Protein: ACVL1
Serine/threonine-protein kinase receptor R3 (SKR3) (EC 2.7.11.30) (Activin receptor-like kinase 1) (ALK-1) (TGF-B superfamily receptor type I) (TSR-I)

Gene: ACVL1, ACVRL1
Organism: Homo sapiens
Interactions: 27
UniProt ID: P37023

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001666 - response to hypoxia
GO:0001701 - in utero embryonic development
GO:0001936 - regulation of endothelial cell proliferation
GO:0001937 - negative regulation of endothelial cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

739526

ACVR1
Activin receptor type-1

3

19

High-throughput

0.861

High

739520

TGFR2
TGF-beta receptor type-2

3

20

Small-scale

0.847

High

738505

TGFR1
TGF-beta receptor type-1

2

19

Small-scale

0.776

High

646020

AVR2A
Activin receptor type-2A

2

20

Small-scale

0.754

High

571091

EGLN
Endoglin

6

12

Small-scale

0.733

High

351288

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

4

20

Small-scale

0.676

High

739535

GDF2
Growth/differentiation factor 2

3

20

Small-scale

0.655

High

362648

A2GL
Leucine-rich alpha-2-glycoprotein

1

20

Small-scale

0.646

High

739529

SMAD1
Mothers against decapentaplegic homolog 1

2

20

Small-scale

0.602

High

739521

NR1H2
Oxysterols receptor LXR-beta

1

2

Small-scale

0.586

High

739522

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

7

Small-scale

0.555

High

739523

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.549

High

739525

TGBR3
Transforming growth factor beta receptor type 3

1

12

Small-scale

0.515

High

739532

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.504

High

739527

BAMBI
BMP and activin membrane-bound inhibitor homolog

1

5

Small-scale

0.501

High

739530

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

1

High-throughput

0.489

High

431606

HS90A
Heat shock protein HSP 90-alpha

1

15

Small-scale

0.479

High

439883

INHBA
Inhibin beta A chain

1

20

Small-scale

0.479

High

443048

ITA5
Integrin alpha-5

1

4

Small-scale

0.479

High

495652

TGFB3
Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide

1

20

Small-scale

0.479

High

739524

CAV1
Caveolin-1

1

6

Small-scale

0.479

High

739528

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.479

High

739533

IGSF1
Immunoglobulin superfamily member 1

1

7

Small-scale

0.479

High

739536

SNX6
Sorting nexin-6

1

8

Small-scale

0.437

High

739531

PDXD2
Putative pyridoxal-dependent decarboxylase domain-containing protein 2

2

0

High-throughput

0.298

High

416942

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.292

High

739534

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024