HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: GIT1 (Q68FF6)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1)
Gene: GIT1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005096 - GTPase activator activity GO:0014069 - postsynaptic density GO:0045202 - synapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1340 Mm			1 770
+	Mm
		100045 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		AGAP1_MOUSE (2-245): 1.37e-55: 207: 32.53
+	Mm
		93411 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		E9Q3K3_MOUSE (2-245): 2.97e-52: 198: 32.53
+	Mm
		100015 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		ASAP2_MOUSE (2-456): 1.83e-51: 196: 16.22
+	Mm
		88329 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		D3YX85_MOUSE (2-456): 1.26e-51: 196: 16.22
+	Mm
		99881 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		F8VQE9_MOUSE (2-224): 1.77e-51: 195: 33.63
+	Mm
		99969 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		60399 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		POTEF_HUMAN (52-620): 2.03e-40: 162: 12.59
+	Hs
		1164363 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		POTEE_HUMAN (52-620): 2.12e-39: 159: 12.41
+	Mm
		100050 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		ANK2_MOUSE (89-573): 7.21e-30: 129: 11.89
+	Hs
		965139 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		ANK2_HUMAN (89-573): 7.15e-31: 133: 11.72
+	Hs
		1299752 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		TANC2_HUMAN (179-479): 2.76e-15: 82.6: 11.18
+	Hs
		556720 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		ANK1_HUMAN (225-526): 1.12e-09: 64.5: 10.39
+	Mm
		1012208 Q0VAV5_MOUSE (17-1338): 0: 890: 43.23		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Mm
		93233 E9PW37_MOUSE (17-1338): 0: 887: 43.30		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Mm
		1112542 DAB2P_MOUSE (97-1339): 0: 850: 47.79		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		1355995 NGAP_HUMAN (84-1338): 0: 800: 43.48		AGAP1_HUMAN (2-236): 4.18e-55: 205: 31.93
+	Hs
		596403 RASA1_HUMAN (184-715): 9.24e-130: 428: 23.82		ACAP2_HUMAN (2-306): 1.04e-53: 200: 18.11
+	Hs
		596415 RASA1_HUMAN (184-715): 9.24e-130: 428: 23.82		AN36B_HUMAN (114-766): 1.92e-50: 193: 12.13
+	Mm
		1112670 RASL1_MOUSE (162-688): 1.39e-121: 399: 19.26		AGAP2_MOUSE (2-224): 1.16e-46: 181: 29.15
+	Hs
		1021395 IQGA2_HUMAN (216-691): 7.87e-116: 400: 13.38		ANK3_HUMAN (174-528): 8.05e-33: 139: 10.36