Protein: TCPA
T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)

Gene: TCPA, TCP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 153
UniProt ID: P12612

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005832 - chaperonin-containing T-complex
GO:0005886 - plasma membrane
GO:0006457 - protein folding
GO:0016887 - ATP hydrolysis activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

519942

TCPG
T-complex protein 1 subunit gamma

6

15

Small-scale

0.925

High

519941

TCPB
T-complex protein 1 subunit beta

3

17

Small-scale

0.857

High

519944

TCPZ
T-complex protein 1 subunit zeta

3

17

Small-scale

0.827

High

519943

TCPD
T-complex protein 1 subunit delta

2

16

Small-scale

0.754

High

519953

TCPE
T-complex protein 1 subunit epsilon

2

18

Small-scale

0.754

High

519959

TCPH
T-complex protein 1 subunit eta

2

16

Small-scale

0.754

High

519969

TCPQ
T-complex protein 1 subunit theta

2

16

Small-scale

0.754

High

519982

ACT
Actin

3

19

Small-scale

0.643

High

519984

2ABA
Protein phosphatase PP2A regulatory subunit B

3

20

High-throughput

0.609

High

519892

PP11
Serine/threonine-protein phosphatase PP1-1

3

20

High-throughput

0.593

High

519897

SIS1
Protein SIS1

2

3

High-throughput

0.584

High

520010

PLP2
Phosducin-like protein 2

2

17

Small-scale

0.584

High

520014

RIO1
Serine/threonine-protein kinase RIO1

2

5

High-throughput

0.584

High

519971

PFD3
Prefoldin subunit 3

1

3

Small-scale

0.575

High

519981

PFD4
Prefoldin subunit 4

1

2

Small-scale

0.575

High

519995

PFD5
Prefoldin subunit 5

1

2

Small-scale

0.575

High

519930

TAF5
Transcription initiation factor TFIID subunit 5

2

20

High-throughput

0.574

High

365677

HSP82
ATP-dependent molecular chaperone HSP82

2

13

High-throughput

0.571

High

519966

YPP1
Cargo-transport protein YPP1

2

0

High-throughput

0.563

High

519901

CDC20
APC/C activator protein CDC20

2

20

Small-scale

0.558

High

519928

CAF4
CCR4-associated factor 4

2

20

High-throughput

0.558

High

520016

WTM1
Transcriptional modulator WTM1

2

2

High-throughput

0.558

High

519921

DCA13
Protein SOF1

2

20

High-throughput

0.549

High

519973

PFD6
Prefoldin subunit 6

1

0

Small-scale

0.546

High

339390

CDK1
Cyclin-dependent kinase 1

1

12

High-throughput

0.536

High

412630

KAPA
cAMP-dependent protein kinase type 1

1

20

High-throughput

0.536

High

519891

GBB
Guanine nucleotide-binding protein subunit beta

1

20

High-throughput

0.536

High

519910

KNS1
Dual specificity protein kinase KNS1

1

10

High-throughput

0.536

High

519913

IME2
Meiosis induction protein kinase IME2/SME1

1

12

High-throughput

0.536

High

519914

RAD24
Checkpoint protein RAD24

1

2

High-throughput

0.536

High

519922

SIP2
SNF1 protein kinase subunit beta-2

1

3

High-throughput

0.536

High

519970

HGH1
Protein HGH1

2

2

Small-scale

0.533

High

520020

CMR1
DNA damage-binding protein CMR1

2

20

High-throughput

0.533

High

519896

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

2

20

High-throughput

0.521

High

519936

RPN1
26S proteasome regulatory subunit RPN1

2

4

High-throughput

0.521

High

519983

H3
Histone H3

2

6

High-throughput

0.521

High

519957

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.513

High

520008

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

High-throughput

0.513

High

519893

PWP1
Periodic tryptophan protein 1

1

20

High-throughput

0.489

High

519909

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

20

High-throughput

0.489

High

519938

SPT8
Transcription factor SPT8

1

2

High-throughput

0.489

High

519956

COPB2
Coatomer subunit beta'

1

15

High-throughput

0.489

High

519958

PFS2
Polyadenylation factor subunit 2

1

20

High-throughput

0.489

High

519979

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.489

High

519985

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.489

High

520011

RAD28
Radiation-sensitive protein 28

1

20

High-throughput

0.489

High

519888

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.479

High

519889

VATB
V-type proton ATPase subunit B

1

8

High-throughput

0.479

High

519900

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.479

High

519907

HS104
Heat shock protein 104

1

2

High-throughput

0.479

High

519911

HOG1
Mitogen-activated protein kinase HOG1

1

13

High-throughput

0.479

High

519918

PRS6A
26S proteasome regulatory subunit 6A

1

11

High-throughput

0.479

High

519972

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.479

High

519991

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.479

High

519992

PLP1
Phosducin-like protein 1

1

14

High-throughput

0.479

High

519993

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.479

High

520019

RUVB2
RuvB-like protein 2

1

5

High-throughput

0.479

High

520022

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

519998

CORO
Coronin-like protein

1

20

High-throughput

0.470

High

519917

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.457

High

519912

RPD3
Histone deacetylase RPD3

1

20

Small-scale

0.457

High

424254

CARA
Carbamoyl phosphate synthase arginine-specific small chain

1

1

High-throughput

0.445

High

430742

SYV
Valine--tRNA ligase, mitochondrial

1

1

High-throughput

0.445

High

490154

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

510062

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

519890

VATA
V-type proton ATPase catalytic subunit A

1

13

High-throughput

0.445

High

519924

DHR2
Probable ATP-dependent RNA helicase DHR2

1

1

High-throughput

0.445

High

519948

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

519950

RIO2
Serine/threonine-protein kinase RIO2

1

5

High-throughput

0.445

High

519951

ATAD2
ATPase histone chaperone YTA7

1

7

High-throughput

0.445

High

519977

INO80
Chromatin-remodeling ATPase INO80

1

2

High-throughput

0.445

High

519994

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.445

High

520001

SUB2
ATP-dependent RNA helicase SUB2

1

10

High-throughput

0.445

High

406719

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.437

High

407677

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

454144

TBA1
Tubulin alpha-1 chain

1

20

High-throughput

0.437

High

454538

TBA3
Tubulin alpha-3 chain

1

20

High-throughput

0.437

High

519887

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.437

High

519894

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.437

High

519898

SGF29
SAGA-associated factor 29

1

1

Small-scale

0.437

High

519899

KRR1
KRR1 small subunit processome component

1

2

High-throughput

0.437

High

519906

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.437

High

519908

EF2
Elongation factor 2

1

6

High-throughput

0.437

High

519915

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

519916

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

519925

CENPA
Histone H3-like centromeric protein CSE4

1

6

High-throughput

0.437

High

519929

GBLP
Small ribosomal subunit protein RACK1

1

20

Small-scale

0.437

High

519932

MAP2
Methionine aminopeptidase 2

1

5

High-throughput

0.437

High

519935

ARP1
Centractin

1

20

High-throughput

0.437

High

519937

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

17

Small-scale

0.437

High

519945

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

519947

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.437

High

519949

VID27
Vacuolar import and degradation protein 27

1

2

High-throughput

0.437

High

519960

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.437

High

519962

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

8

High-throughput

0.437

High

519968

MDV1
Mitochondrial division protein 1

1

20

High-throughput

0.437

High

519986

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.437

High

519988

BUL2
Ubiquitin ligase-binding protein BUL2

1

3

Small-scale

0.437

High

519990

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

519996

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.437

High

520004

SGO1
Shugoshin

1

2

High-throughput

0.437

High

520005

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.437

High

520006

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

519939

ATU2
Copper-transporting ATPase

1

0

High-throughput

0.426

High

519975

ACS2
Acetyl-coenzyme A synthetase 2

1

0

High-throughput

0.426

High

519999

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase

1

0

High-throughput

0.426

High

520018

GDIR
Rho GDP-dissociation inhibitor

1

0

High-throughput

0.426

High

356204

H4
Histone H4

1

1

High-throughput

0.407

High

367666

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.407

High

402858

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

4

High-throughput

0.407

High

410064

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

3

High-throughput

0.407

High

429602

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

8

High-throughput

0.407

High

519919

MED9
Mediator of RNA polymerase II transcription subunit 9

1

1

High-throughput

0.407

High

519955

SA185
SIT4-associating protein SAP185

1

1

High-throughput

0.407

High

519963

SAD1
Pre-mRNA-splicing factor SAD1

1

5

High-throughput

0.407

High

519976

HOS2
Probable histone deacetylase HOS2

1

20

High-throughput

0.407

High

519978

RT102
Regulator of Ty1 transposition protein 102

1

1

High-throughput

0.407

High

520000

CDC73
Cell division control protein 73

1

4

High-throughput

0.407

High

520002

RLP24
Ribosome biogenesis protein RLP24

1

1

High-throughput

0.407

High

520007

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.407

High

520017

RPN6
26S proteasome regulatory subunit RPN6

1

1

High-throughput

0.407

High

520021

SET6
Potential protein lysine methyltransferase SET6

1

2

High-throughput

0.407

High

519940

POP2
Poly(A) ribonuclease POP2

2

0

High-throughput

0.307

High

520003

YL030
Putative uncharacterized protein YLR030W

1

0

High-throughput

0.282

High

519904

YJU2
Splicing factor YJU2

1

0

High-throughput

0.279

Low

519931

RTG3
Retrograde regulation protein 3

1

0

High-throughput

0.279

Low

519987

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.265

Low

520012

HUA2
Protein HUA2

1

0

High-throughput

0.265

Low

519895

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.261

Low

519961

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.261

Low

519923

CENPC
Inner kinetochore subunit MIF2

1

0

High-throughput

0.251

Low

519927

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

519954

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

519974

NUP84
Nucleoporin NUP84

1

0

High-throughput

0.249

Low

520023

HPH1
Protein HPH1

1

0

High-throughput

0.238

Low

519902

RFA3
Replication factor A protein 3

1

0

High-throughput

0.232

Low

519903

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.232

Low

519905

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.232

Low

519920

MFT1
THO complex subunit MFT1

1

0

High-throughput

0.232

Low

519926

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

519933

CS111
F-box protein COS111

1

0

High-throughput

0.232

Low

519934

DPH7
Diphthine methyltransferase

1

0

High-throughput

0.232

Low

519946

NOC2
Nucleolar complex protein 2

1

0

High-throughput

0.232

Low

519952

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.232

Low

519964

LSB3
LAS seventeen-binding protein 3

1

0

High-throughput

0.232

Low

519965

STU2
Protein STU2

1

0

High-throughput

0.232

Low

519967

YJS1
UPF0508 protein YJL181W

1

0

High-throughput

0.232

Low

519980

NOG2
Nucleolar GTP-binding protein 2

1

0

High-throughput

0.232

Low

519989

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.232

Low

519997

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

0

High-throughput

0.232

Low

520009

DDC1
DNA damage checkpoint protein 1

1

0

High-throughput

0.232

Low

520013

RFM1
Repression factor of MSEs protein 1

1

0

High-throughput

0.232

Low

520015

DAD1
DASH complex subunit DAD1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024