Protein: NDC80
Kinetochore protein NDC80 (80 kDa spindle component protein) (Nuclear division cycle protein 80) (Two-hybrid interaction with DMC1 protein 3)

Gene: NDC80
Organism: Saccharomyces cerevisiae S288C
Interactions: 119
UniProt ID: P40460

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000779 - condensed chromosome, centromeric region
GO:0005634 - nucleus
GO:0007059 - chromosome segregation
GO:0031262 - Ndc80 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

708008

NUF2
Kinetochore protein NUF2

28

18

Small-scale

0.993

High

774076

SPC24
Kinetochore protein SPC24

27

0

Small-scale

0.941

High

774045

NDC80
Kinetochore protein NDC80

2

15

Small-scale

0.781

High

774067

MPS1
Serine/threonine-protein kinase MPS1

7

20

Small-scale

0.751

High

766787

SPC25
Kinetochore protein SPC25

14

0

Small-scale

0.730

High

774046

DSN1
Kinetochore-associated protein DSN1

15

0

Small-scale

0.728

High

774062

DAM1
DASH complex subunit DAM1

11

0

Small-scale

0.725

High

774049

STU2
Protein STU2

4

9

Small-scale

0.696

High

763937

MTW1
Kinetochore-associated protein MTW1

4

1

Small-scale

0.689

High

733406

SPC34
DASH complex subunit SPC34

6

0

Small-scale

0.686

High

758787

IPL1
Spindle assembly checkpoint kinase

3

20

Small-scale

0.667

High

728361

ASK1
DASH complex subunit ASK1

4

0

Small-scale

0.648

High

774059

SP105
Spindle pole body component SPC105

2

1

Small-scale

0.635

High

774047

CENPT
Inner kinetochore subunit CNN1

3

0

Small-scale

0.634

High

491434

HSP71
Heat shock protein SSA1

3

13

Small-scale

0.633

High

494136

HSP72
Heat shock protein SSA2

3

13

Small-scale

0.624

High

774052

NNF1
Kinetochore-associated protein NNF1

3

0

High-throughput

0.621

High

774074

SPC19
DASH complex subunit SPC19

3

0

Small-scale

0.614

High

706016

NIP80
Protein NIP100

2

18

High-throughput

0.595

High

454355

TBA1
Tubulin alpha-1 chain

2

4

Small-scale

0.585

High

774091

DAD1
DASH complex subunit DAD1

2

0

Small-scale

0.576

High

758745

SMC2
Structural maintenance of chromosomes protein 2

1

9

Small-scale

0.573

High

628139

SIS1
Protein SIS1

2

5

Small-scale

0.571

High

694827

HSP7F
Heat shock protein homolog SSE1

2

17

Small-scale

0.571

High

774075

KRE28
Spindle pole body component KRE28

2

0

High-throughput

0.570

High

774073

FIN1
Filament protein FIN1

2

0

Small-scale

0.561

High

605657

KIN3
Serine/threonine-protein kinase KIN3

1

20

Small-scale

0.561

High

748280

CENPU
Inner kinetochore subunit AME1

2

0

Small-scale

0.559

High

774070

HSK3
DASH complex subunit HSK3

2

0

Small-scale

0.552

High

697944

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

8

High-throughput

0.541

High

649970

BUD14
Bud site selection protein 14

1

0

High-throughput

0.536

High

774050

BBC1
Myosin tail region-interacting protein MTI1

1

10

High-throughput

0.512

High

774088

MSH5
MutS protein homolog 5

1

1

High-throughput

0.508

High

655037

CIN8
Kinesin-like protein CIN8

1

20

Small-scale

0.501

High

774051

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

20

High-throughput

0.501

High

743154

BOB1
Protein BOB1

1

9

High-throughput

0.494

High

753630

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

20

High-throughput

0.494

High

755632

BZZ1
Protein BZZ1

1

11

High-throughput

0.494

High

765843

BOI2
Protein BOI2

1

12

High-throughput

0.494

High

774077

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.493

High

566602

VATA
V-type proton ATPase catalytic subunit A

1

5

High-throughput

0.489

High

774064

ARPC2
Actin-related protein 2/3 complex subunit 2

1

1

High-throughput

0.489

High

774078

YL456
Pyridoxamine 5'-phosphate oxidase YLR456W homolog

1

0

High-throughput

0.486

High

774079

ATG17
Autophagy-related protein 17

1

0

High-throughput

0.486

High

774087

CUB1

1

0

High-throughput

0.486

High

774094

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.486

High

632532

DMC1
Meiotic recombination protein DMC1

1

3

Small-scale

0.481

High

688526

KNS1
Dual specificity protein kinase KNS1

1

14

High-throughput

0.481

High

704211

CNS1
Hsp70/Hsp90 co-chaperone CNS1

1

6

Small-scale

0.481

High

774055

UBC9
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.481

High

774058

MCM6
DNA replication licensing factor MCM6

1

13

Small-scale

0.481

High

774084

ADY3
Accumulates dyads protein 3

1

17

High-throughput

0.481

High

774090

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

High-throughput

0.481

High

774093

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.481

High

558094

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

662415

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

688770

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

15

High-throughput

0.479

High

693123

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

16

Small-scale

0.479

High

694070

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

9

High-throughput

0.479

High

696346

PP12
Serine/threonine-protein phosphatase PP1-2

1

16

Small-scale

0.479

High

774089

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

743459

YPK3
Serine/threonine-protein kinase YPK3

1

16

High-throughput

0.470

High

774095

YD199
Putative metabolite transport protein YDL199C

1

1

High-throughput

0.470

High

613063

SPA2
Protein SPA2

1

9

High-throughput

0.464

High

687790

MSB2
Signaling mucin MSB2

1

7

High-throughput

0.464

High

690539

CDC12
Cell division control protein 12

1

8

High-throughput

0.464

High

452104

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.460

High

693406

SMI1
Cell wall assembly regulator SMI1

1

0

Small-scale

0.460

High

698550

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

Small-scale

0.460

High

774057

UFD1
Ubiquitin fusion degradation protein 1

1

0

High-throughput

0.460

High

774065

NIS1
Protein NIS1

1

0

High-throughput

0.460

High

774096

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.460

High

774061

YBP2
YAP1-binding protein 2

1

0

Small-scale

0.458

High

774072

CENPP
Inner kinetochore subunit CTF19

1

0

Small-scale

0.458

High

774080

CENPO
Inner kinetochore subunit MCM21

1

0

Small-scale

0.458

High

774086

SGO1
Shugoshin

1

0

High-throughput

0.458

High

450067

HSP73
Heat shock protein SSA3

1

13

High-throughput

0.445

High

511567

SSB1
Ribosome-associated molecular chaperone SSB1

1

13

High-throughput

0.445

High

689263

SP110
Spindle pole body component 110

1

17

Small-scale

0.445

High

768598

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

774056

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.445

High

731322

DYHC
Dynein heavy chain, cytoplasmic

1

9

High-throughput

0.439

High

759229

END3
Actin cytoskeleton-regulatory complex protein END3

1

18

High-throughput

0.439

High

774054

KEL2
Kelch repeat-containing protein 2

1

17

High-throughput

0.439

High

691323

NGG1
Chromatin-remodeling complexes subunit NGG1

1

0

High-throughput

0.438

High

697695

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

High-throughput

0.438

High

586156

PMA2
Plasma membrane ATPase 2

1

3

High-throughput

0.437

High

760747

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.437

High

774085

UBR2
E3 ubiquitin-protein ligase UBR2

1

2

Small-scale

0.437

High

734063

DAD2
DASH complex subunit DAD2

1

0

Small-scale

0.426

High

747512

CENPL
Inner kinetochore subunit IML3

1

0

High-throughput

0.426

High

774060

DUO1
DASH complex subunit DUO1

1

0

Small-scale

0.426

High

774068

DAD3
DASH complex subunit DAD3

1

0

Small-scale

0.426

High

774069

DAD4
DASH complex subunit DAD4

1

0

Small-scale

0.426

High

774092

CENPH
Inner kinetochore subunit MCM16

1

0

High-throughput

0.426

High

774097

CENPI
Inner kinetochore subunit CTF3

1

0

High-throughput

0.426

High

774098

CENPW
Inner kinetochore subunit WIP1

1

0

High-throughput

0.426

High

360905

TBB
Tubulin beta chain

1

2

Small-scale

0.407

High

368124

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.407

High

705255

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

766042

HSP7E
Heat shock protein SSC3, mitochondrial

1

14

High-throughput

0.407

High

774053

HLJ1
Protein HLJ1

1

10

High-throughput

0.407

High

774081

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

8

High-throughput

0.407

High

746734

FL2D
Protein MUM2

2

0

High-throughput

0.310

High

767885

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.282

High

774071

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.282

High

710338

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.279

Low

747616

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.279

Low

774066

VAC7
Vacuolar segregation protein 7

1

0

High-throughput

0.269

Low

774063

COG2
Conserved oligomeric Golgi complex subunit 2

1

0

High-throughput

0.265

Low

563961

SEC2
Rab guanine nucleotide exchange factor SEC2

1

0

High-throughput

0.251

Low

734310

JNM1
Nuclear migration protein JNM1

1

0

High-throughput

0.251

Low

741301

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.251

Low

766488

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.251

Low

774099

HPH1
Protein HPH1

1

0

High-throughput

0.251

Low

774082

FMP45
SUR7 family protein FMP45

1

0

High-throughput

0.249

Low

774083

HBT1
Protein HBT1

1

0

High-throughput

0.249

Low

774048

FAR3
Factor arrest protein 3

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024