HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: DGKZ (Q80UP3)
Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta)
Gene: DGKZ

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	27507650, 28706196, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction GO:0014069 - postsynaptic density GO:0046580 - negative regulation of Ras protein signal transduction GO:0098978 - glutamatergic synapse
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1340 Mm			1 929
+	Hs
		965139 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		ANK2_HUMAN (538-929): 2.28e-64: 239: 12.80
+	Mm
		100050 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		ANK2_MOUSE (537-878): 7.4e-41: 166: 10.80
+	Hs
		556720 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		ANK1_HUMAN (782-929): 3.64e-38: 157: 25.68
+	Hs
		1299772 SYGP1_HUMAN (1-1340): 0: 1065: 98.59		RAI14_HUMAN (663-895): 1.41e-20: 99.8: 17.43
+	Hs
		1021395 IQGA2_HUMAN (216-691): 7.87e-116: 400: 13.38		ANK3_HUMAN (796-929): 2.55e-40: 164: 27.61
+	Hs
		809460 IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97		RAI14_HUMAN (663-895): 1.41e-20: 99.8: 17.43