Protein: MED6
Mediator of RNA polymerase II transcription subunit 6 (Mediator complex subunit 6)

Gene: MED6
Organism: Saccharomyces cerevisiae S288C
Interactions: 48
UniProt ID: P38782

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

693535

MED17
Mediator of RNA polymerase II transcription subunit 17

20

0

Small-scale

0.938

High

748101

MED8
Mediator of RNA polymerase II transcription subunit 8

6

1

Small-scale

0.932

High

626029

MED19
Mediator of RNA polymerase II transcription subunit 19

6

0

Small-scale

0.887

High

693588

MED22
Mediator of RNA polymerase II transcription subunit 22

5

0

Small-scale

0.872

High

754286

MED10
Mediator of RNA polymerase II transcription subunit 10

3

4

Small-scale

0.843

High

754292

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

Small-scale

0.831

High

375381

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

3

Small-scale

0.817

High

581361

MED14
Mediator of RNA polymerase II transcription subunit 14

9

3

Small-scale

0.749

High

754287

MED7
Mediator of RNA polymerase II transcription subunit 7

8

4

Small-scale

0.744

High

693920

MED18
Mediator of RNA polymerase II transcription subunit 18

10

0

Small-scale

0.720

High

751460

MED31
Mediator of RNA polymerase II transcription subunit 31

4

3

High-throughput

0.676

High

754277

MED3
Mediator of RNA polymerase II transcription subunit 3

5

0

Small-scale

0.670

High

419874

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.663

High

754283

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.657

High

754282

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.652

High

586302

MED15
Mediator of RNA polymerase II transcription subunit 15

4

0

Small-scale

0.649

High

704150

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.648

High

710262

MED20
Mediator of RNA polymerase II transcription subunit 20

4

0

Small-scale

0.638

High

754291

MED1
Mediator of RNA polymerase II transcription subunit 1

3

0

High-throughput

0.634

High

754273

SSN3
Meiotic mRNA stability protein kinase SSN3

1

3

High-throughput

0.618

High

754288

MED2
Mediator of RNA polymerase II transcription subunit 2

3

0

High-throughput

0.616

High

751017

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.586

High

558043

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

2

Small-scale

0.584

High

754290

RIO1
Serine/threonine-protein kinase RIO1

2

1

High-throughput

0.571

High

662147

TF2B
Transcription initiation factor IIB

2

0

High-throughput

0.551

High

440029

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.536

High

587848

AP1
AP-1-like transcription factor YAP1

1

0

High-throughput

0.513

High

381544

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.480

High

754274

IFH1
Protein IFH1

1

0

Small-scale

0.480

High

754279

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.479

High

687693

BTAF1
TATA-binding protein-associated factor MOT1

1

2

Small-scale

0.479

High

754281

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

2

High-throughput

0.479

High

754275

SPC25
Kinetochore protein SPC25

1

0

High-throughput

0.460

High

686845

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.458

High

715678

TAF14
Transcription initiation factor TFIID subunit 14

1

0

High-throughput

0.458

High

728232

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

754272

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.458

High

754289

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

754293

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

511220

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

754276

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

754285

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.445

High

754284

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.417

High

634052

DCC1
Sister chromatid cohesion protein DCC1

2

0

Small-scale

0.295

High

754278

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

632566

RAD51
DNA repair protein RAD51

1

0

High-throughput

0.269

Low

746826

TRM7
tRNA

1

0

High-throughput

0.238

Low

754280

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024