HitPredict

Interactor 1: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Interactor 2: AAK1 (Q2M2I8)
AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1)
Gene: AAK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 949 Hs			1 961
+	Hs
		925884 AP2B1_HUMAN (1-949): 0: 944: 81.45		AAK1_HUMAN (1-961): 0: 720: 100.00
+	Hs
		321559 AP2A1_HUMAN (12-943): 0: 677: 18.58		AAK1_HUMAN (1-961): 0: 720: 100.00
+	Hs
		1014089 AP1B1_HUMAN (1-949): 0: 978: 100.00		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Hs
		926022 AP2B1_HUMAN (1-949): 0: 944: 81.45		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Hs
		302160 AP2A2_HUMAN (12-945): 0: 625: 18.33		AAK1_HUMAN (1-961): 0: 720: 100.00
+	Mm
		949409 AP2B1_MOUSE (1-949): 0: 944: 81.35		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Hs
		926058 AP2B1_HUMAN (1-949): 0: 944: 81.45		AKT3_HUMAN (8-386): 1.3e-117: 370: 17.81
+	Dm
		1096899 Q24253_DROME (1-949): 0: 851: 72.74		Q7KT38_DROME (1-634): 7.93e-120: 383: 36.12
+	Hs
		161644 AP2B1_HUMAN (1-949): 0: 944: 81.45		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33
+	Hs
		321653 AP2A1_HUMAN (12-943): 0: 677: 18.58		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Mm
		567496 AP2A1_MOUSE (12-943): 0: 673: 17.97		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Hs
		302214 AP2A2_HUMAN (12-945): 0: 625: 18.33		BMP2K_HUMAN (37-767): 7.31e-125: 409: 47.28
+	Mm
		567521 AP2A2_MOUSE (12-945): 0: 634: 17.94		TNIK_MOUSE (24-782): 6.51e-116: 388: 13.73
+	Dm
		954827 AP2A_DROME (12-943): 0: 608: 16.06		Q7KT38_DROME (1-634): 7.93e-120: 383: 36.12
+	Hs
		212600 AP1G1_HUMAN (12-822): 0: 556: 17.29		AKT2_HUMAN (11-386): 3.23e-117: 369: 17.69
+	Hs
		120000 AP3B1_HUMAN (6-620): 6.51e-156: 489: 27.73		MINK1_HUMAN (23-889): 2.9e-117: 391: 15.13
+	Dm
		1181922 Q7KVR8_DROME (12-822): 3.54e-159: 495: 14.02		Q7KT38_DROME (1-634): 7.93e-120: 383: 36.12
+	Hs
		161603 AP2A1_HUMAN (12-943): 0: 677: 18.58		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33
+	Hs
		161600 AP2A2_HUMAN (12-945): 0: 625: 18.33		GAK_HUMAN (18-309): 7.18e-44: 175: 38.33