HitPredict

Interactor 1: AP1B1 (Q10567)
AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)
Gene: AP1B1

Interactor 2: Q86V28 (Q86V28)
AP-1 complex subunit gamma
Gene: Q86V28

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	unassigned1304
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Adaptin_N~Adaptin_N, Alpha_adaptinC2~Alpha_adaptinC2, Alpha_adaptinC2~B2-adapt-app_C
Common GO terms	GO:0006886 - intracellular protein transport GO:0030121 - AP-1 adaptor complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 949 Hs			1 640
+	Hs
		212624 AP1B1_HUMAN (1-949): 0: 978: 100.00		AP1G1_HUMAN (1-640): 0: 579: 52.27
+	Hs
		276366 AP1B1_HUMAN (1-949): 0: 978: 100.00		AP1G2_HUMAN (1-640): 0: 550: 93.02
+	Hs
		212616 AP2B1_HUMAN (1-949): 0: 944: 81.45		AP1G1_HUMAN (1-640): 0: 579: 52.27
+	Hs
		276363 AP2B1_HUMAN (1-949): 0: 944: 81.45		AP1G2_HUMAN (1-640): 0: 550: 93.02
+	Hs
		302144 AP1B1_HUMAN (1-949): 0: 978: 100.00		AP2A2_HUMAN (1-631): 4.32e-134: 418: 20.93
+	Hs
		321535 AP1B1_HUMAN (1-949): 0: 978: 100.00		AP2A1_HUMAN (1-631): 5.15e-130: 408: 21.61
+	Hs
		925858 AP1B1_HUMAN (1-949): 0: 978: 100.00		AP2B1_HUMAN (8-592): 5.94e-125: 393: 13.60
+	Hs
		302132 AP2B1_HUMAN (1-949): 0: 944: 81.45		AP2A2_HUMAN (1-631): 4.32e-134: 418: 20.93
+	Mm
		567513 AP2B1_MOUSE (1-949): 0: 944: 81.35		AP2A1_MOUSE (1-631): 1.59e-131: 412: 21.88
+	Hs
		321523 AP2B1_HUMAN (1-949): 0: 944: 81.45		AP2A1_HUMAN (1-631): 5.15e-130: 408: 21.61
+	Dm
		954826 Q24253_DROME (1-949): 0: 851: 72.74		AP2A_DROME (1-634): 8.28e-125: 393: 21.07
+	At
		286690 APBLC_ARATH (3-948): 0: 788: 57.01		AP2A1_ARATH (1-578): 1.2e-125: 397: 20.44
+	At
		1228260 APBLB_ARATH (3-948): 0: 774: 56.69		AP2A1_ARATH (1-578): 1.2e-125: 397: 20.44
+	Hs
		926029 AP2B1_HUMAN (1-949): 0: 944: 81.45		GGA3_HUMAN (448-639): 1.81e-42: 165: 27.94
+	Hs
		926049 AP2B1_HUMAN (1-949): 0: 944: 81.45		GGA2_HUMAN (439-635): 1.47e-39: 155: 25.37
+	Hs
		302075 AP2A1_HUMAN (12-943): 0: 677: 18.58		AP2A2_HUMAN (1-631): 4.32e-134: 418: 20.93