldin subunit 1

1

1

High-throughput

0.407

High

810869

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.407

High

810879

JAC1
J-type co-chaperone JAC1, mitochondrial

1

4

High-throughput

0.407

High

810893

PFD4
Prefoldin subunit 4

1

2

High-throughput

0.407

High

810912

PFD5
Prefoldin subunit 5

1

2

High-throughput

0.407

High

581302

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.269

Low

596653

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.269

Low

336254

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

677527

MLS1
Malate synthase 1

1

0

High-throughput

0.249

Low

744326

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024