Protein: EXOS5
Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B)

Gene: EXOS5, EXOSC5
Organism: Homo sapiens
Interactions: 155
UniProt ID: Q9NQT4

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000791 - euchromatin

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1343598

EXOS1
Exosome complex component CSL4

15

20

Small-scale

0.989

High

1284980

EXOS8
Exosome complex component RRP43

13

19

Small-scale

0.984

High

1063771

EXOS7
Exosome complex component RRP42

5

19

High-throughput

0.932

High

1257154

DI3L1
DIS3-like exonuclease 1

4

20

Small-scale

0.909

High

1342612

EXOS4
Exosome complex component RRP41

4

19

Small-scale

0.909

High

1046346

EXOS2
Exosome complex component RRP4

4

20

Small-scale

0.900

High

986727

EXOS9
Exosome complex component RRP45

3

19

High-throughput

0.871

High

1130058

EXOS6
Exosome complex component MTR3

3

19

High-throughput

0.871

High

1343581

EXOS3
Exosome complex component RRP40

10

13

Small-scale

0.758

High

966489

EXOSX
Exosome complex component 10

7

11

Small-scale

0.747

High

1047040

C1D
Nuclear nucleic acid-binding protein C1D

4

4

High-throughput

0.704

High

1343603

RBM7
RNA-binding protein 7

4

6

High-throughput

0.704

High

1343591

IKZF3
Zinc finger protein Aiolos

4

1

High-throughput

0.698

High

1304449

MPH6
M-phase phosphoprotein 6

4

6

Small-scale

0.696

High

1343596

RRP44
Exosome complex exonuclease RRP44

1

20

Small-scale

0.691

High

981741

REL
Proto-oncogene c-Rel

3

1

High-throughput

0.675

High

1036357

BIRC2
Baculoviral IAP repeat-containing protein 2

3

2

High-throughput

0.675

High

1045945

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

3

1

High-throughput

0.675

High

1317455

TRI54
Tripartite motif-containing protein 54

3

6

High-throughput

0.675

High

787019

MTREX
Exosome RNA helicase MTR4

3

15

High-throughput

0.675

High

1343600

HBS1L
HBS1-like protein

3

5

Small-scale

0.670

High

147191

FCHO1
F-BAR domain only protein 1

3

2

High-throughput

0.667

High

1071410

K1H1
Keratin, type I cuticular Ha1

3

5

High-throughput

0.654

High

1343588

TFP11
Tuftelin-interacting protein 11

3

2

High-throughput

0.654

High

230432

ZC3H1
Zinc finger C3H1 domain-containing protein

2

6

High-throughput

0.628

High

908169

RS16
Small ribosomal subunit protein uS9

2

2

High-throughput

0.628

High

1157907

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

4

High-throughput

0.628

High

1167990

GGYF2
GRB10-interacting GYF protein 2

2

4

High-throughput

0.628

High

1218381

WDR75
WD repeat-containing protein 75

2

13

High-throughput

0.628

High

1198479

PEG10
Retrotransposon-derived protein PEG10

3

0

High-throughput

0.626

High

61880

CC88B
Coiled-coil domain-containing protein 88B

2

2

High-throughput

0.606

High

280730

KRT34
Keratin, type I cuticular Ha4

2

5

High-throughput

0.606

High

360667

SPTA1
Spectrin alpha chain, erythrocytic 1

2

1

High-throughput

0.606

High

1039867

SNW1
SNW domain-containing protein 1

2

3

High-throughput

0.606

High

1040954

MTMR3
Myotubularin-related protein 3

2

2

High-throughput

0.606

High

1108938

ZN792
Zinc finger protein 792

2

1

High-throughput

0.606

High

1169357

ZN620
Zinc finger protein 620

2

1

High-throughput

0.606

High

1189664

K1C27
Keratin, type I cytoskeletal 27

2

5

High-throughput

0.606

High

1236847

ZN655
Zinc finger protein 655

2

1

High-throughput

0.606

High

1257168

ZFP90
Zinc finger protein 90 homolog

2

1

High-throughput

0.606

High

1262333

PIHD2
PIH1 domain-containing protein 2

2

1

High-throughput

0.606

High

1263866

ACO11
Acyl-coenzyme A thioesterase 11

2

1

High-throughput

0.606

High

1264764

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

2

1

High-throughput

0.606

High

1270309

KRT35
Keratin, type I cuticular Ha5

2

5

High-throughput

0.606

High

1287671

DDT4L
DNA damage-inducible transcript 4-like protein

2

1

High-throughput

0.606

High

1310167

LZTS2
Leucine zipper putative tumor suppressor 2

2

2

High-throughput

0.606

High

1343582

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

1

High-throughput

0.606

High

1297718

DMRTB
Doublesex- and mab-3-related transcription factor B1

2

1

High-throughput

0.584

High

434503

FUMH
Fumarate hydratase, mitochondrial

2

0

High-throughput

0.580

High

446919

HXC4
Homeobox protein Hox-C4

2

0

High-throughput

0.580

High

993618

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1251653

ZN420
Zinc finger protein 420

2

0

High-throughput

0.580

High

1264341

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

0

High-throughput

0.580

High

1301560

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

1313761

TRI62
E3 ubiquitin-protein ligase TRIM62

2

0

High-throughput

0.580

High

1343584

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1025565

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.573

High

370504

ESR1
Estrogen receptor

2

12

High-throughput

0.571

High

314530

LCA5L
Lebercilin-like protein

2

1

High-throughput

0.553

High

1244081

DOCK8
Dedicator of cytokinesis protein 8

1

0

High-throughput

0.549

High

237322

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

4

High-throughput

0.536

High

418699

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

969546

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

1

High-throughput

0.536

High

1016331

TBL3
Transducin beta-like protein 3

1

14

High-throughput

0.536

High

1042609

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1067247

WDR43
WD repeat-containing protein 43

1

12

High-throughput

0.536

High

1070043

PWP2
Periodic tryptophan protein 2 homolog

1

11

High-throughput

0.536

High

1086391

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

1

High-throughput

0.536

High

1256128

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

9

High-throughput

0.536

High

1263551

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1282717

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

8

High-throughput

0.536

High

1326850

AICDA
Single-stranded DNA cytosine deaminase

1

6

Small-scale

0.536

High

1343585

GNL3L
Guanine nucleotide-binding protein-like 3-like protein

1

1

High-throughput

0.536

High

1343586

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.536

High

1343589

ZO2
Tight junction protein ZO-2

1

1

High-throughput

0.536

High

1343593

WDR3
WD repeat-containing protein 3

1

17

High-throughput

0.536

High

1343594

SRPK3
SRSF protein kinase 3

1

1

High-throughput

0.536

High

995240

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.523

High

1030125

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.518

High

1133641

SKT
Sickle tail protein homolog

1

0

High-throughput

0.518

High

2685

A0A0C3SFZ9
FCH and mu domain containing endocytic adaptor 1

1

2

High-throughput

0.515

High

1151258

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

399159

FGF1
Fibroblast growth factor 1

1

0

High-throughput

0.513

High

509137

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

905749

RS7
Small ribosomal subunit protein eS7

1

0

High-throughput

0.513

High

951780

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

1294225

SCLY
Selenocysteine lyase

1

0

High-throughput

0.513

High

1333521

NOL11
Nucleolar protein 11

1

0

High-throughput

0.513

High

1343599

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

613589

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

High-throughput

0.508

High

1298661

ZN558
Zinc finger protein 558

1

1

High-throughput

0.508

High

1343602

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

3

High-throughput

0.508

High

890853

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.501

High

538039

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.486

High

1302627

CK5P1
Mitochondrial tRNA methylthiotransferase CDK5RAP1

1

0

High-throughput

0.486

High

1343595

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.486

High

531515

K1C13
Keratin, type I cytoskeletal 13

1

6

High-throughput

0.481

High

838300

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

912195

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

5

High-throughput

0.481

High

1044713

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.481

High

1125959

ZMAT1
Zinc finger matrin-type protein 1

1

1

High-throughput

0.481

High

1235813

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

2

High-throughput

0.481

High

1343583

SHLB2
Endophilin-B2

1

2

High-throughput

0.481

High

1343597

SHLB1
Endophilin-B1

1

2

High-throughput

0.481

High

123025

MEN1
Menin

1

4

High-throughput

0.479

High

163328

XPO1
Exportin-1

1

3

High-throughput

0.479

High

256082

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

295290

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

298815

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

323182

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

442523

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

553804

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

721530

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

818497

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

841894

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

857016

THOP1
Thimet oligopeptidase

1

4

High-throughput

0.479

High

909177

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

1019137

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1171852

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1187800

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

1203145

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

1

Small-scale

0.479

High

1242462

PAPD5
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.479

High

1256416

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1269702

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1270945

KAT6A
Histone acetyltransferase KAT6A

1

5

High-throughput

0.479

High

1294034

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1343587

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

1343590

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1343592

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

718

A0A087WWI0
Leucine rich melanocyte differentiation associated

1

2

High-throughput

0.470

High

49580

A1A4E9
Keratin 13

1

6

High-throughput

0.470

High

921173

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.460

High

1030694

NMI
N-myc-interactor

1

0

High-throughput

0.460

High

1120332

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.460

High

1192387

YTHD3
YTH domain-containing family protein 3

1

0

High-throughput

0.460

High

719172

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

1184350

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1271670

DDX17
Probable ATP-dependent RNA helicase DDX17

1

0

Small-scale

0.458

High

103505

G4U4J3
PAP associated domain containing 5

1

3

High-throughput

0.445

High

1203581

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.445

High

1198248

DAAM2
Disheveled-associated activator of morphogenesis 2

1

1

High-throughput

0.439

High

1329447

LRMDA
Leucine-rich melanocyte differentiation-associated protein

1

1

High-throughput

0.439

High

1201697

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.437

High

110632

H3BNT4
M-phase phosphoprotein 6

1

6

High-throughput

0.407

High

1127592

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1166995

ATL4
ADAMTS-like protein 4

2

0

High-throughput

0.316

High

1170366

SHSA6
Protein shisa-6

2

0

High-throughput

0.316

High

1172894

NKAP1
Uncharacterized protein NKAPD1

2

0

High-throughput

0.316

High

1292767

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

254294

LRP4
Low-density lipoprotein receptor-related protein 4

1

0

High-throughput

0.279

Low

1221155

RM41
Large ribosomal subunit protein mL41

1

0

High-throughput

0.279

Low

1343601

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low

1256578

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.265

Low

1343604

LIPG
Endothelial lipase

1

0

High-throughput

0.265

Low

1223132

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024