Protein: THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20 (EC 2.7.1.49) (EC 2.7.4.7) (EC 3.5.99.2) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase)

Gene: THI20
Organism: Saccharomyces cerevisiae S288C
Interactions: 109
UniProt ID: Q08224

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0008902 - hydroxymethylpyrimidine kinase activity
GO:0008972 - phosphomethylpyrimidine kinase activity
GO:0009228 - thiamine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

412596

CDC7
Cell division control protein 7

1

1

High-throughput

0.500

High

419755

RHO2
GTP-binding protein RHO2

1

1

High-throughput

0.500

High

420521

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

High-throughput

0.500

High

500339

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

1

High-throughput

0.500

High

539282

YAK1
Dual specificity protein kinase YAK1

1

2

High-throughput

0.500

High

539417

KSS1
Mitogen-activated protein kinase KSS1

1

1

High-throughput

0.500

High

605592

DBF2
Cell cycle protein kinase DBF2

1

2

High-throughput

0.500

High

614834

KC11
Casein kinase I homolog 1

1

3

High-throughput

0.500

High

628835

RAD57
DNA repair protein RAD57

1

1

High-throughput

0.500

High

688543

KNS1
Dual specificity protein kinase KNS1

1

2

High-throughput

0.500

High

693753

IME2
Meiosis induction protein kinase IME2/SME1

1

1

High-throughput

0.500

High

697311

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.500

High

699414

RAD54
DNA repair and recombination protein RAD54

1

3

High-throughput

0.500

High

703858

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.500

High

750802

MSG5
Tyrosine-protein phosphatase MSG5

1

1

High-throughput

0.500

High

753191

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.500

High

757825

MLH1
DNA mismatch repair protein MLH1

1

1

High-throughput

0.500

High

772492

RAD26
DNA repair and recombination protein RAD26

1

3

High-throughput

0.500

High

774626

PRK1
Actin-regulating kinase PRK1

1

1

High-throughput

0.500

High

854621

UBC13
Ubiquitin-conjugating enzyme E2 13

1

2

High-throughput

0.500

High

854631

UBC11
Ubiquitin-conjugating enzyme E2-18 kDa

1

2

High-throughput

0.500

High

863698

PAP2
Poly(A) RNA polymerase protein 2

1

1

High-throughput

0.500

High

961933

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

High-throughput

0.500

High

976908

TDA1
Serine/threonine-protein kinase TDA1

1

1

High-throughput

0.500

High

994434

YP150
Putative serine/threonine-protein kinase YPL150W

1

3

High-throughput

0.500

High

994438

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.500

High

389660

DNLI1
DNA ligase 1

1

0

High-throughput

0.479

High

549842

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.479

High

606157

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.479

High

629669

RV161
Reduced viability upon starvation protein 161

1

0

High-throughput

0.479

High

690563

CDC12
Cell division control protein 12

1

0

High-throughput

0.479

High

691216

MKK1
MAP kinase kinase MKK1/SSP32

1

0

High-throughput

0.479

High

748397

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.479

High

751293

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.479

High

758761

SMC2
Structural maintenance of chromosomes protein 2

1

0

High-throughput

0.479

High

761515

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.479

High

775021

YRB2
Ran-specific GTPase-activating protein 2

1

0

High-throughput

0.479

High

798343

TOS3
Serine/threonine-protein kinase TOS3

1

0

High-throughput

0.479

High

858956

BOL2
BolA-like protein 2

1

0

High-throughput

0.479

High

979556

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.479

High

994435

GET3
ATPase GET3

1

0

High-throughput

0.479

High

994437

PKH2
Serine/threonine-protein kinase PKH2

1

0

High-throughput

0.479

High

994439

YPT6
GTP-binding protein YPT6

1

0

High-throughput

0.479

High

628535

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

994433

MLH3
DNA mismatch repair protein MLH3

1

1

High-throughput

0.479

High

698965

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

715659

SGS1
ATP-dependent helicase SGS1

1

0

High-throughput

0.458

High

979176

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

419638

RAD52
DNA repair and recombination protein RAD52

1

1

High-throughput

0.457

High

429780

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

516919

SIR4
Regulatory protein SIR4

1

1

High-throughput

0.457

High

644830

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

657773

YJU2
Splicing factor YJU2

1

1

High-throughput

0.457

High

688130

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

2

High-throughput

0.457

High

733010

HEL1
E3 ubiquitin-protein ligase HEL1

1

1

High-throughput

0.457

High

758715

TEM1
Protein TEM1

1

2

High-throughput

0.457

High

765414

RSP5
E3 ubiquitin-protein ligase RSP5

1

1

High-throughput

0.457

High

961501

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.457

High

971773

MEC3
DNA damage checkpoint control protein MEC3

1

1

High-throughput

0.457

High

977829

YD131
F-box protein YDR131C

1

1

High-throughput

0.457

High

988541

OMS1
Methyltransferase OMS1, mitochondrial

1

2

High-throughput

0.457

High

991150

PRP11
Pre-mRNA-splicing factor PRP11

1

2

High-throughput

0.457

High

994428

DIA2
Protein DIA2

1

1

High-throughput

0.457

High

994430

CDC53
Cell division control protein 53

1

3

High-throughput

0.457

High

994431

RAD28
Radiation-sensitive protein 28

1

1

High-throughput

0.457

High

994436

PSH1
RING finger protein PSH1

1

1

High-throughput

0.457

High

492642

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

695666

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

979521

PANK
Pantothenate kinase CAB1

1

0

High-throughput

0.438

High

663506

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

663924

TF3B
Transcription factor IIIB 70 kDa subunit

1

3

High-throughput

0.437

High

393904

PHR
Deoxyribodipyrimidine photo-lyase, mitochondrial

1

0

High-throughput

0.261

Low

419399

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.261

Low

419579

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

420444

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.261

Low

436849

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.261

Low

524466

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.261

Low

539935

RAD9
DNA repair protein RAD9

1

0

High-throughput

0.261

Low

550579

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.261

Low

594149

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.261

Low

624319

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

635976

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.261

Low

696417

PP12
Serine/threonine-protein phosphatase PP1-2

1

0

High-throughput

0.261

Low

704006

XRS2
DNA repair protein XRS2

1

0

High-throughput

0.261

Low

744706

TAF5
Transcription initiation factor TFIID subunit 5

1

0

High-throughput

0.261

Low

746165

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.261

Low

748422

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.261

Low

755807

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

0

High-throughput

0.261

Low

756802

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.261

Low

765620

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.261

Low

772691

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.261

Low

791155

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.261

Low

805098

NUP85
Nucleoporin NUP85

1

0

High-throughput

0.261

Low

811155

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.261

Low

853186

SKP1
Suppressor of kinetochore protein 1

1

0

High-throughput

0.261

Low

860057

CDH1
APC/C activator protein CDH1

1

0

High-throughput

0.261

Low

861259

RBG2
Ribosome-interacting GTPase 2

1

0

High-throughput

0.261

Low

974367

COFI
Cofilin

1

0

High-throughput

0.261

Low

978493

POLH
DNA polymerase eta

1

0

High-throughput

0.261

Low

980198

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

986760

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.261

Low

987350

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.261

Low

994429

DDC1
DNA damage checkpoint protein 1

1

0

High-throughput

0.261

Low

606772

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

700751

ATO2
Ammonia transport outward protein 2

1

0

High-throughput

0.249

Low

764588

EXO1
Exodeoxyribonuclease 1

1

0

High-throughput

0.249

Low

775275

ULP2
Ubiquitin-like-specific protease 2

1

0

Small-scale

0.249

Low

987056

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

994432

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024