Protein: SYKC
Lysine--tRNA ligase, cytoplasmic (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS)

Gene: SYKC, KRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P15180

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003729 - mRNA binding
GO:0003877 - ATP:ADP adenylyltransferase activity
GO:0004824 - lysine-tRNA ligase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

546188

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

5

High-throughput

0.640

High

546192

LSM1
Sm-like protein LSm1

2

1

High-throughput

0.621

High

389044

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

11

High-throughput

0.618

High

546169

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.618

High

546180

RV167
Reduced viability upon starvation protein 167

2

4

High-throughput

0.611

High

546146

CDC48
Cell division control protein 48

2

1

High-throughput

0.588

High

365711

HSP82
ATP-dependent molecular chaperone HSP82

2

6

High-throughput

0.584

High

367686

EF1A
Elongation factor 1-alpha

2

3

High-throughput

0.571

High

546135

PRP6
Pre-mRNA-splicing factor 6

1

3

High-throughput

0.536

High

546202

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

546206

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

8

High-throughput

0.536

High

546136

FKBP
FK506-binding protein 1

1

0

High-throughput

0.513

High

546140

KC11
Casein kinase I homolog 1

1

3

High-throughput

0.501

High

546141

KC12
Casein kinase I homolog 2

1

3

High-throughput

0.501

High

546211

STE20
Serine/threonine-protein kinase STE20

1

3

High-throughput

0.501

High

546197

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.480

High

343800

SYMC
Methionine--tRNA ligase, cytoplasmic

1

13

High-throughput

0.479

High

367525

EFTU
Elongation factor Tu, mitochondrial

1

9

High-throughput

0.479

High

388939

SYTC
Threonine--tRNA ligase, cytoplasmic

1

8

High-throughput

0.479

High

410293

SC160
Protein SCP160

1

2

High-throughput

0.479

High

422984

TOM70
Mitochondrial import receptor subunit TOM70

1

7

High-throughput

0.479

High

425062

SYH
Histidine--tRNA ligase, mitochondrial

1

3

High-throughput

0.479

High

430745

SYV
Valine--tRNA ligase, mitochondrial

1

9

High-throughput

0.479

High

482820

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

524134

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

526320

SYQ
Glutamine--tRNA ligase

1

11

High-throughput

0.479

High

546133

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

546137

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

3

High-throughput

0.479

High

546138

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

2

High-throughput

0.479

High

546142

IF5A1
Eukaryotic translation initiation factor 5A-1

1

5

High-throughput

0.479

High

546143

IF2M
Translation initiation factor IF-2, mitochondrial

1

8

High-throughput

0.479

High

546144

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

546145

RBSK
Ribokinase

1

2

High-throughput

0.479

High

546147

SYLC
Leucine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

546148

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

546149

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

546150

EF1G1
Elongation factor 1-gamma 1

1

7

High-throughput

0.479

High

546151

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

546152

SP110
Spindle pole body component 110

1

4

High-throughput

0.479

High

546153

MET4
Transcriptional activator of sulfur metabolism MET4

1

2

High-throughput

0.479

High

546154

ZUO1
Zuotin

1

5

High-throughput

0.479

High

546155

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.479

High

546156

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

2

High-throughput

0.479

High

546157

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

546158

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.479

High

546159

SPC29
Spindle pole component 29

1

1

High-throughput

0.479

High

546161

EF1G2
Elongation factor 1-gamma 2

1

6

High-throughput

0.479

High

546162

SPC42
Spindle pole body component SPC42

1

2

High-throughput

0.479

High

546163

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

546164

AHP1
Peroxiredoxin AHP1

1

1

High-throughput

0.479

High

546165

RM16
Large ribosomal subunit protein uL16m

1

2

High-throughput

0.479

High

546166

SYG
Glycine--tRNA ligase 1, mitochondrial

1

10

High-throughput

0.479

High

546170

YHI0
Putative proline--tRNA ligase YHR020W

1

9

High-throughput

0.479

High

546172

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.479

High

546173

SSZ1
Ribosome-associated complex subunit SSZ1

1

4

High-throughput

0.479

High

546174

RPN10
26S proteasome regulatory subunit RPN10

1

2

High-throughput

0.479

High

546176

ATU2
Copper-transporting ATPase

1

2

High-throughput

0.479

High

546177

CAJ1
Protein CAJ1

1

2

High-throughput

0.479

High

546178

DHH1
ATP-dependent RNA helicase DHH1

1

3

High-throughput

0.479

High

546179

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

546183

CCS1
Superoxide dismutase 1 copper chaperone

1

3

High-throughput

0.479

High

546184

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

2

High-throughput

0.479

High

546185

MMM1
Maintenance of mitochondrial morphology protein 1

1

2

High-throughput

0.479

High

546186

GCN20
Protein GCN20

1

5

High-throughput

0.479

High

546189

LSB3
LAS seventeen-binding protein 3

1

5

High-throughput

0.479

High

546190

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

546191

ARC1
tRNA-aminoacylation cofactor ARC1

1

6

High-throughput

0.479

High

546193

DENR
Translation machinery-associated protein 22

1

2

High-throughput

0.479

High

546194

HOSC
Homocitrate synthase, cytosolic isozyme

1

2

High-throughput

0.479

High

546198

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

3

High-throughput

0.479

High

546199

LSB1
LAS seventeen-binding protein 1

1

5

High-throughput

0.479

High

546200

SPC98
Spindle pole body component SPC98

1

2

High-throughput

0.479

High

546201

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

2

High-throughput

0.479

High

546203

SYC
Cysteine--tRNA ligase

1

6

High-throughput

0.479

High

546204

PDR16
Phosphatidylinositol transfer protein PDR16

1

2

High-throughput

0.479

High

546205

TMA20
Translation machinery-associated protein 20

1

2

High-throughput

0.479

High

546207

MAP1
Methionine aminopeptidase 1

1

2

High-throughput

0.479

High

546208

ESP1
Separin

1

1

High-throughput

0.479

High

546209

RLI1
Translation initiation factor RLI1

1

7

High-throughput

0.479

High

546210

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

546213

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

546215

RPN9
26S proteasome regulatory subunit RPN9

1

1

High-throughput

0.479

High

546216

RM34
Large ribosomal subunit protein bL34m

1

2

High-throughput

0.479

High

546218

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

546219

LAM6
Membrane-anchored lipid-binding protein LAM6

1

1

High-throughput

0.479

High

546221

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

2

High-throughput

0.479

High

546224

TRMB
tRNA

1

2

High-throughput

0.479

High

546225

MLH3
DNA mismatch repair protein MLH3

1

2

High-throughput

0.479

High

546226

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

546228

MDY2
Ubiquitin-like protein MDY2

1

2

High-throughput

0.479

High

546230

RKM4
Ribosomal lysine N-methyltransferase 4

1

2

High-throughput

0.479

High

546231

MED11
Mediator of RNA polymerase II transcription subunit 11

1

2

High-throughput

0.479

High

339407

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

546139

ATP12
Protein ATP12, mitochondrial

1

0

High-throughput

0.458

High

546160

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.458

High

546168

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

546195

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

546214

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

546217

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.458

High

546227

MDM32
Mitochondrial distribution and morphology protein 32

1

0

High-throughput

0.458

High

546182

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.445

High

546134

IF5A2
Eukaryotic translation initiation factor 5A-2

1

5

High-throughput

0.437

High

546175

SEC31
Protein transport protein SEC31

1

8

High-throughput

0.437

High

546181

SIT1
Siderophore iron transporter 1

1

6

High-throughput

0.437

High

546187

EMP47
Protein EMP47

1

1

High-throughput

0.437

High

546212

YMC0
Uncharacterized protein YML020W

1

2

High-throughput

0.437

High

546220

ENB1
Siderophore iron transporter ENB1

1

6

High-throughput

0.437

High

546222

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

546229

EMC6
ER membrane protein complex subunit 6

1

2

High-throughput

0.437

High

546223

TFB4
General transcription and DNA repair factor IIH subunit TFB4

2

0

High-throughput

0.324

High

546167

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

546171

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

546196

TPN1
Vitamin B6 transporter TPN1

1

0

High-throughput

0.249

Low

546232

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024