Protein: RL4
Large ribosomal subunit protein uL4 (50S ribosomal protein L4)

Gene: RL4, rplD
Organism: Escherichia coli K-12
Interactions: 243
UniProt ID: P60723

Gene Ontology (top 5):
GO:0001070 - RNA-binding transcription regulator activity
GO:0002181 - cytoplasmic translation
GO:0003677 - DNA binding
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464354

CSPE
Cold shock-like protein CspE

3

8

High-throughput

0.657

High

465487

CSPC
Cold shock-like protein CspC

3

8

High-throughput

0.657

High

889952

RL2
Large ribosomal subunit protein uL2

3

3

High-throughput

0.657

High

340886

RPOD
RNA polymerase sigma factor RpoD

3

0

High-throughput

0.629

High

599885

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

3

0

High-throughput

0.629

High

892242

RL22
Large ribosomal subunit protein uL22

1

2

High-throughput

0.625

High

459561

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

3

0

High-throughput

0.616

High

462382

RS5
Small ribosomal subunit protein uS5

2

1

High-throughput

0.612

High

737119

CBPA
Curved DNA-binding protein

2

1

High-throughput

0.612

High

741817

RLUB
Ribosomal large subunit pseudouridine synthase B

2

3

High-throughput

0.612

High

892262

DCYD
D-cysteine desulfhydrase

2

2

High-throughput

0.601

High

393756

PNP
Polyribonucleotide nucleotidyltransferase

2

1

High-throughput

0.588

High

460836

RL1
Large ribosomal subunit protein uL1

2

2

High-throughput

0.588

High

461326

RS10
Small ribosomal subunit protein uS10

2

1

High-throughput

0.588

High

461482

RS13
Small ribosomal subunit protein uS13

2

1

High-throughput

0.588

High

462024

RS3
Small ribosomal subunit protein uS3

2

2

High-throughput

0.588

High

465577

RL13
Large ribosomal subunit protein uL13

2

2

High-throughput

0.588

High

466070

IOJAP
Ribosomal silencing factor RsfS

2

1

High-throughput

0.588

High

467926

RL14
Large ribosomal subunit protein uL14

2

2

High-throughput

0.588

High

469346

RL6
Large ribosomal subunit protein uL6

2

1

High-throughput

0.588

High

534562

SELB
Selenocysteine-specific elongation factor

2

4

High-throughput

0.588

High

892244

RL5
Large ribosomal subunit protein uL5

2

1

High-throughput

0.588

High

469590

SSB
Single-stranded DNA-binding protein

2

1

High-throughput

0.584

High

460131

IPYR
Inorganic pyrophosphatase

2

0

High-throughput

0.576

High

468004

RL23
Large ribosomal subunit protein uL23

2

0

High-throughput

0.576

High

468783

NUSG
Transcription termination/antitermination protein NusG

2

0

High-throughput

0.576

High

761677

RSGA
Small ribosomal subunit biogenesis GTPase RsgA

2

0

High-throughput

0.576

High

892256

RLMI
Ribosomal RNA large subunit methyltransferase I

2

0

High-throughput

0.569

High

343898

SYGA
Glycine--tRNA ligase alpha subunit

2

0

High-throughput

0.563

High

368586

DNAA
Chromosomal replication initiator protein DnaA

2

0

High-throughput

0.563

High

430840

SYL
Leucine--tRNA ligase

2

0

High-throughput

0.563

High

458958

HFQ
RNA-binding protein Hfq

2

0

High-throughput

0.563

High

462230

RS4
Small ribosomal subunit protein uS4

2

0

High-throughput

0.563

High

462947

TGT
Queuine tRNA-ribosyltransferase

2

0

High-throughput

0.563

High

463985

RPOB
DNA-directed RNA polymerase subunit beta

2

0

High-throughput

0.563

High

466052

YBCJ
Putative RNA-binding protein YbcJ

2

0

High-throughput

0.563

High

469088

SSPB
Stringent starvation protein B

2

0

High-throughput

0.563

High

469702

YHBY
RNA-binding protein YhbY

2

0

High-throughput

0.563

High

542782

HELD
DNA helicase IV

2

0

High-throughput

0.563

High

589334

PARE
DNA topoisomerase 4 subunit B

2

0

High-throughput

0.563

High

661029

HOLC
DNA polymerase III subunit chi

2

0

High-throughput

0.563

High

892251

NFI
Endonuclease V

2

0

High-throughput

0.563

High

404428

T1SK
Type I restriction enzyme EcoKI specificity subunit

2

0

High-throughput

0.547

High

463040

TIG
Trigger factor

2

0

Small-scale

0.545

High

839884

END8
Endonuclease 8

2

1

High-throughput

0.537

High

393707

APPY
HTH-type transcriptional regulator AppY

1

1

High-throughput

0.536

High

449143

RHAS
HTH-type transcriptional activator RhaS

1

1

High-throughput

0.536

High

460384

RF1
Peptide chain release factor RF1

1

4

High-throughput

0.536

High

460501

RL11
Large ribosomal subunit protein uL11

1

2

High-throughput

0.536

High

464369

CSPG
Cold shock-like protein CspG

1

8

High-throughput

0.536

High

464377

CSPI
Cold shock-like protein CspI

1

8

High-throughput

0.536

High

466487

CYSK
Cysteine synthase A

1

1

High-throughput

0.536

High

467135

DBHA
DNA-binding protein HU-alpha

1

1

High-throughput

0.536

High

621143

FMT
Methionyl-tRNA formyltransferase

1

1

High-throughput

0.536

High

621937

RECG
ATP-dependent DNA helicase RecG

1

1

High-throughput

0.536

High

639425

RHLE
ATP-dependent RNA helicase RhlE

1

2

High-throughput

0.536

High

739464

CSPB
Cold shock-like protein CspB

1

8

High-throughput

0.536

High

776575

ARFB
Peptidyl-tRNA hydrolase ArfB

1

1

High-throughput

0.536

High

892250

GRCA
Autonomous glycyl radical cofactor

1

1

High-throughput

0.536

High

381662

3MG2
DNA-3-methyladenine glycosylase 2

1

0

High-throughput

0.513

High

389175

SYE
Glutamate--tRNA ligase

1

0

High-throughput

0.513

High

416873

AGAL
Alpha-galactosidase

1

0

High-throughput

0.513

High

421241

SDIA
Regulatory protein SdiA

1

0

High-throughput

0.513

High

427826

CHER
Chemotaxis protein methyltransferase

1

0

High-throughput

0.513

High

457431

END4
Endonuclease 4

1

0

High-throughput

0.513

High

458423

COAD
Phosphopantetheine adenylyltransferase

1

0

High-throughput

0.513

High

458481

DEF
Peptide deformylase

1

0

High-throughput

0.513

High

461098

RL29
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

461565

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.513

High

464669

MUG
G/U mismatch-specific DNA glycosylase

1

0

High-throughput

0.513

High

464871

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

1

0

High-throughput

0.513

High

466211

KBL
2-amino-3-ketobutyrate coenzyme A ligase

1

0

High-throughput

0.513

High

467258

HSLR
Heat shock protein 15

1

0

High-throughput

0.513

High

467552

YEBG
Uncharacterized protein YebG

1

0

High-throughput

0.513

High

467726

SUHB
Nus factor SuhB

1

0

High-throughput

0.513

High

467840

RLMM
Ribosomal RNA large subunit methyltransferase M

1

0

High-throughput

0.513

High

468308

MIAB
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase

1

0

High-throughput

0.513

High

469020

GLRR
Transcriptional regulatory protein GlrR

1

0

High-throughput

0.513

High

469625

THIO2
Thioredoxin 2

1

0

High-throughput

0.513

High

469914

ISCX
Protein IscX

1

0

High-throughput

0.513

High

621855

YFFB
Protein YffB

1

0

High-throughput

0.513

High

621917

INTD
Prophage integrase IntD

1

0

High-throughput

0.513

High

621926

ACPS
Holo-[acyl-carrier-protein] synthase

1

0

High-throughput

0.513

High

643638

FLIS
Flagellar secretion chaperone FliS

1

0

High-throughput

0.513

High

661022

TREC
Trehalose-6-phosphate hydrolase

1

0

High-throughput

0.513

High

682312

TRMN6
tRNA1(Val)

1

0

High-throughput

0.513

High

686126

YIIS
UPF0381 protein YiiS

1

0

High-throughput

0.513

High

702449

SFGH2
S-formylglutathione hydrolase YeiG

1

0

High-throughput

0.513

High

702454

RIHB
Pyrimidine-specific ribonucleoside hydrolase RihB

1

0

High-throughput

0.513

High

738640

RSMB
Ribosomal RNA small subunit methyltransferase B

1

0

High-throughput

0.513

High

741740

RLMJ
Ribosomal RNA large subunit methyltransferase J

1

0

High-throughput

0.513

High

741747

YHJB
Putative HTH-type transcriptional regulator YhjB

1

0

High-throughput

0.513

High

761746

RSMC
Ribosomal RNA small subunit methyltransferase C

1

0

High-throughput

0.513

High

788304

YHAK
Pirin-like protein YhaK

1

0

High-throughput

0.513

High

795474

LPXH
UDP-2,3-diacylglucosamine hydrolase

1

0

High-throughput

0.513

High

892270

CSE2
CRISPR system Cascade subunit CasB

1

0

High-throughput

0.513

High

892272

MURR
HTH-type transcriptional regulator MurR

1

0

High-throughput

0.513

High

892276

XDHB
Putative xanthine dehydrogenase FAD-binding subunit XdhB

1

0

High-throughput

0.513

High

892277

NORV
Anaerobic nitric oxide reductase flavorubredoxin

1

0

High-throughput

0.513

High

469136

RELA
GTP pyrophosphokinase

1

1

High-throughput

0.489

High

340929

DPO1
DNA polymerase I

1

1

High-throughput

0.484

High

449116

PFLB
Formate acetyltransferase 1

1

1

High-throughput

0.484

High

458322

CLPP
ATP-dependent Clp protease proteolytic subunit

1

1

High-throughput

0.484

High

458581

EFG
Elongation factor G

1

2

High-throughput

0.484

High

458612

DER
GTPase Der

1

5

High-throughput

0.484

High

459020

IHFB
Integration host factor subunit beta

1

1

High-throughput

0.484

High

459285

DNAK
Chaperone protein DnaK

1

3

High-throughput

0.484

High

461363

RS11
Small ribosomal subunit protein uS11

1

1

High-throughput

0.484

High

461866

RS2
Small ribosomal subunit protein uS2

1

1

High-throughput

0.484

High

465166

DEAD
ATP-dependent RNA helicase DeaD

1

2

High-throughput

0.484

High

465327

ULAR
HTH-type transcriptional regulator UlaR

1

1

High-throughput

0.484

High

465439

CSPA
Cold shock protein CspA

1

8

High-throughput

0.484

High

465696

RLUC
Ribosomal large subunit pseudouridine synthase C

1

3

High-throughput

0.484

High

469157

SPOT
Bifunctional

1

1

High-throughput

0.484

High

469252

RL17
Large ribosomal subunit protein bL17

1

2

High-throughput

0.484

High

542963

SRLR
Glucitol operon repressor

1

1

High-throughput

0.484

High

599085

SRMB
ATP-dependent RNA helicase SrmB

1

3

High-throughput

0.484

High

633788

MNME
tRNA modification GTPase MnmE

1

4

High-throughput

0.484

High

890026

RL3
Large ribosomal subunit protein uL3

1

3

High-throughput

0.484

High

891482

RL24
Large ribosomal subunit protein uL24

1

1

High-throughput

0.484

High

892241

LEPA
Elongation factor 4

1

6

High-throughput

0.484

High

465343

ETTA
Energy-dependent translational throttle protein EttA

1

0

High-throughput

0.479

High

525147

FDHE
Protein FdhE

1

0

High-throughput

0.479

High

467830

YGAM
Uncharacterized protein YgaM

1

1

High-throughput

0.479

High

469665

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

1

2

High-throughput

0.479

High

336976

PHSM
Maltodextrin phosphorylase

1

0

High-throughput

0.464

High

357118

RS7
Small ribosomal subunit protein uS7

1

0

High-throughput

0.464

High

392831

KDSB
3-deoxy-manno-octulosonate cytidylyltransferase

1

0

High-throughput

0.464

High

449057

GRPE
Protein GrpE

1

0

High-throughput

0.464

High

458404

HSLU
ATP-dependent protease ATPase subunit HslU

1

0

High-throughput

0.464

High

458732

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

458758

FIS
DNA-binding protein Fis

1

0

High-throughput

0.464

High

458880

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.464

High

459607

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.464

High

459871

MURA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

1

0

High-throughput

0.464

High

460001

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.464

High

460192

HSLV
ATP-dependent protease subunit HslV

1

0

High-throughput

0.464

High

460219

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.464

High

460303

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

460454

RL10
Large ribosomal subunit protein uL10

1

0

High-throughput

0.464

High

462696

RPOA
DNA-directed RNA polymerase subunit alpha

1

0

High-throughput

0.464

High

463417

UVRC
UvrABC system protein C

1

0

High-throughput

0.464

High

463460

YIHI
Der GTPase-activating protein YihI

1

0

High-throughput

0.464

High

463905

RPOC
DNA-directed RNA polymerase subunit beta'

1

0

High-throughput

0.464

High

464786

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

464917

PPIC
Peptidyl-prolyl cis-trans isomerase C

1

0

High-throughput

0.464

High

466449

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

0

High-throughput

0.464

High

466652

DPS
DNA protection during starvation protein

1

0

High-throughput

0.464

High

467008

DNAB
Replicative DNA helicase

1

0

High-throughput

0.464

High

468078

MAP1
Methionine aminopeptidase

1

0

High-throughput

0.464

High

468760

NUSA
Transcription termination/antitermination protein NusA

1

0

High-throughput

0.464

High

469190

RHO
Transcription termination factor Rho

1

0

High-throughput

0.464

High

469564

SRP54
Signal recognition particle protein

1

0

High-throughput

0.464

High

469922

RLME
Ribosomal RNA large subunit methyltransferase E

1

0

High-throughput

0.464

High

483591

RCSA
Transcriptional regulatory protein RcsA

1

0

High-throughput

0.464

High

488861

SECA
Protein translocase subunit SecA

1

0

High-throughput

0.464

High

489547

DPO3A
DNA polymerase III subunit alpha

1

0

High-throughput

0.464

High

561150

ICLR
Transcriptional repressor IclR

1

0

High-throughput

0.464

High

599054

RNR
Ribonuclease R

1

0

High-throughput

0.464

High

599104

RNE
Ribonuclease E

1

0

High-throughput

0.464

High

608834

MUKB
Chromosome partition protein MukB

1

0

High-throughput

0.464

High

739447

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.464

High

740106

DCTR
HTH-type transcriptional regulator DctR

1

0

High-throughput

0.464

High

892243

RISB
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.464

High

892245

ISPH
4-hydroxy-3-methylbut-2-enyl diphosphate reductase

1

0

High-throughput

0.464

High

892254

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.464

High

463638

YEEX
UPF0265 protein YeeX

1

0

High-throughput

0.458

High

464047

YJGA
UPF0307 protein YjgA

1

0

High-throughput

0.458

High

466363

PCNB
Poly(A) polymerase I

1

0

High-throughput

0.458

High

467656

KPYK1
Pyruvate kinase I

1

0

High-throughput

0.458

High

799588

YRAR

1

0

High-throughput

0.458

High

892246

GMHBB
D-glycero-beta-D-manno-heptose-1,7-bisphosphate 7-phosphatase

1

0

High-throughput

0.458

High

892252

YTFE
Iron-sulfur cluster repair protein YtfE

1

0

High-throughput

0.458

High

892253

CSRA
Carbon storage regulator

1

0

High-throughput

0.458

High

892259

YNCE
Uncharacterized protein YncE

1

0

High-throughput

0.458

High

892275

MENI
1,4-dihydroxy-2-naphthoyl-CoA hydrolase

1

0

High-throughput

0.458

High

474187

EFTU1
Elongation factor Tu 1

1

3

High-throughput

0.445

High

474240

EFTU2
Elongation factor Tu 2

1

3

High-throughput

0.445

High

637110

YIDC
Membrane protein insertase YidC

1

1

Small-scale

0.437

High

892249

YQJD
Uncharacterized protein YqjD

1

1

High-throughput

0.437

High

459734

KPRS
Ribose-phosphate pyrophosphokinase

1

0

High-throughput

0.426

High

465356

ZNUC
Zinc import ATP-binding protein ZnuC

2

0

High-throughput

0.319

High

742684

USPF
Universal stress protein F

2

0

High-throughput

0.318

High

602065

RECJ
Single-stranded-DNA-specific exonuclease RecJ

2

0

High-throughput

0.313

High

465882

FTSH
ATP-dependent zinc metalloprotease FtsH

2

0

High-throughput

0.307

High

536273

TOP3
DNA topoisomerase 3

2

0

High-throughput

0.307

High

892255

YBJX
Uncharacterized protein YbjX

2

0

High-throughput

0.307

High

342438

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.279

Low

367457

RBSB
Ribose import binding protein RbsB

1

0

High-throughput

0.279

Low

439038

YCIH
Uncharacterized protein YciH

1

0

High-throughput

0.279

Low

466125

TUSE
Sulfurtransferase TusE

1

0

High-throughput

0.279

Low

466780

FLIG
Flagellar motor switch protein FliG

1

0

High-throughput

0.279

Low

467583

YECA
Uncharacterized protein YecA

1

0

High-throughput

0.279

Low

467870

YGIC
Putative acid--amine ligase YgiC

1

0

High-throughput

0.279

Low

468242

DMA
DNA adenine methylase

1

0

High-throughput

0.279

Low

468738

NUOE
NADH-quinone oxidoreductase subunit E

1

0

High-throughput

0.279

Low

468962

ATL
DNA base-flipping protein

1

0

High-throughput

0.279

Low

469203

RIBF
Bifunctional riboflavin kinase/FMN adenylyltransferase

1

0

High-throughput

0.279

Low

513925

DAMX
Cell division protein DamX

1

0

High-throughput

0.279

Low

617800

GLXK1
Glycerate 2-kinase

1

0

High-throughput

0.279

Low

697520

YJBM
Uncharacterized protein YjbM

1

0

High-throughput

0.279

Low

697525

YJCF
Uncharacterized protein YjcF

1

0

High-throughput

0.279

Low

703323

YEBE
Inner membrane protein YebE

1

0

High-throughput

0.279

Low

704864

YEHZ
Glycine betaine-binding protein YehZ

1

0

High-throughput

0.279

Low

704873

YOHF
Uncharacterized oxidoreductase YohF

1

0

High-throughput

0.279

Low

736165

AMIA
N-acetylmuramoyl-L-alanine amidase AmiA

1

0

High-throughput

0.279

Low

739547

YCHJ
UPF0225 protein YchJ

1

0

High-throughput

0.279

Low

799592

YHBQ
UPF0213 protein YhbQ

1

0

High-throughput

0.279

Low

807977

AAAT
L-amino acid N-acetyltransferase AaaT

1

0

High-throughput

0.279

Low

852348

RATB
UPF0125 protein RatB

1

0

High-throughput

0.279

Low

892247

EUTS
Bacterial microcompartment shell protein EutS

1

0

High-throughput

0.279

Low

892257

YMGA
Probable two-component-system connector protein YmgA

1

0

High-throughput

0.279

Low

892260

YNEG
Uncharacterized protein YneG

1

0

High-throughput

0.279

Low

892261

YOBB
Uncharacterized protein YobB

1

0

High-throughput

0.279

Low

892264

YEGL
Uncharacterized protein YegL

1

0

High-throughput

0.279

Low

892265

YFDS
Uncharacterized protein YfdS

1

0

High-throughput

0.279

Low

892266

YFEZ
Inner membrane protein YfeZ

1

0

High-throughput

0.279

Low

892267

EUTK
Bacterial microcompartment shell protein EutK

1

0

High-throughput

0.279

Low

892268

EUTQ
Acetate kinase EutQ

1

0

High-throughput

0.279

Low

892269

EUTP
Probable acetate kinase EutP

1

0

High-throughput

0.279

Low

892279

TCDA
tRNA threonylcarbamoyladenosine dehydratase

1

0

High-throughput

0.279

Low

466703

EXBB
Biopolymer transport protein ExbB

1

0

High-throughput

0.261

Low

467509

LAPA
Lipopolysaccharide assembly protein A

1

0

High-throughput

0.261

Low

467862

YGGE
Uncharacterized protein YggE

1

0

High-throughput

0.261

Low

460097

PLSB
Glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.253

Low

462628

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.253

Low

463337

YACL
UPF0231 protein YacL

1

0

High-throughput

0.253

Low

463498

TRMB
tRNA

1

0

High-throughput

0.253

Low

473828

GATZ
D-tagatose-1,6-bisphosphate aldolase subunit GatZ

1

0

High-throughput

0.253

Low

621963

RP54
RNA polymerase sigma-54 factor

1

0

High-throughput

0.253

Low

633813

RIBD
Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase

1

0

High-throughput

0.253

Low

676798

3PASE
Inorganic triphosphatase

1

0

High-throughput

0.253

Low

892278

YGCP
Uncharacterized protein YgcP

1

0

High-throughput

0.253

Low

464088

YBGC
Acyl-CoA thioester hydrolase YbgC

1

0

High-throughput

0.249

Low

467680

NLPD
Murein hydrolase activator NlpD

1

0

High-throughput

0.249

Low

738163

YADG
Uncharacterized ABC transporter ATP-binding protein YadG

1

0

High-throughput

0.249

Low

761751

YJJU
Uncharacterized protein YjjU

1

0

High-throughput

0.249

Low

892248

YODD
Uncharacterized protein YodD

1

0

High-throughput

0.249

Low

892258

RLHA
23S rRNA 5-hydroxycytidine C2501 synthase

1

0

High-throughput

0.249

Low

892263

YEGH
UPF0053 protein YegH

1

0

High-throughput

0.249

Low

892273

GTRB
Prophage bactoprenol glucosyl transferase homolog

1

0

High-throughput

0.249

Low

892274

YBAY
Uncharacterized lipoprotein YbaY

1

0

High-throughput

0.249

Low

892271

YFCU
Putative outer membrane usher protein YfcU

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024