HitPredict

Interactor 1: VPS2B (Q0WTY4)
Vacuolar protein sorting-associated protein 2 homolog 2 (AtVPS2-2) (Charged multivesicular body protein 2 homolog 2) (ESCRT-III complex subunit VPS2 homolog 2)
Gene: VPS2.2

Interactor 2: VPS2B (Q0WTY4)
Vacuolar protein sorting-associated protein 2 homolog 2 (AtVPS2-2) (Charged multivesicular body protein 2 homolog 2) (ESCRT-III complex subunit VPS2 homolog 2)
Gene: VPS2.2

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.746

Property	Details
Experiments	22010978
Identification Methods	affinity chromatography technology, two hybrid, protein complementation assay, bimolecular fluorescence complementation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0000815 - ESCRT III complex GO:0005771 - multivesicular body GO:0015031 - protein transport GO:0032509 - endosome transport via multivesicular body sorting pathway GO:0045324 - late endosome to vacuole transport
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 222 At			1 222
+	At
		1013164 VPS2A_ARATH (2-222): 6.22e-58: 184: 40.99		VPS2B_ARATH (1-222): 2.69e-53: 172: 100.00
+	At
		1322583 VPS2A_ARATH (2-222): 6.22e-58: 184: 40.99		VP241_ARATH (1-220): 1.95e-45: 152: 28.13
+	Sc
		732840 DID4_YEAST (3-221): 2.54e-51: 167: 33.04		DID4_YEAST (3-221): 2.54e-51: 167: 33.04
+	At
		1013147 VPS2B_ARATH (1-222): 2.69e-53: 172: 100.00		CHM1A_ARATH (12-220): 1.09e-46: 154: 22.49
+	Dm
		1371191 Q9VN02_DROME (1-220): 1.53e-50: 165: 24.32		Q9VRJ5_DROME (2-206): 5.9e-47: 156: 31.71
+	Hs
		1377693 CHMP3_HUMAN (1-220): 1.47e-48: 160: 22.97		CHMP3_HUMAN (1-220): 1.47e-48: 160: 22.97
+	Hs
		208872 CHMP3_HUMAN (1-220): 1.47e-48: 160: 22.97		CHM2A_HUMAN (3-221): 3.17e-48: 159: 35.62
+	Hs
		208801 CHM2A_HUMAN (3-221): 3.17e-48: 159: 35.62		CHM2A_HUMAN (3-221): 3.17e-48: 159: 35.62
+	Dm
		1362009 Q9VN02_DROME (1-220): 1.53e-50: 165: 24.32		Q9VBI3_DROME (3-199): 1.6e-44: 151: 36.04
+	At
		1013166 VPS2B_ARATH (1-222): 2.69e-53: 172: 100.00		CHM1B_ARATH (12-220): 1.06e-41: 142: 22.49
+	Hs
		1357921 CHMP3_HUMAN (1-220): 1.47e-48: 160: 22.97		CHM2B_HUMAN (1-204): 9e-46: 152: 33.82
+	Sc
		732538 DID4_YEAST (3-221): 2.54e-51: 167: 33.04		VPS24_YEAST (7-221): 1.59e-41: 142: 17.59
+	Dm
		1362010 Q9VRJ5_DROME (2-206): 5.9e-47: 156: 31.71		Q9VBI3_DROME (3-199): 1.6e-44: 151: 36.04
+	Dm
		1279487 Q9VN02_DROME (1-220): 1.53e-50: 165: 24.32		Q95SH2_DROME (14-221): 6.7e-41: 140: 25.48
+	Dm
		1279488 Q9VRJ5_DROME (2-206): 5.9e-47: 156: 31.71		Q95SH2_DROME (14-221): 6.7e-41: 140: 25.48
+	Sc
		732857 DID4_YEAST (3-221): 2.54e-51: 167: 33.04		DID2_YEAST (14-220): 3.25e-33: 120: 17.39